Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 175 clinical trials
NTLA-2002 in Adults With Hereditary Angioedema (HAE) (NTLA-2002)

This study will be conducted to evaluate the safety, tolerability, activity, pharmacokinetics, and pharmacodynamics of NTLA-2002 in adults with Hereditary Angioedema (HAE).

angioedema
Cambridge University Hospitals NHS Foundation Trust Addenbrookes Hospital
 (5.3 away) Contact site
  • 0 views
  • 26 Jul, 2022
  • +2 other locations
Functional and Ultrasound Guided Resection of Glioblastoma (FUTURE-GB)

Functional and ultrasound-guided resection of glioblastoma: assessing the use of additional imaging during surgery to improve outcomes for patients with glioblastoma brain tumours

Addenbrookes Hospital, Cambridge University NHSFT
 (6.0 away) Contact site
  • 0 views
  • 18 Jun, 2022
  • +16 other locations
DAYBREAK: Phase 2 Study in Patients With Specific Gene Defects in the MC4R Pathway

2 stage (open-label run-in, followed by randomized, double-blind, placebo-controlled withdrawal), study trial of setmelanotide in patients with obesity and specific gene defects variants in the melanocortin-4 receptor (MC4R) pathway.

University of Cambridge
 (6.1 away) Contact site
  • 0 views
  • 13 Jul, 2022
  • +13 other locations
A Study to Assess RXC004 Efficacy in Advanced Solid Tumours After Progression on Standard of Care (SoC) Therapy (PORCUPINE2)

This study is to evaluate the preliminary efficacy and safety of RXC004 monotherapy in advanced solid tumours that have progressed following SoC treatment.

Cambridge University Hospital NHS Foundation Trust
 (4.8 away) Contact site
  • 0 views
  • 13 May, 2022
  • +9 other locations
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (ENRICH-AF)

To assess whether edoxaban (60/30 mg daily) compared to non-antithrombotic medical therapy (either no antithrombotic therapy or antiplatelet monotherapy) reduces the risk of stroke (composite of ischemic, hemorrhagic and unspecified stroke) in high-risk atrial fibrillation (CHA2DS2-VASc 2) patients with previous intracranial hemorrhage.

fibrillation
atrial fibrillation
stroke
edoxaban
vascular disease
Cambridge University Hospitals NHS Foundation Trust
 (4.1 away) Contact site
  • 15 views
  • 16 Feb, 2022
  • +139 other locations
Precision-Panc Master Protocol: Personalising Treatment for Pancreatic Cancer

The Precision-Panc Master Protocol is a "portal" protocol for patients with known or suspected pancreatic cancer to be accrued through multiple centres in the UK, with the option of being subsequently enrolled into PRIMUS (Pancreatic canceR Individualised Multi-arm Umbrella Studies) examining different treatment regimens and/or biomarker development. Eligible patients will …

pancreatic ductal adenocarcinoma
metastasis
breast ductal carcinoma
cancer chemotherapy
adenocarcinoma
Addenbrooke's Hospital
 (4.8 away) Contact site
  • 23 views
  • 26 May, 2022
  • +28 other locations
N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T)

This is a multinational, multicenter, open-label, rater-blinded prospective Phase II study which will assess the safety and efficacy of N-Acetyl-L-Leucine (IB1001) for the treatment of Ataxia-Telangiectasia (A-T). There are two phases to this study: the Parent Study, and the Extension Phase. The Parent Study evaluates the safety and efficacy of …

Royal Papworth Hospital NHS Foundation Trust
 (6.0 away) Contact site
  • 2 views
  • 18 Feb, 2022
  • +4 other locations
OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial (OPTIMAS)

OPTIMAS is a large, prospective, partially blinded randomised controlled trial of early (within 4 days [96hrs]) or standard (between day 7 and day 14 after stroke onset) initiation of anticoagulation after stroke in patients with atrial fibrillation (AF), using any licensed dose of a direct oral anticoagulant (DOAC). The trial …

atrial fibrillation
electrocardiogram
holter monitor
ischemic stroke
stroke
Addenbrooke's Hospital NHS Trust
 (6.1 away) Contact site
  • 76 views
  • 20 Feb, 2022
  • +43 other locations
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several …

doxorubicin
imatinib
vincristine
inotuzumab
dexamethasone
Addenbrooke's Hospital, Cambridge
 (6.1 away) Contact site
  • 73 views
  • 15 Jun, 2022
  • +60 other locations
Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation (NOTUS)

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by Annualized rate of acute moderate or severe COPD exacerbation (AECOPD) Secondary Objectives: To evaluate the effect of dupilumab administered every 2 weeks on Pre-bronchodilator …

bronchitis
pulmonary function test
muscarinic antagonists
bronchodilator
cough
Investigational Site Number :8260003
 (6.1 away) Contact site
  • 314 views
  • 02 Jul, 2022
  • +319 other locations