Deerfield, Illinois Clinical Trials

A listing of Deerfield, Illinois clinical trials actively recruiting patient volunteers.

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Found 86 clinical trials
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A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

nivolumab
experimental drug
squamous non-small cell lung cancer
non-squamous non-small cell lung cancer
advanced lung cancer
Illinois Cancer Specialists - Niles
 (9.9 away) Contact site
  • 213 views
  • 28 Jul, 2021
  • +188 other locations
featured
Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation (KRYSTAL-7)

This Phase 2 study evaluates the clinical activity and safety of MRTX849 in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS.

KRAS
pembrolizumab
USOR - Illinois Cancer Specialists - Niles
 (9.9 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +40 other locations
Study of Evobrutinib in Participants With RMS (evolutionRMS 1)

The study is to evaluate the efficacy and safety of evobrutinib administered orally twice daily versus Teriflunomide (Aubagio), administered orally once daily in participants with Relapsing Multiple Sclerosis (RMS).

evobrutinib
teriflunomide
aubagio
Research Site 649
 (3.3 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +270 other locations
Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)

The purpose of this study is to evaluate the efficacy and safety of pemigatinib in participants with previously treated locally advanced/metastatic or surgically unresectable solid tumor malignancies harboring activating FGFR mutations or translocations.

Illinois Cancer Specialists
 (9.8 away) Contact site
  • 50 views
  • 01 Aug, 2021
  • +122 other locations
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168)

Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary Objective: To assess efficacy of SAR442168 compared to teriflunomide (Aubagio) on disability progression, MRI lesions, cognitive performance …

brain lesion
teriflunomide
aubagio
contraceptive use
hmr1726
Investigational Site Number 8400011
 (3.3 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +120 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

hydrochlorothiazide
corticosteroids
liver metastasis
major surgery
bevacizumab
NorthShore University HealthSystem-Highland Park Hospital
 (2.8 away) Contact site
  • 65 views
  • 27 Jul, 2021
  • +978 other locations
Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma

Unity NHL - A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + Umbralisib with or without Bendamustine and Umbralisib alone in Patients with Previously Treated Non-Hodgkin's Lymphoma

diffuse large b-cell lymphoma
lymphoma
ibrutinib
marginal zone lymphoma
b-cell lymphoma
TG Therapeutics Investigational Trial Site
 (9.9 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +203 other locations
Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits …

diuretic therapy
stroke
heart disease
nt-probnp
ejection fraction
Advocate Condell Medical Center
 (8.9 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +778 other locations
Randomized Study in Children and Adolescents With Migraine: Acute Treatment

The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.

acute treatment
erenumab
migraine in children
Capstone Clinical Research
 (8.9 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +108 other locations
Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone. Patients will be randomly assigned to …

lenalidomide
brentuximab
rituximab
b-cell lymphoma
measurable disease
Illinois Cancer Specialists / Advocate Lutheran General Hospital
 (9.8 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +74 other locations