Dundee, United Kingdom Clinical Trials

A listing of Dundee, United Kingdom clinical trials actively recruiting patients volunteers.

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Found 64 clinical trials
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the selected dose regimen in participants with metastatic or surgically unresectable urothelial cancers that harbor specific FGFR genomic alterations.

renal function
dose regimen
measurable disease
adjuvant chemotherapy
Ninewells Hospital
 (0.8 away) Contact site
  • 29 May, 2021
  • +150 other locations
Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis

A Multicentre, Randomised, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Efficacy and Safety Study of Tezepelumab in Participants with Severe Chronic Rhinosinusitis with Nasal Polyposis

Research Site
 (0.8 away) Contact site
  • 15 May, 2021
  • +96 other locations
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to …

Novo Nordisk Investigational Site
 (0.8 away) Contact site
  • 19 Jun, 2021
  • +242 other locations
Value of Inhaled Treatment With Aztreonam Lysine in Bronchiectasis

A randomised controlled trial of the safety, tolerability and effectiveness of 2 doses of Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis. Bronchiectasis not due to cystic fibrosis is a chronic inflammatory disease characterised by cough, sputum production and frequent respiratory tract infections. There are currently no licensed …

NHS Tayside
 (0.8 away) Contact site
  • 15 Feb, 2021
  • +5 other locations
Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR)

Patients with bronchiectasis (BE) suffer from a persistent cough, daily sputum expectoration, recurrent chest infections, and a poor health-related quality of life. Current guidelines for the management of BE highlight the lack of evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, to aid sputum-removal as part …

Royal Infirmary Edinburgh, NHS Lothian
 (36.0 away) Contact site
  • 23 Jan, 2021
  • +10 other locations
Single Palatal Temporary Anchorage Device for Anterior Open Bite

Participants are orthodontic patients with anterior open bite (AOB) malocclusion. These patients will be treated by molar intrusion achieved using one of two interventions, either orthodontic fixed appliances incorporating a single palatal Temporary Anchorage Device (TAD) or orthodontic fixed appliances incorporating two buccal TADs

Dundee Dental Hospital
 (0.4 away) Contact site
  • 02 May, 2021
  • 1 location
Study of Safety Tolerability Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in patients with bronchiectasis will demonstrate clinical safety and efficacy related to improved mucociliary clearance with reduced bacterial colonization as potential drivers of airway obstruction, reduced airway inflammation, exacerbations and mucus …

Novartis Investigative Site
 (0.8 away) Contact site
  • 19 Jun, 2021
  • +5 other locations
Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients

ICON 9 will assess the efficacy, safety and tolerability of maintenance olaparib in combination with cediranib compared to maintenance olaparib alone following a response to platinum-based chemotherapy in women with relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer. Prognostic and predictive factors will be studied from tumour and blood samples.

fallopian tube
platinum-based chemotherapy
ovarian epithelial carcinoma
endometrioid carcinoma
Ninewells Hospital
 (0.8 away) Contact site
  • 10 Jun, 2021
  • +44 other locations
A Study to Assess the Safety and Efficacy of Guanfacine Hydrochloride Prolonged Release (SPD503) in Children and Adolescents Aged 6 to 17 Years With Attentiondeficit/Hyperactivity Disorder (ADHD)

This interventional multicenter dose-optimization Phase IV PASS conducted in Europe and the USA evaluates the comparative long-term safety and efficacy of SPD503 in children and adolescents aged 6 to 17 years diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) for whom stimulants are not suitable, not tolerated, or shown to be ineffective. The …

human chorionic gonadotropin
attention deficit disorder
cns stimulants
psychiatric disorder
Ninewells Hospital
 (0.8 away) Contact site
  • 01 Feb, 2021
  • +73 other locations
Precision-Panc Master Protocol: Personalising Treatment for Pancreatic Cancer

The Precision-Panc Master Protocol is a "portal" protocol for patients with known or suspected pancreatic cancer to be accrued through multiple centres in the UK, with the option of being subsequently enrolled into PRIMUS (Pancreatic canceR Individualised Multi-arm Umbrella Studies) examining different treatment regimens and/or biomarker development. Eligible patients will …

pancreatic ductal adenocarcinoma
breast ductal carcinoma
cancer chemotherapy
Western General
 (36.0 away) Contact site
  • 26 Jan, 2021
  • +21 other locations