Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 172 clinical trials
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Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

The purpose of this study is to determine whether FT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy in subjects with narcolepsy.

multiple sleep latency test
stimulant
sodium oxybate
cataplexy
sleep disorder
REspiratory Support and Sleep Centre at Papworth Hospital
 (5.9 away) Contact site
  • 363 views
  • 10 Jul, 2018
  • +52 other locations
The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial (plasmaMATCH)

plasmaMATCH is a multi-centre phase IIa umbrella trial platform consisting of a ctDNA screening component and a therapeutic component. plasmaMATCH aims to assess whether ctDNA screening can be used to detect patient subgroups who will be sensitive to targeted therapies, and will also assess the safety and activity of the …

serum pregnancy test
breast carcinoma
ovarian suppression
gnrh
targeted therapy
Addenbrooke's Hospital
 (4.8 away) Contact site
  • 315 views
  • 25 Feb, 2022
  • +17 other locations
Postoperative Immunotherapy vs Standard Chemotherapy for Gastric Cancer With High Risk for Recurrence (VESTIGE)

The primary objective of the trial is to investigate if nivolumab plus ipilimumab given as adjuvant treatment improve disease free survival (DFS) in patients with stage Ib-IVa gastric and esophagogastric junction adenocarcinoma and high risk of recurrence (defined by ypN1-3 and/or R1 status) following neoadjuvant chemotherapy and resection. Other study …

Cambridge University Hospital NHS
 (4.8 away) Contact site
  • 33 views
  • 26 Feb, 2022
  • +19 other locations
A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing (PRAETORIAN-DFT)

This study will test the hypothesis that implantation of a subcutaneous implantable cardioverter defibrillator (S-ICD) without performing a defibrillation test is non-inferior to S-ICD implant with a defibrillation test with regards to the primary endpoint failed first shock in a spontaneous arrhythmia episode when implant position is confirmed with PRAETORIAN …

Royal Papworth Hospital NHS Foundation Trust
 (4.8 away) Contact site
  • 115 views
  • 03 Mar, 2022
  • +31 other locations
VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

Global, Post-Market, Prospective, Multi-Center, Randomized Controlled Trial of the VenaSeal™ Closure System vs. Surgical Stripping or Endothermal Ablation (ETA) for the Treatment of Early and Advanced Stage Superficial Venous Disease

Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital
 (4.8 away) Contact site
  • 23 views
  • 10 Mar, 2022
  • +23 other locations
BioVentrix Revivent TC System Clinical Study

A prospective, multi-center, dual-arm pivotal study of the BioVentrix Revivent TC System, with 2:1 study vs. active concurrent control group allocation ratio. This study will include 126 patients of which 84 patients will be treated with the investigational device and 42 patients will be included in an active control group.

heart failure
ejection fraction
medical therapy
6-minute walk test
Papworth Hospital NHS Foundation Trust
 (5.9 away) Contact site
  • 88 views
  • 20 Mar, 2021
  • +36 other locations
Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in patients with bronchiectasis will demonstrate clinical safety and efficacy related to improved mucociliary clearance with reduced bacterial colonization as potential drivers of airway obstruction, reduced airway inflammation, exacerbations and mucus …

macrolides
cystic fibrosis
fibrosis
combinations
mucolytics
Novartis Investigative Site
 (4.5 away) Contact site
  • 6 views
  • 22 Apr, 2022
  • +13 other locations
Immunogenicity and Safety of BPZE1 Intranasal Pertussis Vaccine in Healthy School-age Children

This study evaluates the safety and immunogenicity of the BPZE1 live, attenuated pertussis vaccine, intended to prevent nasopharyngeal colonization and pertussis disease, and compares BPZE1 vaccine vs Boostrix vaccine vs both BPZE1 and Boostrix vaccines. This is a multi-center, randomized, placebo- and active-comparator-controlled study in healthy, school-age children with a …

vaccination
diphtheria
tetanus
Accepts healthy volunteers
boostrix
Addenbrooke's Hospital
 (4.5 away) Contact site
  • 0 views
  • 25 Mar, 2022
  • +2 other locations
HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID)

HEAL-COVID is jointly Sponsored by Cambridge University Hospitals NHS Foundation Trust and The University of Cambridge. The acute effects of COVID-19 are now well described. Evidence is emerging of serious longer-term complications occurring in the convalescent phase of the illness in a significant proportion of patients particularly cardiovascular and pulmonary …

Addenbrookes Hospital
 (4.8 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • 1 location
Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock

Cardiogenic shock (CGS) affects up to 10% of patients suffering acute coronary syndrome. It has a 30 day mortality of 45-50%. No pharmacological nor intervention/device trials have had any impact on this mortality in the last 20 years. The EURO SHOCK Trial (supported by the European Union Horizons 2020 programme) …

Papworth Hospital
 (5.9 away) Contact site
  • 0 views
  • 12 May, 2021
  • +46 other locations