Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
I am looking for
added new label for I am looking for
Advanced Filters
Found 219 clinical trials
A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours. Anyone diagnosed with a minor stroke faces the possibility of long-term disability and even death, regardless of treatment. Stroke symptoms such as weakness, difficulty …

transient ischemic attack
Addenbrooke Hospital
 (4.8 away) Contact site
  • 26 Jan, 2021
  • +58 other locations
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

The purpose of this study is to evaluate the clinical efficacy (GALAXI 1), clinical and endoscopic efficacy (GALAXI 2 and GALAXI 3) and safety of guselkumab in participants with Crohn's disease.

fistulising crohn's disease
abdominal pain
Addenbrooke's Hospital
 (6.1 away) Contact site
  • 07 Sep, 2021
  • +806 other locations
A Multicenter Randomized Double-Blind Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis

The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the appropriate induction dose of risankizumab for further evaluation in Sub-Study 2. The objective of Sub-Study 2 is to …

Cambridge University Hospital NHS Foundation Trust Addenbrooke's Hospital /ID# 158040
 (6.0 away) Contact site
  • 26 Sep, 2021
  • +926 other locations
Macular Edema Ranibizumab v. Intravitreal Anti-inflammatory Therapy Trial

The Macular Edema Ranibizumab v. Intravitreal anti-inflammatory Therapy (MERIT) Trial will compare the relative efficacy and safety of intravitreal methotrexate, intravitreal ranibizumab, and the intravitreal dexamethasone implant for the treatment of uveitic macular edema persisting or reoccurring after an intravitreal corticosteroid injection. MERIT is a parallel design (1:1:1), randomized comparative …

fluorescein angiography
macular edema
Cambridge University Hospitals NHS Foundation Trust
 (6.1 away) Contact site
  • 07 Aug, 2021
  • +32 other locations
The Effect of Higher Protein Dosing in Critically Ill Patients

The investigator will investigate the effects of higher protein/amino acid dosing (2.2 g/kg/d) vs usual protein/amino acid dosing (1.2 g/kg/d) on clinical outcomes in nutritionally high risk ill patients.

amino acids
severe malnutrition
Addenbrooke's Hospital
 (4.5 away) Contact site
  • 02 Jul, 2021
  • +93 other locations
Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma

Oropharyngeal Squamous Cell Carcinoma (OPSCC) arises in the soft palate, tonsils, base of tongue, pharyngeal wall, and the vallecula. Most of the patients with early stage OPSCC are usually cured. Treatment of early stage OPSCC can be successfully achieved with primary surgery including neck dissection, as indicated, or with definitive …

oropharyngeal carcinoma
head and neck cancer
platelet count
extracapsular extension
intensity-modulated radiation therapy
Cambridge University Hospital NHS - Addenbrookes Hospital
 (4.8 away) Contact site
  • 14 May, 2021
  • +31 other locations
Comparison of Optimal Hypertension Regimens

High blood pressure (Hypertension) is extremely common and is a major cause of heart disease, kidney disease and stroke. One in three of the UK (United Kingdom) population will require treatment for hypertension at some point in their lives. A healthy lifestyle alone is often not enough to control blood …

antihypertensive drugs
Cambridge University Hospitals NHS Foundation Trust
 (6.1 away) Contact site
  • 08 Aug, 2021
  • +13 other locations
A Study to Evaluate PF-06730512 in Adults With Focal Segmental Glomerulosclerosis (FSGS)

The purpose of this Phase 2 adaptive study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of PF-06730512 following multiple intravenous infusion in adult subjects with FSGS.

tubulointerstitial fibrosis
immunosuppressive agents
total protein
focal segmental glomerulosclerosis
glomerular filtration rate
Cambridge University Hospitals NHS Foundation Trust
 (4.1 away) Contact site
  • 14 Aug, 2021
  • +106 other locations
Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A

The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).

lung carcinoma
systemic therapy
Novartis Investigative Site
 (6.1 away) Contact site
  • 21 Sep, 2021
  • +416 other locations
Study of Chemoradiotherapy in Oesophageal Cancer Including PET Response and Dose Escalation

Research has shown that increasing the dose of radiotherapy improves outcomes in patients with lung and head and neck cancers. This study aims to see whether this is also the case for patients with tumour of the oesophagus. This trial will compare the effects of the standard dose of radiotherapy …

kidney function test
esophagus cancer
endoscopic ultrasound
Addenbrooke's Hospital
 (4.8 away) Contact site
  • 22 Jan, 2021
  • +21 other locations