Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 175 clinical trials
BioVentrix Revivent TC System Clinical Study

A prospective, multi-center, dual-arm pivotal study of the BioVentrix Revivent TC System, with 2:1 study vs. active concurrent control group allocation ratio. This study will include 126 patients of which 84 patients will be treated with the investigational device and 42 patients will be included in an active control group.

heart failure
ejection fraction
medical therapy
6-minute walk test
Papworth Hospital NHS Foundation Trust
 (5.9 away) Contact site
  • 20 Mar, 2021
  • +36 other locations
The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial (plasmaMATCH)

plasmaMATCH is a multi-centre phase IIa umbrella trial platform consisting of a ctDNA screening component and a therapeutic component. plasmaMATCH aims to assess whether ctDNA screening can be used to detect patient subgroups who will be sensitive to targeted therapies, and will also assess the safety and activity of the …

her2/neu-positive breast cancer
lhrh analogue
measurable disease
invasive breast cancer
breast carcinoma
Addenbrooke's Hospital
 (4.8 away) Contact site
  • 25 Feb, 2022
  • +17 other locations
HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID)

HEAL-COVID is jointly Sponsored by Cambridge University Hospitals NHS Foundation Trust and The University of Cambridge. The acute effects of COVID-19 are now well described. Evidence is emerging of serious longer-term complications occurring in the convalescent phase of the illness in a significant proportion of patients particularly cardiovascular and pulmonary …

Addenbrookes Hospital
 (4.8 away) Contact site
  • 02 Aug, 2021
  • 1 location
Immunogenicity and Safety of BPZE1 Intranasal Pertussis Vaccine in Healthy School-age Children

This study evaluates the safety and immunogenicity of the BPZE1 live, attenuated pertussis vaccine, intended to prevent nasopharyngeal colonization and pertussis disease, and compares BPZE1 vaccine vs Boostrix vaccine vs both BPZE1 and Boostrix vaccines. This is a multi-center, randomized, placebo- and active-comparator-controlled study in healthy, school-age children with a …

Accepts healthy volunteers
Addenbrooke's Hospital
 (4.5 away) Contact site
  • 28 Jul, 2022
  • +3 other locations
A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

This is a Phase Ib/II study to evaluate the safety and efficacy of autologous T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 in adult patients with relapsed or refractory B cell acute lymphoblastic leukemia (ALL).

Cambridge University Hospitals NHS Foundation Trust
 (4.1 away) Contact site
  • 07 Jun, 2022
  • +32 other locations
ATL001 in Patients With Advanced Unresectable or Metastatic NSCLC

This is a first-in-human, open-label, multi-centre, phase I/IIa study to characterise the safety and clinical activity autologous clonal neoantigen reactive T cells (cNeT) administered intravenously in adults with advanced non-small cell lung cancer (NSCLC).

Cambridge University Hospitals NHS Foundation Trust
 (4.8 away) Contact site
  • 13 Feb, 2022
  • +9 other locations
A Study of the Safety and Tolerability of GTX-102 in Children With Angelman Syndrome (KIK-AS)

The primary objective of the study is to evaluate the safety and tolerability of multiple-ascending doses of GTX-102 administered by IT injection to patients with AS.

Cambridge University Hospitals
 (4.8 away) Contact site
  • 09 Aug, 2022
  • +6 other locations
Abiraterone Acetate in Combination With Tildrakizumab (ACTIon)

The purpose of this study is to find out the side effects and safety of a combination of the anti-IL23 targeting monoclonal antibody tildrakizumab in combination with abiraterone acetate in men with metastatic castration resistant prostate cancer and to determine the most appropriate dose of this combination. In the Phase …

Accepts healthy volunteers
Addenbrooke's Hospital
 (4.5 away) Contact site
  • 13 May, 2022
  • +3 other locations
CM-101 in PSC Patients -The SPRING Study

This study is designed to assess the safety, tolerability and activity of CM-101 in patients with Primary Sclerosing Cholangitis (PSC).

Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital - site P09
 (4.8 away) Contact site
  • 11 Sep, 2021
  • +17 other locations
Positioning Imatinib for Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) is a rare condition in which a narrowing of blood vessels carrying blood through the lungs puts an increased work load on the heart; it has to work harder to pump blood through the lungs. While current treatments relieve some of the symptoms, they do not …

Royal Papworth Hospital, Royal Papworth Hospital NHS Foundation Trust
 (6.0 away) Contact site
  • 27 Sep, 2021
  • +7 other locations