Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 179 clinical trials
Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART)

RATIONALE: The current global standard of care after nephrectomy for localised RCC therefore remains active monitoring (i.e., observation by clinical and radiological means). 30-40% patients with initially localised RCC develop metastatic disease following nephrectomy. Need for adjuvant therapy is most marked in the high risk population where outcomes are predictably …

ct scan
serum pregnancy test
platelet count
Addenbrookes Hospital
 (4.8 away) Contact site
  • 14 Feb, 2022
  • +34 other locations
A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis (MAESTRO-NASH)

A double-blind placebo controlled randomized Phase 3 study to determine if 80 or 100 mg of MGL-3196 as compared with placebo resolves NASH on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease

ballooning degeneration
liver disease
hepatic fibrosis
Cambridge University Hospitals NHS Foundation Trust
 (4.8 away) Contact site
  • 07 Feb, 2022
  • +214 other locations
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation (PRESTIGE-AF)

Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain. Blockage of brain arteries by these clots is a major cause of stroke. This type of stroke is called an ischaemic …

brain imaging
apixaban oral tablet
Cambridge University Hospitals NHS Trust
 (4.8 away) Contact site
  • 11 Feb, 2022
  • +15 other locations
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial) (A2B)

Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free. However, keeping patients too deeply sedated can make their ICU stay longer, can cause ICU confusion (delirium) and afterwards may cause distressing memories. …

Cambridge University Hospitals NHS Foundation Trust
 (4.8 away) Contact site
  • 09 Apr, 2022
  • +27 other locations
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (ENRICH-AF)

To assess whether edoxaban (60/30 mg daily) compared to non-antithrombotic medical therapy (either no antithrombotic therapy or antiplatelet monotherapy) reduces the risk of stroke (composite of ischemic, hemorrhagic and unspecified stroke) in high-risk atrial fibrillation (CHA2DS2-VASc 2) patients with previous intracranial hemorrhage.

vascular disease
Cambridge University Hospitals NHS Foundation Trust
 (4.1 away) Contact site
  • 16 Feb, 2022
  • +138 other locations
Routine Cardiac Screening in Sarcoidosis Patients (PAPLAND)

This protocol is an unblended randomized screening trial will have consecutive patients with no suggestion of cardiac sarcoidosis according to usual screening enroll in an enhanced screening protocol. The routine clinical care is to gather patient's history of symptoms and under go an ECG. If a patient has an abnormal …

cardiac sarcoidosis
Royal Papworth Hospital
 (4.8 away) Contact site
  • 15 Feb, 2022
  • +4 other locations
N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T)

This is a multinational, multicenter, open-label, rater-blinded prospective Phase II study which will assess the safety and efficacy of N-Acetyl-L-Leucine (IB1001) for the treatment of Ataxia-Telangiectasia (A-T). There are two phases to this study: the Parent Study, and the Extension Phase. The Parent Study evaluates the safety and efficacy of …

Royal Papworth Hospital NHS Foundation Trust
 (6.0 away) Contact site
  • 18 Feb, 2022
  • +4 other locations
OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial (OPTIMAS)

OPTIMAS is a large, prospective, partially blinded randomised controlled trial of early (within 4 days [96hrs]) or standard (between day 7 and day 14 after stroke onset) initiation of anticoagulation after stroke in patients with atrial fibrillation (AF), using any licensed dose of a direct oral anticoagulant (DOAC). The trial …

anticoagulation therapy
ischemic stroke
electrocardiographic monitoring
12 lead ECG
Addenbrooke's Hospital NHS Trust
 (6.1 away) Contact site
  • 20 Feb, 2022
  • +43 other locations
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia (Myechild01)

The main purpose of this study is : To establish which number of doses of gemtuzumab ozogamicin (up to a maximum of 3 doses) is tolerated and can be safety delivered in combination with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal …

myeloablative conditioning
ejection fraction
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
 (6.1 away) Contact site
  • 26 Jan, 2022
  • +68 other locations
Platinum and Polyadenosine 5'Diphosphoribose Polymerisation (PARP) Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer (TNBC) and/or Germline BRCA (gBRCA) Positive Breast Cancer (PARTNER)

This neoadjuvant trial for patients with TNBC and/or gBRCA breast cancer, aims to investigate the safety and efficacy (improvement in pathological Complete Response at surgery) of concurrent platinum-based chemotherapy with olaparib an inhibitor of the PARP enzyme (PARPi).

invasive breast cancer
adjuvant therapy
triple negative breast cancer
Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge
 (6.1 away) Contact site
  • 29 Jan, 2022
  • 1 location