Honolulu, Hawaii Clinical Trials

A listing of Honolulu, Hawaii clinical trials actively recruiting patient volunteers.

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Found 84 clinical trials
Featured trial
A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

cancer chemotherapy
cancer
nivolumab
lung carcinoma
non-squamous non-small cell lung cancer
Straub Medical Center
 (0.8 away) Contact site
  • 417 views
  • 14 Jan, 2022
  • +215 other locations
None
An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Dimethyl Fumarate or Fingolimod to Ofatumumab

The open label study to evaluate effectiveness of treatment with ofatumumab in patients transitioning from commonly used oral MS therapies - fingolimod or dimethyl fumarate, due to breakthrough disease.

fingolimod
ofatumumab
dimethyl fumarate
Novartis Investigative Site
 (2.8 away) Contact site
  • 0 views
  • 02 Jan, 2022
  • +129 other locations
None
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

The purpose of this study is to assess the efficacy of lazertinib, amivantamab, carboplatin, and pemetrexed (LACP) compared with carboplatin and pemetrexed (CP), in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure.

carboplatin
epidermal growth factor
kinase inhibitor
non-squamous non-small cell lung cancer
pemetrexed
Pacific Health Research and Education Institute
 (4.0 away) Contact site
  • 7 views
  • 09 Jan, 2022
  • +278 other locations
None
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis

To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis

Novartis Investigative Site
 (1.1 away) Contact site
  • 0 views
  • 02 Jan, 2022
  • +1 other locations
None
A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will …

Novo Nordisk Investigational Site
 (1.1 away) Contact site
  • 20 views
  • 02 Jan, 2022
  • +164 other locations
None
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

The purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a Novartis ofatumumab clinical MS study. Vaccination sub-study The purpose of this research sub-study is to find out the effects of ofatumumab on the development of antibody …

pneumococcal conjugate vaccine
ofatumumab
tetanus
Novartis Investigative Site
 (1.6 away) Contact site
  • 403 views
  • 11 Jan, 2022
  • +141 other locations
None
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge

Hawaii Pacific Health
 (0.8 away) Contact site
  • 34 views
  • 16 Jan, 2022
  • +114 other locations
None
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Patients With Traumatic Brain Injury

This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury (TBI).

Hawaii Pacific Neuroscience
 (2.8 away) Contact site
  • 3141 views
  • 02 Jan, 2022
  • +40 other locations
None
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

liver metastasis
adjuvant therapy
hydrochlorothiazide
major surgery
open biopsy
Hawaii Cancer Care Inc-POB II
 (0.8 away) Contact site
  • 124 views
  • 19 Jan, 2022
  • +962 other locations
None
Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage …

cancer chemotherapy
c-MET
cancer treatment
lung carcinoma
stage iv non-small cell lung cancer
Straub Clinic and Hospital /ID# 217905
 (0.8 away) Contact site
  • 132 views
  • 08 Jan, 2022
  • +374 other locations