Waterloo, Iowa Clinical Trials

A listing of Waterloo, Iowa clinical trials actively recruiting patient volunteers.

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Found 14 clinical trials
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

measurable disease
folfiri
irinotecan
major surgery
vitamin d
MercyOne Waterloo Medical Center
 (1.5 away) Contact site
  • 65 views
  • 27 Jan, 2021
  • +905 other locations
S0820 Adenoma and Second Primary Prevention Trial

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon or rectal cancer.

aspirin
anticoagulants
adenoma
rectal carcinoma
unstable angina
MercyOne Waterloo Medical Center
 (1.5 away) Contact site
  • 2518 views
  • 26 Jan, 2021
  • +1023 other locations
Ibrutinib and Obinutuzumab With or Without Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia

This phase III trial studies how well ibrutinib and obinutuzumab with or without venetoclax work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Obinutuzumab is a monoclonal antibody that may interfere with the …

chemotherapy drugs
monoclonal protein
fatigue
cyclin d1
lymphocytosis
MercyOne Waterloo Medical Center
 (1.5 away) Contact site
  • 624 views
  • 27 Jan, 2021
  • +719 other locations
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

This phase III trial studies whether pembrolizumab alone as a first-line treatment, followed by pemetrexed and carboplatin with or without pembrolizumab after disease progression is superior to induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. …

hepatitis b
hepatitis c virus
anticonvulsants
ROS1
hysterectomy
MercyOne Waterloo Medical Center
 (2.7 away) Contact site
  • 206 views
  • 27 Jan, 2021
  • +786 other locations
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in the treatment of adults who have high-risk early-stage estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer. The primary …

paclitaxel
estrogen receptor
growth factor
estrogen
endocrine therapy
MercyOne Waterloo Cancer Center ( Site 0016)
 (1.5 away) Contact site
  • 188 views
  • 27 Jan, 2021
  • +275 other locations
Dissemination of the Cardiovascular Risk Service

The objective of this study is to evaluate the implementation of of a remote, pharmacist-led cardiovascular risk service (CVRS) in 12 large, organizationally and culturally diverse hospitals and health-systems, many with high proportions of minority and underserved patients.

diabetes
hypertension
systolic blood pressure
Northeast Iowa Family Practice Center
 (1.5 away) Contact site
  • 67 views
  • 25 Jan, 2021
  • +13 other locations
A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of anamorelin HCl. Approximately 316 patients with advanced NSCLC with cachexia will be randomized 1:1 to anamorelin HCl 100 mg or placebo, taken orally once daily (QD) for a total of 24 weeks. Patients will be instructed to …

body mass index
cancer chemotherapy
liver metastases
targeted therapy
anamorelin hydrochloride
MercyOne Waterloo Cancer Center
 (1.5 away) Contact site
  • 197 views
  • 26 Jan, 2021
  • +72 other locations
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation …

diabetes
myocardial infarction
acute coronary syndrome
infarct
arterial disease
8400904 - Northeast Iowa Medical Education Foundation
 (1.5 away) Contact site
  • 1118 views
  • 27 Jan, 2021
  • +3410 other locations
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual …

MercyOne Waterloo Medical Center
 (2.7 away) Contact site
  • 139 views
  • 26 Jan, 2021
  • +468 other locations
Breast Cancer WEight Loss Study (BWEL Study)

This randomized phase III trial studies whether weight loss in overweight and obese women may prevent breast cancer from coming back (recurrence). Previous studies have found that women who are overweight or obese when their breast cancer is found (diagnosed) have a greater risk of their breast cancer recurring, as …

carcinoma
breast carcinoma
sentinel lymph node biopsy
breast-conserving surgery
progesterone receptor
MercyOne Waterloo Medical Center
 (1.5 away) Contact site
  • 4083 views
  • 27 Jan, 2021
  • +1593 other locations