Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 179 clinical trials
Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST)

Stroke is a leading causes of death and disability. At least 20% of strokes occur during sleep, so- called 'wake up stroke'. Thrombolysis with the clot-busting drug alteplase is effective for acute ischaemic stroke, provided that it is given within 4.5 hours of symptom onset. Patients with wake-up stroke are …

stroke
plasminogen activator
wake up
weakness
plasminogen
Addenbrookes Hospital
 (6.1 away) Contact site
  • 148 views
  • 31 Jan, 2022
  • +69 other locations
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC) (CompARE)

CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.

cancer
serum pregnancy test
renal function test
oropharyngeal cancer
carcinoma
Addenbrooke's Hospital
 (6.1 away) Contact site
  • 4 views
  • 03 Mar, 2022
  • +29 other locations
Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma (FRONTIER-3)

Study D9181C00001 is a Phase II, randomised, double-blind, placebo-controlled, parallel group, proof of concept study to evaluate the efficacy, safety, pharmacokinetics (PK) and immunogenicity of MEDI3506 in adult participants with uncontrolled moderate to severe asthma on standard of care (SOC). Up to approximately 80 sites globally will participate in this …

Research Site
 (6.1 away) Contact site
  • 456 views
  • 26 Mar, 2022
  • +64 other locations
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) (ELATIVE)

The main objective of the study is to evaluate the effect of daily oral administration of 80mg elafibranor on cholestasis (impairment of bile formation and/or bile accumulation) in patients with PBC and inadequate response or intolerance to Ursodeoxycholic Acid (UCDA)

biopsy of liver
elafibranor
cholestasis
cholangitis
ursodiol
Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital
 (6.1 away) Contact site
  • 0 views
  • 18 Apr, 2022
  • +107 other locations
Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma (FIDES-03)

The purpose of this study is to evaluate the efficacy of derazantinib monotherapy or derazantinib in combination with paclitaxel, ramucirumab, or atezolizumab in patients with HER2-negative adenocarcinoma of the stomach or gastro-esophageal junction harboring FGFR2 genetic aberrations (GA).

Addenbrooke's Hospital
 (4.5 away) Contact site
  • 0 views
  • 07 Mar, 2022
  • +78 other locations
Breast Screening - Risk Adaptive Imaging for Density

BRAID is a randomised, multi-centre study assessing the impact of supplementary imaging in the detection of breast cancer in women participating in the UK national breast screening programme who have dense breast tissue.

Cambridge University Hospitals NHS Foundation Trust
 (4.1 away) Contact site
  • 21 views
  • 26 Jan, 2021
  • +3 other locations
Nasal Oxygen Therapy After Cardiac Surgery (NOTACS)

NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation) increases days at home in the first 90 days after surgery, for adult patients undergoing cardiac surgery who are at high risk of postoperative pulmonary complications. The study also incorporates …

body mass index
pulmonary disease
Royal Papworth Hospital NHS Foundation Trust
 (5.9 away) Contact site
  • 0 views
  • 08 Apr, 2022
  • 1 location
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1) (BOSTON-1)

The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in single lung transplant recipients.

obstructive lung disease
tacrolimus
corticosteroids
prednisone
therapeutic agents
Royal Papworth Hospital NHS Foundation Trust
 (5.9 away) Contact site
  • 3 views
  • 24 Apr, 2022
  • +25 other locations
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-2) (BOSTON-2)

The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in double lung transplant recipients.

obstructive lung disease
tacrolimus
corticosteroids
prednisone
therapeutic agents
Royal Papworth Hospital
 (4.8 away) Contact site
  • 18 views
  • 24 Apr, 2022
  • +39 other locations
Use of Blood Ketone Meters to Improve Ambulance Hyperglycaemia Care

In this KARMA2 feasibility study the investigators are testing whether ambulance staff can reliably and safely identify patients at high risk of diabetic ketoacidosis using blood ketone meters and start fluid (saline) therapy before arriving at hospital. The investigators aim to include 800 patients in this stepped wedge control study …

Accepts healthy volunteers
diabetic ketoacidosis
East of England Ambulance Service NHS Trust
 (8.6 away) Contact site
  • 0 views
  • 06 Nov, 2021
  • 1 location