Hardwick,, United Kingdom Clinical Trials

A listing of Hardwick,, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 220 clinical trials
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Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

The purpose of this study is to determine whether FT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy in subjects with narcolepsy.

sodium oxybate
multiple sleep latency test
sleep disorder
somnolence
stimulant
REspiratory Support and Sleep Centre at Papworth Hospital
 (5.9 away) Contact site
  • 16 views
  • 10 Jul, 2018
  • +52 other locations
Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1)

The purpose of this study is to to assess the safety and tolerability of pirfenidone 2403 mg/day for the treatment of RA-associated interstitial lung disease.

Papworth Hospital NHS Foundation Trust
 (5.9 away) Contact site
  • 207 views
  • 23 Jan, 2021
  • +30 other locations
Postoperative Immunotherapy vs Standard Chemotherapy for Gastric Cancer With High Risk for Recurrence

The primary objective of the trial is to investigate if nivolumab plus ipilimumab given as adjuvant treatment improve disease free survival (DFS) in patients with stage Ib-IVa gastric and esophagogastric junction adenocarcinoma and high risk of recurrence (defined by ypN1-3 and/or R1 status) following neoadjuvant chemotherapy and resection. Other study …

Cambridge University Hospital NHS
 (4.8 away) Contact site
  • 33 views
  • 10 Feb, 2021
  • +24 other locations
The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial

plasmaMATCH is a multi-centre phase IIa umbrella trial platform consisting of a ctDNA screening component and a therapeutic component. plasmaMATCH aims to assess whether ctDNA screening can be used to detect patient subgroups who will be sensitive to targeted therapies, and will also assess the safety and activity of the …

olaparib
locally advanced breast cancer
measurable disease
invasive breast cancer
her2/neu-positive breast cancer
Addenbrooke's Hospital
 (4.8 away) Contact site
  • 313 views
  • 22 Jan, 2021
  • +17 other locations
Safety Tolerability and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis

The primary objective of this study is to evaluate whether cilofexor reduces the risk of fibrosis progression among non-cirrhotic adults with primary sclerosing cholangitis (PSC).

fibrosis
cilofexor
platelet count
Cambridge University Hospitals NHS Foundation Trust
 (6.1 away) Contact site
  • 83 views
  • 25 Jul, 2021
  • +231 other locations
A Study to Test the Pharmacokinetics Efficacy and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures

The purpose of the study is to evaluate the pharmacokinetics (PK) of brivaracetam (BRV) in neonates who have seizures that are not adequately controlled with previous antiepileptic drug (AED) treatment, and to identify the optimal BRV dose (Exploratory Cohort) for the treatment of subjects enrolled into the Confirmatory Cohorts of …

N01349 251
 (4.8 away) Contact site
  • 1 views
  • 03 Jul, 2021
  • +15 other locations
Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet versus usual standard of care in patients with intracranial hemorrhage anticoagulated with a direct oral anticoagulant

Addenbrooke's Hospital
 (6.1 away) Contact site
  • 19 views
  • 17 Jul, 2021
  • +180 other locations
BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma

The aim of this clinical trial is to assess the effect of treatment with a monoclonal antibody called atezolizumab in patients diagnosed with a type of lung cancer called malignant pleural mesothelioma. The efficacy (whether the treatment works), safety and tolerability (side effects of treatment) of atezolizumab plus bevacizumab in …

Addenbrooke's Hospital
 (4.8 away) Contact site
  • 57 views
  • 14 May, 2021
  • +53 other locations
IRCI Gynae Sarcomas High Grade Uterine Sarcoma

This study aims to investigate a drug called Cabozantinib which belongs to a family of drugs that have effects on tumour growth, blood supply, invasion and spread. Therefore, we want to find out whether taking cabozantinib after treatment with surgery and chemotherapy is effective and safe for patients who responded …

Cambridge University Hospital NHS - Addenbrookes Hospital
 (4.8 away) Contact site
  • 52 views
  • 23 Jan, 2021
  • +9 other locations
A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing

This study will test the hypothesis that implantation of a subcutaneous implantable cardioverter defibrillator (S-ICD) without performing a defibrillation test is non-inferior to S-ICD implant with a defibrillation test with regards to the primary endpoint failed first shock in a spontaneous arrhythmia episode when implant position is confirmed with PRAETORIAN …

Royal Papworth Hospital NHS Foundation Trust
 (4.8 away) Contact site
  • 79 views
  • 25 Jan, 2021
  • +40 other locations