Hull, United Kingdom Clinical Trials

A listing of Hull, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 71 clinical trials
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A Phase 2 Study of INCMGA00012 in Participants With Squamous Carcinoma of the Anal Canal Who Have Progressed Following Platinum-Based Chemotherapy

The purpose of this study is to assess the efficacy of INCMGA00012 in participants with locally advanced or metastatic squamous carcinoma of the anal canal (SCAC) who have progressed after platinum-based chemotherapy.

platinum-based chemotherapy
chemotherapy regimen
measurable disease
Castle Hill Hospital
 (5.0 away) Contact site
  • 62 views
  • 23 Nov, 2020
  • +23 other locations
A Study of INCMGA00012 in Metastatic Merkel Cell Carcinoma (POD1UM-201)

The purpose of this study is to assess the clinical activity and safety of INCMGA00012 in participants with advanced/metastatic Merkel cell carcinoma (MCC).

Castle Hill Hospital
 (5.0 away) Contact site
  • 21 views
  • 26 Jan, 2021
  • +117 other locations
Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)

This study will evaluate the efficacy and safety of pembrolizumab (MK-3475) with lenvatinib (E7080/MK-7902) vs. docetaxel in participants with metastatic non-small cell lung cancer (NSCLC) and progressive disease (PD) after platinum doublet chemotherapy and treatment with one prior anti-PD-1/PD-L1 monoclonal antibody (mAb). The primary hypotheses of this study are that …

progressive disease
cancer
docetaxel
monoclonal antibodies
ct scan
Hull & East Yorkshire NHS Trust. Castle Hill Hospital ( Site 1108)
 (5.0 away) Contact site
  • 122 views
  • 07 May, 2021
  • +145 other locations
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to …

Novo Nordisk Investigational Site
 (1.1 away) Contact site
  • 0 views
  • 05 May, 2021
  • +201 other locations
Atogepant for Prophylaxis of Migraine in Participants Who Failed Previous Oral Prophylactic Treatments.

This study will assess the safety, tolerability, and efficacy of Atogepant 60 mg compared with placebo in episodic migraines in participants who previously failed 2 to 4 classes of oral prophylactic treatments.

Hull Royal Infirmary
 (0.9 away) Contact site
  • 0 views
  • 27 Apr, 2021
  • +134 other locations
A Comparison of Standard Laser With Micropulse Laser for the Treatment of Diabetic Macular Oedema.

DIAMONDS is a Randomised Controlled Clinical Trial that is being carried out in the UK to determine the clinical effectiveness and cost-effectiveness of micropulse laser, compared with standard laser, for the treatment of diabetic macular oedema.

spectral domain optical coherence tomography
optical coherence tomography
retinopathy
diabetic retinopathy
Hull and East Yorkshire Hospital
 (0.0 away) Contact site
  • 66 views
  • 22 Jan, 2021
  • +11 other locations
Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers

The main purpose of the study is to compare treatment of non-infected venous leg ulcers using ICXP007 combined with four-layer compression bandaging, placebo combined with four-layer compression bandaging and four-layer compression bandaging alone.

ankle brachial pressure index
compression bandaging
reflux
venous stasis
arterial disease
Hull Royal Infirmary
 (0.9 away) Contact site
  • 358 views
  • 07 Nov, 2020
  • +30 other locations
EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

The primary aim of the study is to investigate the effect of empagliflozin on kidney disease progression or cardiovascular death versus placebo on top of standard of care in patients with pre-existing chronic kidney disease

nephropathy
Hull Royal Infirmary
 (0.8 away) Contact site
  • 325 views
  • 20 Apr, 2021
  • +314 other locations
Renal Adjuvant MultiPle Arm Randomised Trial

RATIONALE: The current global standard of care after nephrectomy for localised RCC therefore remains active monitoring (i.e., observation by clinical and radiological means). 30-40% patients with initially localised RCC develop metastatic disease following nephrectomy. Need for adjuvant therapy is most marked in the high risk population where outcomes are predictably …

carcinoma
nephrectomy
cancer
corticosteroids
ct scan
Castle Hill Hospital
 (0.0 away) Contact site
  • 60 views
  • 25 Jan, 2021
  • +34 other locations
Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)

The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trastuzumab in combination with SOC chemotherapy in participants with HER2-positive gastric cancer. The primary hypotheses of the study are that pembrolizumab plus trastuzumab in combination with chemotherapy is superior …

human epidermal growth factor
tegafur
EGFR
erbb2
trastuzumab
Castle Hill Hospital ( Site 1501)
 (5.0 away) Contact site
  • 303 views
  • 05 May, 2021
  • +204 other locations