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San Marino, California Clinical Trials

A listing of San Marino, California clinical trials actively recruiting patient volunteers.

RESULTS

Found (5) clinical trials

A Phase 3 Efficacy Study of AGN-190584 in Participants With Presbyopia

This clinical study will evaluate AGN-190584 in an expanded participant population to establish efficacy, safety, and tolerability versus the vehicle-control when administered, over a 30-day study intervention period, once daily bilaterally in participants with presbyopia.

Phase

3.25 miles

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A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

This Phase Ib/II, open-label, multi-center, single arm study is designed to evaluate the safety and efficacy of AUTO1 in adult patients with B-cell ALL by determining the overall response rate (ORR). Adult patients with relapsed or refractory ALL will be enrolled in both phases of the study. Consented patients will …

Phase

7.49 miles

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Baricitinib Placebo and Antiviral Therapy for the Treatment of Patients With Moderate and Severe COVID-19

PRIMARY OBJECTIVE: I. To determine the efficacy of baricitinib combined with antiviral therapy in participants with COVID-19-related moderate and severe disease in terms of reduction of the proportion of participants requiring invasive mechanical ventilation or dying or requiring anti-IL6 monoclonal antibodies compared to that seen with antiviral alone within 60 …

Phase

7.77 miles

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INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

INCB7839 is an inhibitor of the ADAM (A Disintegrin and Metalloprotease) 10 and 17 proteases. Neuronal activity regulates glioma growth through neuroligin-3 (NLGN3). ADAM 10 is the protease responsible for NLGN3 release into the tumor microenvironment and represents a promising therapeutic target. Pre-clinical studies of INCB7839 in patient-derived pediatric high-grade …

Phase

9.17 miles

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Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

PRIMARY OBJECTIVE: I. Evaluate safety and tolerability of leflunomide in hematopoietic cell transplant (HCT) patients with steroid dependent chronic GvHD (cGvHD). SECONDARY OBJECTIVES: I. Characterize the toxicity profile of leflunomide in patients with steroid dependent cGVHD. II. Obtain preliminary evidence of leflunomide activity against GVHD by estimating the response rate …

Phase

9.71 miles

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