Centralia, Illinois Clinical Trials

A listing of Centralia, Illinois clinical trials actively recruiting patient volunteers.

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Found 45 clinical trials
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

interleukin 2
pembrolizumab
tremelimumab
karnofsky performance status
measurable disease
Centralia Oncology Clinic
 (0.4 away) Contact site
  • 157 views
  • 19 Sep, 2021
  • +688 other locations
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage HPV-Positive Non-Smoking Associated Oropharyngeal Cancer

This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its growth and may not have spread to other parts of the body (early-stage), and is not associated …

pet/ct scan
measurable disease
carcinoma
cigarette smoking
hepatitis b virus surface antigen
Centralia Oncology Clinic
 (0.4 away) Contact site
  • 28 views
  • 19 Sep, 2021
  • +236 other locations
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the …

combination chemotherapy
topical steroids
vinblastine
measurable disease
classical hodgkin lymphoma
Centralia Oncology Clinic
 (0.4 away) Contact site
  • 72 views
  • 19 Sep, 2021
  • +511 other locations
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

This phase III trial studies whether pembrolizumab alone as a first-line treatment, followed by pemetrexed and carboplatin with or without pembrolizumab after disease progression is superior to induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. …

cancer treatment
thyroxine
squamous non-small cell lung carcinoma
pembrolizumab
measurable disease
Cancer Care Center of O'Fallon
 (41.9 away) Contact site
  • 213 views
  • 19 Sep, 2021
  • +832 other locations
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

This phase II/III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

Centralia Oncology Clinic
 (0.4 away) Contact site
  • 135 views
  • 16 Sep, 2021
  • +540 other locations
A Study Evaluating Whether Pembrolizumab Alone or in Combination With CMP-001 Improves Efficacy in Patients With Operable Melanoma

This phase II trial studies the effect of pembrolizumab alone or in combination with CMP-001 in treating patients with melanoma that can be treated by surgery (operable). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of …

Centralia Oncology Clinic
 (0.4 away) Contact site
  • 0 views
  • 12 Sep, 2021
  • +114 other locations
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

This phase III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells …

Centralia Oncology Clinic
 (0.4 away) Contact site
  • 0 views
  • 18 Sep, 2021
  • +71 other locations
Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

This trial studies the side effects of radiation therapy followed by atezolizumab in treating patients with stage II or III non-small cell lung cancer. Hyperfractionated radiation therapy delivers smaller doses of radiation therapy over time and may kill more tumor cells and have fewer side effects. Immunotherapy with monoclonal antibodies, …

monoclonal antibody therapy
hysterectomy
skin cancer
neutrophil count
tumor cells
Cancer Care Center of O'Fallon
 (41.9 away) Contact site
  • 0 views
  • 12 Sep, 2021
  • +61 other locations
EA2176: Phase 3 Clinical Trial of Carboplatin and Pacliitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

This phase 3 trial compares the addition of nivolumab to chemotherapy (carboplatin and paclitaxel) versus usual treatment (chemotherapy alone) for the treatment of anal cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the …

Centralia Oncology Clinic
 (0.4 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +440 other locations
A Randomized Study of Olaparib or Placebo in Patients With Surgically Removed Pancreatic Cancer Who Have a BRCA1 BRCA2 or PALB2 Mutation The APOLLO Trial

This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps …

palb2
BRCA1
cancer chemotherapy
carcinoma
tumor cells
Centralia Oncology Clinic
 (0.4 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +217 other locations