Denver, Colorado Clinical Trials

A listing of Denver, Colorado clinical trials actively recruiting patient volunteers.

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Found 178 clinical trials
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer. The primary hypotheses are that pembrolizumab plus concurrent chemoradiotherapy is superior to placebo plus concurrent chemoradiotherapy with respect to progression-free …

pembrolizumab
cancer
adenocarcinoma
brachytherapy
external beam radiation therapy
University of Colorado Health Sciences Center and Hospital ( Site 0028)
 (2.0 away) Contact site
  • 371 views
  • 10 Aug, 2022
  • +141 other locations
Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex (ARISE)

The primary objective of this study is to generate evidence demonstrating the domain specification (via modern psychometric methods), reliability, validity, and responsiveness (within-subject meaningful change) of the Patient-Reported Outcome (PRO) endpoints.

USA001
 (2.0 away) Contact site
  • 35 views
  • 10 Aug, 2022
  • +130 other locations
A Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis (STARSCAPE)

This phase III study will evaluate the efficacy, safety and pharmacokinetics (PK) of recombinant human pentraxin-2 (rhPTX-2; PRM-151) zinpentraxin alfa, compared with placebo in participants with idiopathic pulmonary fibrosis (IPF).

diffusion capacity of the lung for carbon monoxide
carbon monoxide
nintedanib
prm-151
lung biopsy
National Jewish Health Medical Center
 (8.2 away) Contact site
  • 18 views
  • 12 Aug, 2022
  • +306 other locations
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary …

pembrolizumab
cancer
paclitaxel
brachytherapy
endometrial carcinoma
University Of Colorado ( Site 3051)
 (8.2 away) Contact site
  • 10 views
  • 10 Aug, 2022
  • +207 other locations
A Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis (STARSCAPE-OLE)

This study will evaulate the long-term safety, efficacy and pharmacokinetics (PK) of recombinant human pentraxin-2 (rhPTX-2; PRM-151) zinpentraxin alfa, administered by intravenous (IV) infusion to participants with idiopathic pulmonary fibrosis (IPF).

prm-151
idiopathic pulmonary fibrosis
National Jewish Health Medical Center
 (8.2 away) Contact site
  • 23 views
  • 11 Aug, 2022
  • +171 other locations
PRV-015 in Gluten-free Diet Non-responsive Celiac Disease (PROACTIVE)

This study will evaluate the efficacy and safety of PRV-015 in adult patients with non-responsive celiac disease (NRCD) who are on a gluten-free diet (GFD).

abdominal pain
bloating
gluten
diarrhea
monoclonal antibodies
Clinical Site
 (2.9 away) Contact site
  • 352 views
  • 10 Aug, 2022
  • +38 other locations
A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children and Young Adults

This is a Phase 1/2/3 study in healthy children and young adults. Dependent upon safety and/or immunogenicity data generated during the course of this study, and the resulting assessment of benefit-risk, the safety, tolerability, and immunogenicity of BNT162b2 in participants <6 months of age may subsequently be evaluated.

Accepts healthy volunteers
Children's Hospital Colorado
 (8.1 away) Contact site
  • 202 views
  • 10 Aug, 2022
  • +125 other locations
Efficacy and Safety of MK-1654 in Infants (MK-1654-004)

The primary objectives of this phase 2b/3 double-blind, randomized, placebo-controlled study are to evaluate the efficacy and safety of MK-1654 in healthy pre-term and full-term infants. It is hypothesized that MK-1654 will reduce the incidence of respiratory syncytial virus (RSV)-associated medically attended lower respiratory infection (MALRI) from Days 1 through …

Accepts healthy volunteers
Children's Hospital Colorado ( Site 0066)
 (8.2 away) Contact site
  • 6 views
  • 11 Aug, 2022
  • +158 other locations
Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients (APPLAUSE-IgAN)

The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of LNP023 at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.

mammogram
nephropathy
treatment regimen
fibrosis
hbeag
Novartis Investigative Site
 (4.1 away) Contact site
  • 11 views
  • 11 Aug, 2022
  • +158 other locations
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

Presbyterian - Saint Lukes Medical Center - Health One
 (1.1 away) Contact site
  • 428 views
  • 11 Aug, 2022
  • +460 other locations