Kuakini, Hawaii Clinical Trials

A listing of Kuakini, Hawaii clinical trials actively recruiting patient volunteers.

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Found 121 clinical trials
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery (ASPIRE)

Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes …

fibrillation
electrocardiogram
apixaban
anticoagulation therapy
brain ct
The Queen's Medical Center
 (0.5 away) Contact site
  • 84 views
  • 21 Apr, 2022
  • +117 other locations
To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age.

Substudy A: The study will evaluate the safety, tolerability, and efficacy of a booster dose of BNT162b2 when administered to participants having previously received 2 doses of BNT162b2 at least 6 months prior to randomization. The study is designed to describe vaccine efficacy of a booster dose of BNT162b2 over …

Accepts healthy volunteers
East-West Medical Research Institute
 (1.9 away) Contact site
  • 50 views
  • 20 Apr, 2022
  • +48 other locations
AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke (ARCADIA)

Objectives Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

brain imaging
recurrent strokes
aspirin
hemorrhagic stroke
infarct
The Queen's Medical Center
 (0.9 away) Contact site
  • 416 views
  • 26 Apr, 2022
  • +135 other locations
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM)

The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to …

glibenclamide
thrombectomy
MRI
glyburide
stroke
Research Site
 (0.5 away) Contact site
  • 324 views
  • 03 May, 2022
  • +113 other locations
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT)

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

body mass index
hemoglobin a1c
cardiovascular disease
East-West Medical Research Institute
 (2.0 away) Contact site
  • 919 views
  • 05 May, 2022
  • +590 other locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

teratoma
neuroendocrine carcinoma
trophoblastic disease
thyroiditis
remission
Island Urology
 (0.5 away) Contact site
  • 6607 views
  • 11 May, 2022
  • +766 other locations
Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery

This phase II/III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works in predicting treatment for patients with stage IIA colon cancer after surgery. ctDNA are circulating tumor cells that are shed by tumors into the blood. Finding ctDNA in the blood means that there …

oxaliplatin
tumor cells
capecitabine
colon cancer
cancer
Hawaii Cancer Care Inc - Waterfront Plaza
 (0.9 away) Contact site
  • 0 views
  • 12 May, 2022
  • +600 other locations
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may …

advanced melanoma
mdx-ctla-4
interferon
tumor cells
metastasis
Hawaii Cancer Care Inc - Waterfront Plaza
 (0.9 away) Contact site
  • 162 views
  • 12 May, 2022
  • +425 other locations
Trial of Parkinson's And Zoledronic Acid (TOPAZ)

This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will …

screening procedures
atrophy
parkinson's disease
supranuclear palsy
dementia
Queens Medical Center
 (0.5 away) Contact site
  • 256 views
  • 12 May, 2022
  • +52 other locations
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

Hawaii Cancer Care Inc - Waterfront Plaza
 (0.9 away) Contact site
  • 363 views
  • 12 May, 2022
  • +464 other locations