Dundee, United Kingdom Clinical Trials

A listing of Dundee, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 65 clinical trials
A Study of Apalutamide in Participants With High-Risk Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy (RP) with pelvic lymph node dissection (pLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and …

androgen suppression
prostatectomy
metastasis
apalutamide
antiandrogen therapy
Ninewells Hospital
 (2.4 away) Contact site
  • 291 views
  • 02 Jun, 2021
  • +352 other locations
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

stroke
diabetes
arterial disease
myocardial infarction
infarct
Research Site
 (0.8 away) Contact site
  • 536 views
  • 20 Jun, 2021
  • +1330 other locations
Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients

ICON 9 will assess the efficacy, safety and tolerability of maintenance olaparib in combination with cediranib compared to maintenance olaparib alone following a response to platinum-based chemotherapy in women with relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer. Prognostic and predictive factors will be studied from tumour and blood samples.

neutrophil count
cancer of the ovary
cancer antigen 125
recurrent disease
tumor debulking
Ninewells Hospital
 (0.8 away) Contact site
  • 392 views
  • 10 Jun, 2021
  • +44 other locations
Precision-Panc Master Protocol: Personalising Treatment for Pancreatic Cancer

The Precision-Panc Master Protocol is a "portal" protocol for patients with known or suspected pancreatic cancer to be accrued through multiple centres in the UK, with the option of being subsequently enrolled into PRIMUS (Pancreatic canceR Individualised Multi-arm Umbrella Studies) examining different treatment regimens and/or biomarker development. Eligible patients will …

adenocarcinoma
cancer chemotherapy
breast ductal carcinoma
pancreatic ductal adenocarcinoma
metastasis
Western General
 (36.0 away) Contact site
  • 23 views
  • 26 Jan, 2021
  • +21 other locations
ABILITY Diabetes Global

To compare in diabetic patients eligible for percutaneous coronary intervention (PCI) with minimal exclusion criteria, the efficacy and safety of Abluminus DES+ sirolimus- eluting stents (SES) versus XIENCE Everolimus-Eluting Stents (EES). At least 40% of patients are expected to be affected by multivessel coronary artery disease and 30% with acute …

stable angina
glucose tolerance test
plasma glucose
angina pectoris
hba1c
Golden Jubilee National Hospital
 (67.2 away) Contact site
  • 0 views
  • 25 Jan, 2021
  • +85 other locations
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy

The XEN1101 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and tolerability of increasing doses of XEN1101 administered as adjunctive treatment in adult patients diagnosed with focal epilepsy, followed by an optional open-label extension (OLE).

adjunctive treatment
adjunctive therapy
seizure
Ninewells Hospital and Medical School Tayside NHS Board
 (0.8 away) Contact site
  • 104 views
  • 25 Jan, 2021
  • +81 other locations
Evaluation of Efficacy and Safety of Belantamab Mafodotin Bortezomib and Dexamethasone Versus Daratumumab Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

This is a Phase 3, randomized, open-label study designed to evaluate safety and efficacy of belantamab mafodotin in combination with bortezomib/dexamethasone (Arm A) versus daratumumab in combination with bortezomib/dexamethasone (Arm B) in the participants with relapsed recurrent multiple myeloma.

cancer
refractory multiple myeloma
bortezomib
daratumumab
dexamethasone
GSK Investigational Site
 (0.8 away) Contact site
  • 17 views
  • 11 Jun, 2021
  • +137 other locations
A Treatment Study Protocol for Participants 1-45 Years With Acute Lymphoblastic Leukaemia

ALLTogether collects the experience of previously successful treatment of children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several randomised …

vincristine
dexamethasone
inotuzumab
doxorubicin
imatinib
Ninewells Hospital, Dundee
 (0.8 away) Contact site
  • 27 views
  • 27 Jan, 2021
  • +101 other locations
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2+ Gastric Cancer (DESTINY-Gastric03)

DESTINY-Gastric03 will investigate the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of trastuzumab deruxtecan (T-DXd) alone or in combination with chemotherapy and/or durvalumab in HER2-positive advanced/metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma patients. Study hypotheses: Combination of T-DXd with cytotoxic chemotherapy and/or durvalumab administered to subjects at the recommended phase 2 …

cancer chemotherapy
metastatic adenocarcinoma
metastasis
fluorouracil
trastuzumab
Research Site
 (0.8 away) Contact site
  • 0 views
  • 19 Jun, 2021
  • +67 other locations
A Study to Assess the Safety and Efficacy of Guanfacine Hydrochloride Prolonged Release (SPD503) in Children and Adolescents Aged 6 to 17 Years With Attentiondeficit/Hyperactivity Disorder (ADHD)

This interventional multicenter dose-optimization Phase IV PASS conducted in Europe and the USA evaluates the comparative long-term safety and efficacy of SPD503 in children and adolescents aged 6 to 17 years diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) for whom stimulants are not suitable, not tolerated, or shown to be ineffective. The …

cns stimulants
atomoxetine
gonadotropin
beta human chorionic gonadotrophin
human chorionic gonadotropin
Ninewells Hospital
 (0.8 away) Contact site
  • 359 views
  • 01 Feb, 2021
  • +73 other locations