Littleton, Colorado Clinical Trials

A listing of Littleton, Colorado clinical trials actively recruiting patient volunteers.

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Found 408 clinical trials
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab. (MANDARA)

This is a randomized, double blind, active-controlled, parallel group, multicenter 52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus mepolizumab 300 mg administered by subcutaneous (SC) injection in patients with relapsing or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive therapy. All …

anca
asthma
steroid therapy
immunosuppression
remission
Research Site
 (8.9 away) Contact site
  • 65 views
  • 28 Jul, 2022
  • +69 other locations
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW)

The main purpose of this study is to compare the clinical benefit, as measured by Progression-Free Survival (PFS), Objective Response Rate (ORR), and Overall Survival (OS), achieved by nivolumab in combination with ipilimumab or by nivolumab monotherapy in participants with Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) metastatic …

fluorouracil
bevacizumab
nivolumab
cetuximab
irinotecan
Rocky Mountain Cancer Centers
 (8.6 away) Contact site
  • 221 views
  • 28 Jul, 2022
  • +82 other locations
Safety Study of Etripamil Nasal Spray for Patients With Paroxysmal Supraventricular Tachycardia. NODE-303

NODE-303 is a multi-center, open label (OL) study to evaluate the safety of etripamil NS in patients with Paroxysmal Supraventricular Tachycardia (PSVT). Patients will be provided with an ambulatory Cardiac Monitoring System (CMS) to help document PSVT episodes. The CMS will be self-applied by the patient, when PSVT symptoms begin. …

101
 (1.8 away) Contact site
  • 116 views
  • 29 Jul, 2022
  • +80 other locations
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy (IMvigor011)

This is a global Phase III, randomized, placebo-controlled, double-blind study designed to evaluate the efficacy and safety of adjuvant treatment with atezolizumab compared with placebo in participants with MIBC who are ctDNA positive and are at high risk for recurrence following cystectomy.

Rocky Mountain Cancer Center - Denver
 (1.8 away) Contact site
  • 0 views
  • 09 Aug, 2022
  • +173 other locations
Flexible-Dose Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TemPo-3)

The purpose of this study is to assess the effect of tavapadon on the change from baseline in total daily hours of "on" time without troublesome dyskinesia in L-Dopa-treated participants with Parkinson's Disease (PD) who are experiencing motor fluctuations.

levodopa
mao-b inhibitor
carbidopa
dyskinesia
dopa
Denver Neurological Research
 (5.0 away) Contact site
  • 48 views
  • 04 Aug, 2022
  • +46 other locations
Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis

This will be prospective study of patients with knee effusion associated with degenerative osteoarthritis or symptomatic primary total knee arthroplasty that undergo therapeutic joint arthrocentesis. The diagnosis of knee osteoarthritis will be based on knee radiographs (including AP, Rosenburg view, lateral and Merchant views) read and interpreted by one of …

Accepts healthy volunteers
Colorado Joint Replacement
 (5.3 away) Contact site
  • 7 views
  • 14 Apr, 2022
  • +1 other locations
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors

To determine the safety profile, maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and recommended Phase 2 dose (RP2D) of FF-10850 (topotecan liposome injection) in patients with advanced solid tumors.

Sarah Cannon Research Institute at HealthONE
 (8.6 away) Contact site
  • 18 views
  • 29 Apr, 2022
  • +1 other locations
A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors

To determine the safety profile, maximum tolerated dose (MTD), dose-limiting toxicities (DLT) and recommended Phase 2 dose (RP2D) in patients who receive FF-10832 (Gemcitabine Liposome Injection) for treatment of advanced solid tumors.

Sarah Cannon Research Institute
 (8.6 away) Contact site
  • 50 views
  • 02 May, 2022
  • +3 other locations
A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

This is a Phase Ib/II study to evaluate the safety and efficacy of autologous T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 in adult patients with relapsed or refractory B cell acute lymphoblastic leukemia (ALL).

Colorado Blood Cancer Institute (CBCI)
 (8.6 away) Contact site
  • 0 views
  • 07 Jun, 2022
  • +31 other locations
A Study of TAK-676 as Single Agent and TAK-676 in Combination With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors

The main aim of this study is to check if people with advanced solid tumors have side effects from TAK-676, and to check how much TAK-676 they can receive without getting significant side effects from it when given alone and in combination with pembrolizumab. The study will be conducted in …

Sarah Cannon Research Institute- HealthOne, Denver
 (8.6 away) Contact site
  • 7 views
  • 30 May, 2022
  • +8 other locations