Kuakini, Hawaii Clinical Trials

A listing of Kuakini, Hawaii clinical trials actively recruiting patient volunteers.

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Found 121 clinical trials
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

This Phase III, randomized, double-blind, placebo-controlled, multicenter study will evaluate the efficacy and safety of giredestrant combined with palbociclib compared with letrozole combined with palbociclib in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative locally advanced (recurrent or progressed) or metastatic breast cancer.

Kaiser Permanente - Moanalua Medical Center
 (2.9 away) Contact site
  • 0 views
  • 02 May, 2022
  • +279 other locations
A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer (EMBER-3)

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy, and how well imlunestrant with abemaciclib work compared to imlunestrant in participants with breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have breast …

HER2
epidermal growth factor receptor
hormone therapy
erbb2
exemestane
Kaiser Permanente Moanalua Medical Center
 (2.1 away) Contact site
  • 7 views
  • 02 May, 2022
  • +157 other locations
Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

This phase III trial compares an additional support program (text message reminders and/or telephone-based counseling) with usual care in making sure breast cancer patients take their endocrine therapy medication as prescribed (medication adherence). Medication adherence is how well patients take the medication as prescribed by their doctors, and good medical …

Queen's Cancer Cenrer - POB I
 (0.5 away) Contact site
  • 264 views
  • 06 May, 2022
  • +450 other locations
S0820, Adenoma and Second Primary Prevention Trial (PACES)

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon or rectal cancer.

aspirin
unstable angina
rectal carcinoma
anticoagulants
adenoma
Queen's Medical Center
 (0.5 away) Contact site
  • 2944 views
  • 10 May, 2022
  • +407 other locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

antibiotics
monoclonal antibodies
platelet count
stage iii colon cancer
monoclonal antibody therapy
Island Urology
 (0.5 away) Contact site
  • 1144 views
  • 10 May, 2022
  • +553 other locations
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

erlotinib
squamous cell carcinoma
crizotinib
nivolumab
pembrolizumab
Island Urology
 (0.5 away) Contact site
  • 1148 views
  • 10 May, 2022
  • +1043 other locations
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

This phase III trial studies whether pembrolizumab alone as a first-line treatment, followed by pemetrexed and carboplatin with or without pembrolizumab after disease progression is superior to induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. …

monoclonal antibodies
oophorectomy
squamous non-small cell lung carcinoma
tyrosine
adjuvant therapy
Island Urology
 (0.5 away) Contact site
  • 322 views
  • 10 May, 2022
  • +779 other locations
Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy (IMAGINE)

This phase III trial compares survival in urothelial cancer patients who stop immune checkpoint inhibitor treatment after being treated for about a year to those patients who continue treatment with immune checkpoint inhibitors. Immunotherapy with monoclonal antibodies, such as avelumab, durvalumab, pembrolizumab, atezolizumab, and nivolumab, may help the body's immune …

Kaiser Permanente Moanalua Medical Center
 (2.1 away) Contact site
  • 4 views
  • 03 May, 2022
  • +340 other locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

adrenaline
crizotinib
mammogram
immunohistochemistry
oophorectomy
Island Urology
 (0.5 away) Contact site
  • 6567 views
  • 09 May, 2022
  • +924 other locations
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who roll-over into this extension study. This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. …

metastasis
pembrolizumab
mk-3475
major surgery
Kaiser Permanente Moanalua Medical Center ( Site 0063)
 (0.9 away) Contact site
  • 755 views
  • 10 May, 2022
  • +291 other locations