Walnut Creek, California Clinical Trials

A listing of Walnut Creek, California clinical trials actively recruiting patient volunteers.

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Found 247 clinical trials
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation …

myocardial infarction
stemi
infarct
stroke
acute coronary syndrome
8400891 - John Muir Medical Center Walnu
 (2.2 away) Contact site
  • 1118 views
  • 17 Jan, 2021
  • +3410 other locations
Hemodynamic-GUIDEd Management of Heart Failure

The GUIDE-HF IDE clinical trial is intended to demonstrate the effectiveness of the CardioMEMS HF System in an expanded patient population including heart failure (HF) patients outside of the present indication, but at risk for future HF events or mortality.

nt-probnp
medical therapy
brain natriuretic peptide
pro-brain natriuretic peptide
natriuretic peptide
John Muir Medical Center
 (5.2 away) Contact site
  • 661 views
  • 17 Jan, 2021
  • +137 other locations
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating …

vincristine
medulloblastoma
immunohistochemistry
lomustine
cyclophosphamide
Kaiser Permanente-Oakland
 (9.6 away) Contact site
  • 119 views
  • 17 Jan, 2021
  • +130 other locations
Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial

The main purpose of this study is to compare the effects of semaglutide (Ozempic) with the effects of other treatments for type 2 diabetes in a normal practice setting. The participant will be assigned by chance (like flipping a coin) to one of the following treatment groups: Group 1: semaglutide …

semaglutide
antidiabetic agents
drug test
Novo Nordisk Investigational Site
 (2.2 away) Contact site
  • 683 views
  • 25 Nov, 2020
  • +101 other locations
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for …

Kaiser Permanente-Walnut Creek
 (2.8 away) Contact site
  • 247 views
  • 28 Nov, 2020
  • +270 other locations
ILUMIEN IV: OPTIMAL PCI

The objective of this clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent implantation strategy in achieving larger post-PCI lumen dimensions and improving clinical cardiovascular outcomes in patients with high-risk clinical characteristics and/or with high-risk angiographic lesions.

coronary artery disease
stress test
chronic total occlusion
ischemia
unstable angina
John Muir Medical Center
 (5.2 away) Contact site
  • 256 views
  • 26 Jul, 2020
  • +80 other locations
Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

This study will examine the safety and efficacy of pembrolizumab (MK-3475) in combination with chemotherapy in children and young adults with newly diagnosed classical Hodgkin Lymphoma (cHL) who are slow early responders (SERs) to frontline chemotherapy.

vincristine
measurable disease
classical hodgkin lymphoma
dacarbazine
cyclophosphamide
Kaiser Permanente - Oakland ( Site 0047)
 (9.6 away) Contact site
  • 23 views
  • 02 Jan, 2021
  • +66 other locations
Veliparib Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations. Poly adenosine diphosphate (ADP) ribose polymerases (PARPs) are proteins that help repair DNA mutations. PARP inhibitors, such as veliparib, can keep PARP from …

immunohistochemistry
temozolomide
astrocytoma, anaplastic
astrocytoma
glioblastoma multiforme
Kaiser Permanente-Oakland
 (9.6 away) Contact site
  • 403 views
  • 17 Jan, 2021
  • +105 other locations
Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer

This phase III trial studies how well pembrolizumab works in treating patients with bladder cancer that has spread into the deep muscle of the bladder wall (muscle-invasive) or urothelial cancer that has spread from where it started to nearby tissue or lymph nodes (locally advanced). Monoclonal antibodies recognizing and blocking …

Epic Care Cyberknife Center
 (0.7 away) Contact site
  • 836 views
  • 18 Jan, 2021
  • +732 other locations
Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery

This phase IV trial studies the side effects of intraoperative radiation therapy and how well it works in treating patients with breast cancer undergoing breast-conserving surgery. Delivering radiation one time to the area where the tumor was removed while the patient is still in the operating room may kill any …

cancer
breast cancer staging
tumor cells
John Muir Medical Center-Walnut Creek
 (2.2 away) Contact site
  • 101 views
  • 26 Jul, 2020
  • +25 other locations