Kuakini, Hawaii Clinical Trials

A listing of Kuakini, Hawaii clinical trials actively recruiting patient volunteers.

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Found 121 clinical trials
A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

The purpose of the study is to assess the success of a single administration of Staccato alprazolam compared with placebo both in rapidly terminating a seizure episode within 90 seconds and with no recurrence of seizure(s) up to 2 hours after investigational medicinal product (IMP) administration.

Ep0162 50323
 (1.8 away) Contact site
  • 15 May, 2022
  • +19 other locations
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Patients With Traumatic Brain Injury

This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury (TBI).

Hawaii Pacific Neuroscience
 (1.8 away) Contact site
  • 11 May, 2022
  • +26 other locations
Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema

To evaluate the safety and efficacy of LKA651 in patients with macular edema from diabetic macular edema (DME),

type 2 diabetes mellitus
spectral domain optical coherence tomography
Novartis Investigative Site
 (6.7 away) Contact site
  • 16 May, 2022
  • +4 other locations
Tenecteplase in Stroke Patients Between 4.5 and 24 Hours (TIMELESS)

This study will evaluate the efficacy and safety of tenecteplase compared with placebo in participants with acute ischemic stroke (AIS). All participants will receive standard-of-care therapy according to AmericanHeart Association/American Stroke Association clinical guidelines (2018). To determine eligibility for randomization, all participants will undergo multimodal CT or MRI at baseline. …

The Queen's Medical Center
 (0.5 away) Contact site
  • 01 May, 2022
  • +51 other locations
The Healthy Diet and Lifestyle Study II ((HDLS2))

Intermittent energy restriction (IER) may have important advantages over daily energy restriction (DER) in producing sustained weight loss and reducing cancer risk. IER is already being promoted with limited evidence, thus, additional evidence is urgently needed from rigorously conducted clinical trials. IER has been proposed to invoke a greater metabolic …

Accepts healthy volunteers
University of Hawaii Cancer Center
 (0.5 away) Contact site
  • 02 May, 2022
  • 1 location
A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)

This is a 12-week, double-blind, placebo-controlled, randomized, parallel-group, multicenter study of the safety and efficacy of JZP385 in the treatment of adult participants with moderate to severe ET.

Hawaii Pacific Neuroscience
 (0.5 away) Contact site
  • 10 May, 2022
  • +14 other locations
Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia

This randomized phase II trial studies how well ruxolitinib phosphate, and bosutnib, dasatinib, imatinib or nilotinib, work in treating patients with chronic myeloid leukemia. Chronic myeloid leukemia cells produce a protein called BCR-ABL. The BCR-ABL protein helps chronic myeloid leukemia cells to grow and divide. Tyrosine kinase inhibitors, such as …

Queen's Medical Center
 (0.5 away) Contact site
  • 17 May, 2022
  • +391 other locations
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR)

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE: Due to character limits, the arms section does …

neutrophil count
advanced cancer
multiple myeloma
hodgkin's disease
The Queen's Medical Center (The University of Texas MD Anderson Cancer Center)
 (0.5 away) Contact site
  • 22 Apr, 2022
  • +105 other locations
Efficacy and Safety of CUSA-081 in the Restoration of Central Venous Access Device (CVAD) Functionality (READY 1)

Study to evaluate the efficacy and safety of CUSA-081 in the restoration of central venous access device (CVAD) functionality in participants 18 years and older.

tissue plasminogen activator
Chiesi Investigational Site
 (2.0 away) Contact site
  • 24 Apr, 2022
  • +62 other locations
A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will …

Novo Nordisk Investigational Site
 (1.9 away) Contact site
  • 21 Apr, 2022
  • +144 other locations