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London, United Kingdom Clinical Trials

A listing of London, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (12) clinical trials

Factor VIII Gene Therapy Study in Patients With Hemophilia A

The purpose of this study is to determine the safety and tolerability of the factor VIII gene transfer treatment with BAY 2599023 (DTX201) in individuals with severe hemophilia A.

Phase

0.7 miles

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Moderato System in Patients With Hypertension

Protocol CS-03 Ver 1.1 (NCT02837445) was amended at the advice of the Scientific Advisory to protocol CS-03 Version 3.0 with more stringent hypertension inclusion criteria and different observation intervals for efficacy and safety. In CS-03 Version 3.0 the time of the primary efficacy endpoint was reduced from 6 months to ...

Phase N/A

0.7 miles

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Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease

The study is designed as a multi-site, prospective, 15-month longitudinal, cohort study measuring CSF mHTT in participants with early manifest Stage I or Stage II Huntington's disease (HD).

Phase

1.06 miles

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Gene Therapy for Patients With ADA Adenosine Deaminase (ADA) Deficiency

This is a prospective, non-randomized, single-cohort, longitudinal, single-center, clinical study designed to assess the efficacy and safety of a cryopreserved formulation of OTL-101 (autologous CD34+ hematopoietic stem cells transduced ex vivo with EFS LV encoding for the human ADA gene) administered to ADA-SCID patients between the ages of 30 days ...

Phase

1.08 miles

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Pharmacological Modulation of Belief Salience

Delusions in psychiatry are viewed as a form of aberrant belief. Consequently it is important to understand the cognitive and neural processes involved in beliefs to provide insights into how these processes go awry in the formation of delusions. Beliefs have been defined as 'a disposition to express, assent to, ...

Phase

1.23 miles

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A Translational Study Investigating PD-L1 Expression After Radiotherapy for Non-small Cell Lung Cancer

The purpose of this prospective, multicentre, non-randomised translational study is to provide proof of feasibility of achieving paired biopsies for PD-L1 assessment in patients with NSCLC treated with palliative or radical radiotherapy. This is a non-CTIMP study. All participants will have a minimum of 1 mandatory biopsy (during radiotherapy [irradiated ...

Phase N/A

1.28 miles

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A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants with metastatic castration resistant prostate cancer.

Phase

1.28 miles

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Dysport in Post-Surgical Neuralgia (RESPITE)

The study is designed to determine whether a currently licensed version of botulinum toxin (Dysport) is effective for the treatment of pain that has developed and/or persisted for months or years around the scar of a previous surgical site, and whether this condition could be suitable for the testing of ...

Phase

1.57 miles

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Evaluation of Speckle Tracking Parameters as Predictors of Successful VA SPECKLE ECMO

This project is non-commercial study which aims to assess whether measurements derived through speckle tracking give additional information to conventional echocardiographic parameters (LVOT VTI measurements, etc.) in identifying patients at greatest risk of major clinical events occurring within 30 days after VA ECMO liberation. It is a prospective observational non-blinded ...

Phase N/A

2.22 miles

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Targeted OXYgen Therapy in Critical Illness

The investigators aim is to determine whether revising standard targets for blood oxygen levels in patients requiring artificial ventilation on a critical care unit is feasible and whether this affects specific blood biomarker levels. Investigators in this area of expertise currently lack the information necessary to determine how much oxygen ...

Phase N/A

3.55 miles

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