Littleton, Colorado Clinical Trials

A listing of Littleton, Colorado clinical trials actively recruiting patient volunteers.

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Found 98 clinical trials
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the …

classical hodgkin lymphoma
nivolumab
tumor cells
dacarbazine
hypothyroidism
Littleton Adventist Hospital
 (3.9 away) Contact site
  • 101 views
  • 11 Aug, 2022
  • +342 other locations
Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA) (contRAst X)

RA is a chronic, systemic inflammatory autoimmune disease which requires treatment for a long time period, hence it is important to study the long-term safety and efficacy of the continuous treatment with GSK3196165 over several years. This is a Phase 3, multicenter, parallel group treatment and long-term extension study primarily …

folic acid
rheumatic diseases
methotrexate
autoimmune disease
folate
GSK Investigational Site
 (8.9 away) Contact site
  • 290 views
  • 10 Aug, 2022
  • +216 other locations
Study of Efficacy, Safety and Tolerability of CMK389 in Patients With Chronic Pulmonary Sarcoidosis

The purpose of this proof of concept study is to determine whether CMK389 displays the safety and efficacy profile to support further development in chronic pulmonary sarcoidosis.

methotrexate
azathioprine
prednisone
pulmonary sarcoidosis
hydroxychloroquine
Novartis Investigative Site
 (9.8 away) Contact site
  • 17 views
  • 10 Aug, 2022
  • +25 other locations
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of …

absolute neutrophil count
cavity
serum pregnancy test
squamous cell carcinoma of the head and neck
epidermal growth factor
Rocky Mountain Cancer Centers-Littleton
 (1.8 away) Contact site
  • 109 views
  • 11 Aug, 2022
  • +129 other locations
Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery

This phase II/III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works in predicting treatment for patients with stage IIA colon cancer after surgery. ctDNA are circulating tumor cells that are shed by tumors into the blood. Finding ctDNA in the blood means that there …

platelet count
absolute neutrophil count
tumor cells
international normalized ratio
oxaliplatin
Rocky Mountain Cancer Centers-Littleton
 (1.2 away) Contact site
  • 0 views
  • 10 Aug, 2022
  • +593 other locations
A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML) (VIALE-T)

The main objective of this study is to evaluate the efficacy of venetoclax in combination with azacitidine to improve Relapse Free Survival (RFS) in Acute Myeloid Leukemia (AML) participants compared to Best Supportive Care (BSC) when given as maintenance therapy following allogeneic stem cell transplantation (SCT). This study will have …

venetoclax
leukemia
bone marrow procedure
azacitidine
cell transplantation
Colorado Blood Cancer Institute /ID# 215980
 (8.6 away) Contact site
  • 96 views
  • 10 Aug, 2022
  • +112 other locations
A Study of Oral Venetoclax Tablets and Oral Azacitidine Versus Oral Azacitidine as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M)

This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in combination with AZA. Part 3 will be conducted in 2 phases - Dose Finding portion to determine RPTD of venetoclax in combination with CC-486 …

venetoclax
cancer
azacitidine
consolidation chemotherapies
remission
Colorado Blood Cancer Institute /ID# 214280
 (8.6 away) Contact site
  • 49 views
  • 08 Aug, 2022
  • +134 other locations
A Phase 1 Open-label, Multicenter, Dose Escalation Study of the Safety, Tolerability, and PK of HPN217 in Patients With R/R MM

An open-label, Phase 1 study of HPN217 to assess the safety, tolerability and PK in patients with relapsed/ refractory multiple myeloma

platelet count
refractory multiple myeloma
proteasome inhibitor
neutrophil count
measurable disease
Colorado Blood Cancer Institute
 (8.6 away) Contact site
  • 40 views
  • 11 Aug, 2022
  • +14 other locations
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer. The primary hypotheses are that pembrolizumab plus concurrent chemoradiotherapy is superior to placebo plus concurrent chemoradiotherapy with respect to progression-free …

x-rays
pembrolizumab
adenocarcinoma
squamous cell carcinoma
chemoradiotherapy
University of Colorado Health Sciences Center and Hospital ( Site 0028)
 (7.6 away) Contact site
  • 371 views
  • 10 Aug, 2022
  • +141 other locations
Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex (ARISE)

The primary objective of this study is to generate evidence demonstrating the domain specification (via modern psychometric methods), reliability, validity, and responsiveness (within-subject meaningful change) of the Patient-Reported Outcome (PRO) endpoints.

USA001
 (8.5 away) Contact site
  • 35 views
  • 10 Aug, 2022
  • +130 other locations