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Northwick Park, United Kingdom Clinical Trials

A listing of Northwick Park, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (641) clinical trials

Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

The primary objective of the IMPRESS Trial will be to compare the proportion of patients undergoing any radical treatment in the two arms of the study. Another primary endpoint is to measure the difference in detection of high risk patients when comparing CT and MRI for all patients. Secondary outcomes ...

Phase N/A

0.05 miles

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Study to Assess Effect of Device and Formulation on Pharmacokinetics (PK) of AZD1402

This study will be a randomized, open-label, 3-period, 3-treatment, single dose, single-center, crossover study. Eighteen healthy male and female subjects will be randomized in this study to ensure that at least 12 subjects are evaluable. A subject will be considered to be evaluable if the subject completes all 3 Treatment ...

Phase

0.12 miles

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Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN)

This is a Phase 1 study of BION-1301, a first-in-class humanized IgG4 anti-a proliferation-inducing ligand (APRIL) monoclonal antibody. The study will be conducted in three parts. Part 1: double-blind, randomized, placebo-controlled, single ascending dose (SAD) in healthy volunteers (HVs). Part 2: double-blind, randomized, placebo-controlled multiple ascending dose (MAD) in HVs. ...

Phase

0.12 miles

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A Study in Healthy Volunteers and Patients With Mild Asthma to Investigate the Safety Anti-inflammatory Effect of Inhaled AZD0449.

Part 1a of the study with six inhaled dose levels of AZD0449 nebulized suspension are planned to be investigated in 6 cohorts. Depending on emerging safety and PK data, up to 3 additional inhaled dose levels (cohorts), within the pre-specified dose range may be added at the discretion of the ...

Phase

0.12 miles

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A Study of Venetoclax in Combination With Low Dose Cytarabine Versus Low Dose Cytarabine Alone in Treatment Naive Patients With Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy

Acute Myeloid Leukaemia (AML) is an aggressive and rare cancer of myeloid cells (a white blood cell responsible for fighting infections). Successful treatment of AML is dependent on what subtype of AML the patient has, and the age of the patient when diagnosed. Venetoclax is an experimental drug that kills ...

Phase

0.13 miles

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Bioequivalence Study of Combination Tablets of Saxagliptin / Dapagliflozin / Metformin XR (Extended-release) and Dapagliflozin / Metformin XR Relative to Individual Components in Healthy Subjects

This study will be an open-label, randomized, 3-period, 3-treatment, single-dose crossover study in healthy subjects (males and females), performed at a single study center, conducted in 3 cohorts. A total of 126 healthy male or female subjects (3 cohorts of 42 subjects each [each cohort consisting of 3 treatments]) will ...

Phase

0.13 miles

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A Phase I Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Food Effect of AZD9898

This study will be a Phase I, randomized, placebo-controlled study in healthy subjects and asthma patients, performed at 2 study centers. The study will consist of 3 parts (Part 1 [SAD in healthy subjects]; Part 2 [SAD in asthma patients]; Part 3 [MAD in healthy subjects under fasted conditions, with ...

Phase

0.13 miles

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Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease

The purpose of the study is to assess the safety and efficacy of JNJ-64304500 in participants with moderately to severely active Crohn's disease.

Phase

0.13 miles

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Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction

The purpose of this study is to evaluate the effect of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction. Cognitive function will be assessed using a comprehensive battery of tests with an evaluation of longitudinal change of cognitive domains including memory, ...

Phase

0.13 miles

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Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis

Vedolizumab is being tested to treat people who have chronic pouchitis. This study will look at the healing of inflammation of ileal pouch in people who take vedolizumab as compared to those receiving a matching placebo. The study will enroll approximately 110 patients. Participants will be randomly assigned to one ...

Phase

0.13 miles

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