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  • Performance of a Fast-track Pathway for Giant Cell Arteritis Diagnosis

    Giant Cell Arteritis (GCA) or temporal arteritis is a systemic vasculitis (inflammation of the artery walls) that generally affects people over 50 years old, with a peak frequency between 70 and 80 years. The diagnosis is sometimes long and difficult to make due to non-specific clinical signs but must be rapid because of the risk of arterial occlusion that can lead to vision loss or stroke. Two GCA presentations can be detected : - an aortic form, i.e. inflammation of the aorta with specific clinical signs (abdominal pain, weight loss, ...) - a cephalic form with unusual headaches, jaw pain, scalp pain, shoulder and/or pelvic girdle pain, and inflammatory biological signs. The reference method for diagnosis has been based on clinical presumption. The presence of an inflammatory syndrome in biology and the analysis of a temporal artery biopsy. Since the mid-1990s, the improvement of ultrasound techniques, particularly with the appearance of high frequency probes, made it possible to detect inflammation of the temporal arteries in some cases. Each center published retrospective studies with the aim of avoiding biopsy but without really allowing the modification of clinical practices. A prospective multicenter study (doi: 10.7326/M23-3417) published in 2024 proved that in patients with high clinical probability of GCA, in case of bilateral positivity on temporal artery ultrasound (hypoechoic halo) it was not necessary to resort to a biopsy. When the ultrasound of bilateral arteries (particularly temporal and axillary) showed an abnormality such as a halo (inflammation), the diagnosis was made and did not require a biopsy. When the ultrasound was negative (or only present on one artery or another arterial axis), biopsy was necessary. In 50% of cases, the biopsy result was negative. Among these negative cases, a certain number were nevertheless retained as Giant Cell Arteritis, according to the clinician's assessment, and others were subjected to differential diagnoses. While with a biopsy the time to perform the procedure and obtain its interpretation was 10 days, ultrasound only requires one day to make a diagnosis. This study is at the origin of a change in diagnosing and treating patients with this Giant Cell Arteritis. In order to facilitate early diagnosis, a fast-track pathway has been set up based on the model published in 2024 (doi: 10.26635/6965.6376). The investigators propose to evaluate the performance of this fast-track clinic.

    Phase

    N/A

    Span

    111 weeks

    Sponsor

    Groupe Hospitalier de la Rochelle Ré Aunis

    La Rochelle

    Recruiting

  • Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

    Phase

    3

    Span

    249 weeks

    Sponsor

    AstraZeneca

    La Rochelle

    Recruiting

  • Telemonitoring Platform "CUREETY TECHCARE" vs Standard of Care for mTBNC Patients Initiating a First-line Treatment

    Phase

    N/A

    Span

    162 weeks

    Sponsor

    UNICANCER

    La Rochelle

    Recruiting

  • PROspective Master-protocol for Evaluation of Systemic THErapeutics in Elderly With Thoracic Malignancies

    Phase

    4

    Span

    205 weeks

    Sponsor

    Groupe Francais De Pneumo-Cancerologie

    La Rochelle

    Recruiting

  • Patient's Perspective on the Evolution of Hidradenitis Suppurativa Burden After Secukinumab Initiation

    This study is a prospective (primary data), national, descriptive, non-interventional, multicentre study conducted by medical practice and hospital-based dermatologists across different geographical regions in France. This real-world study does not change the physician-patient relationship or patient management or follow-up. Physicians remain free with their prescriptions and patient follow-up procedures. In fact, secukinumab initiation and all treatment decisions will be made according to routine medical care and independently of study participation. Recruited patients will be longitudinally followed-up for the duration of the study, up to 24 months (± 3 months) after secukinumab initiation or secukinumab treatment discontinuation before the end of the 24 months of follow-up (early discontinuation).

    Phase

    N/A

    Span

    146 weeks

    Sponsor

    Novartis Pharmaceuticals

    La Rochelle

    Recruiting

  • Long-term Evaluation of the SIMEOX Device at Home in Non-cystic Fibrosis Bronchiectasis

    Two main objectives will be assessed simultaneously: - To compare the effect of SIMEOX, combined with remote Physiotherapy, with enhanced SoC (SoC + Remote Physiotherapy), on the quality of life related to the respiratory problems of patients at mid term. - To compare the effect of SIMEOX, combined with remote Physiotherapy with enhanced SoC (SoC + Remote Physiotherapy) on the rate of respiratory exacerbations at long term.

    Phase

    N/A

    Span

    152 weeks

    Sponsor

    Physio-Assist

    La Rochelle

    Recruiting

  • Real-Life Use of Transabdominal Restorelle® Meshes in Apical Prolapse Repair

    This study is a non-interventional, multicenter and post market clinical follow-up in adult women with apical prolapse under normal conditions of use (after a sacrocolpopexy with Restorelle mesh for apical prolapse repair as part of routine care). The patient will be followed for 1 year (or less) by the investigator as per local usual practice. At the same time, the patient will be followed via PRO (Patient Reported Outcomes) over a period of 5 to 8 years.

    Phase

    N/A

    Span

    424 weeks

    Sponsor

    Coloplast A/S

    La Rochelle

    Recruiting

  • Evaluation of Security and Efficacy of Medtrum Hybrid Closed Loop System

    Phase

    N/A

    Span

    90 weeks

    Sponsor

    Medtrum France

    La Rochelle

    Recruiting

  • Patient-reported Outcome and Patient-reported Experience After Status Epilepticus

    Phase

    N/A

    Span

    114 weeks

    Sponsor

    Versailles Hospital

    La Rochelle

    Recruiting

  • Long-term Outcomes of Conduction System Pacing: a National Multicenter Observational Study - NORMAND'HIS / STIMU'HIS

    Phase

    N/A

    Span

    266 weeks

    Sponsor

    University Hospital, Rouen

    La Rochelle

    Recruiting

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