Littleton, Colorado Clinical Trials

A listing of Littleton, Colorado clinical trials actively recruiting patient volunteers.

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Found 98 clinical trials
PRV-015 in Gluten-free Diet Non-responsive Celiac Disease (PROACTIVE)

This study will evaluate the efficacy and safety of PRV-015 in adult patients with non-responsive celiac disease (NRCD) who are on a gluten-free diet (GFD).

gluten
abdominal pain
monoclonal antibodies
diarrhea
bloating
Clinical Site
 (7.2 away) Contact site
  • 352 views
  • 10 Aug, 2022
  • +38 other locations
Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-OLE)

This study will assess the safety and efficacy of ARQ-151 cream applied once a day for 52 weeks by subjects with atopic dermatitis (eczema).

Arcutis Clinical Site 123
 (8.7 away) Contact site
  • 0 views
  • 11 Aug, 2022
  • +90 other locations
Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients (APPLAUSE-IgAN)

The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of LNP023 at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.

adrenaline
treatment regimen
hbeag
fibrosis
proteinuria
Novartis Investigative Site
 (9.8 away) Contact site
  • 11 views
  • 11 Aug, 2022
  • +158 other locations
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

Rocky Mountain Cancer Centers-Littleton
 (1.2 away) Contact site
  • 428 views
  • 11 Aug, 2022
  • +460 other locations
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

This phase III trial studies whether pembrolizumab alone as a first-line treatment, followed by pemetrexed and carboplatin with or without pembrolizumab after disease progression is superior to induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. …

squamous non-small cell lung carcinoma
carboplatin
cardiac disease
ROS1
hepatitis b
Rocky Mountain Cancer Centers-Littleton
 (1.8 away) Contact site
  • 322 views
  • 09 Aug, 2022
  • +770 other locations
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)

This study is designed to assess the antitumor efficacy and safety of pembrolizumab in combination with BCG, compared to BCG monotherapy, in participants with HR NMIBC that is either persistent or recurrent following adequate BCG induction (Cohort A), or that is naïve to BCG treatment (Cohort B). The primary hypothesis …

Colorado Clinical Research ( Site 1100)
 (9.1 away) Contact site
  • 116 views
  • 10 Aug, 2022
  • +138 other locations
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA) (DEBRA)

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.

Littleton Adventist Hospital
 (3.9 away) Contact site
  • 0 views
  • 09 Aug, 2022
  • +388 other locations
Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus (Tulip SC)

The purpose of this study is evaluating the efficacy and safety of SC antifrolumab in adult patients with moderate -to-severe SLE despite receiving standard therapy

anifrolumab
lupus
Research Site
 (8.6 away) Contact site
  • 0 views
  • 09 Aug, 2022
  • +75 other locations
A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)

The purpose of this study is to evaluate the efficacy and safety of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants who are heterozygous for F508del and a minimal function mutation (F/MF participants).

tezacaftor
forced expiratory volume
fibrosis
National Jewish Health
 (8.9 away) Contact site
  • 0 views
  • 11 Aug, 2022
  • +121 other locations
A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis (SELECT-GCA)

This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week corticosteroid (CS) taper regimen compared to placebo in combination with a 52-week CS taper regimen, as measured by the proportion of participants in sustained remission at Week …

Denver Arthritis Clinic /ID# 171552
 (9.9 away) Contact site
  • 405 views
  • 09 Aug, 2022
  • +122 other locations