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Iowa City, Iowa Clinical Trials

A listing of Iowa City, Iowa clinical trials actively recruiting patient volunteers.

RESULTS

Found (10) clinical trials

A Study of Deflazacort (Emflaza ) in Participants With Limb-Girdle Muscular Dystrophy 2I (LGMD2I)

This study is designed to evaluate the safety and efficacy of deflazacort in participants with LGMD2I. The study will include a 26-week double-blind, randomized, placebo-controlled period followed by a 26-week open-label extension period during which all participants will receive deflazacort.

Phase

3.03 miles

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Sleep for Stroke Management and Recovery Trial

Sleep SMART has a prospective, randomized, open-label, blinded-endpoint (PROBE) design. It is a multi-site, parallel-group superiority trial that compares 6 months of OSA treatment to usual care. The study includes two trials: a prevention study with an embedded recovery trial. 3062 subjects will be randomized over 5 years at 110 ...

Phase N/A

3.03 miles

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High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas

Phase Ib: The phase Ib portion of this study is to ensure the safety and tolerability of high dose ascorbate in combination with external beam radiation therapy (EBRT) as assessed by incidence of dose-limiting toxicities (DLT). EBRT will be given at the standard dose for resectable soft tissue sarcomas according ...

Phase

3.03 miles

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Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)

The genetic heterogeneity has been a barrier to broad natural history efforts, with prior investigations often limited to single gene mutations. Much attention is paid to the variability within individual mutations (e.g. distal presentations), as opposed to defining the best strategy for measuring change in overall LGMD disease burden. This ...

Phase N/A

3.03 miles

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Extension Study to Study PQ-110-001 (NCT03140969)

Subjects completing participation in study PQ-110-001 (EudraCT 2017-000813-22 / NCT03140969) will be given the opportunity to enroll into the extension study for continued dosing if available data support current and/or future benefits for the subject. Subjects will be given the opportunity to enroll into this extension study for continued dosing ...

Phase

3.03 miles

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A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE)

The reason for this long term study is to see how safe and effective the study drug known as baricitinib is in participants with systemic lupus erythematosus (SLE) who have completed the final treatment visit of study I4V-MC-JAHZ (NCT03616912) or study I4V-MC-JAIA (NCT03616964).

Phase

3.03 miles

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A Patient Registry Study for Patients Treated With Voretigene Neparvovec

Voretigene neparvovec-rzyl is a gene therapy intended for use in individuals with confirmed biallelic RPE65 mutation-associated retinal dystrophy and viable retinal cells. Mutations in the RPE65 gene are associated with several clinical manifestations including nyctalopia, decreased visual field and decreased visual acuity. Voretigene neparvovec-rzyl uses a non-pathogenic recombinant adeno-associated virus ...

Phase N/A

3.03 miles

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Safety Tolerability and Effect on Liver Histologic Parameters of ARO-AAT

In Part A, participants will be enrolled to receive multiple doses of ARO-AAT or placebo at varying dose levels. Once Part A is complete, a single dose level for Part B will be selected based on safety and pharmacodynamic parameters from Part A. Patients enrolled into Part A will roll ...

Phase

3.03 miles

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ACURATE IDE: Safety and Efficacy Study of Acurate Valve for Transcatheter Aortic Valve Replacement

Subjects will be enrolled at up to 50 centers in the United States and Canada. There will be up to 600 subjects in ACURATE IDE. The ACURATE IDE study cohorts include the following. Randomized Cohort: A prospective, multicenter, 1:1 randomized controlled trial (RCT; ACURATE versus a commercially available balloon-expandable SAPIEN ...

Phase N/A

3.03 miles

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Pilot Study of Annie Text Messaging for Depression Treatment Adherence

Background: There are several known challenges to starting a medication for depression, such as side effects and needing four to six weeks before the effects of the medication may be noticed. This pilot randomized controlled trial will compare usual care to an intervention which aims to improve antidepressant adherence and ...

Phase N/A

5.75 miles

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