Observatory, South Africa Clinical Trials

A listing of Observatory, South Africa clinical trials actively recruiting patients volunteers.

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Found 147 clinical trials
Safety Tolerability and Efficacy of Rapid Optimization Helped by NT-proBNP testinG of Heart Failure Therapies

STRONG-HF is a multicenter, randomized, parallel group study designed to evaluate the efficacy and safety of up-titration of standard oral heart failure medications during hospitalization for acute heart failure. Patients admitted for acute heart failure will be randomized within 2 days before discharge to either usual care or intensification of …

dyspnea
potassium
angiotensin
beta-adrenergic blocking agents
acute heart failure
Tread Research
 (2.9 away) Contact site
  • 119 views
  • 18 Feb, 2021
  • +157 other locations
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

The aim of this study is to provide darolutamide treatment to patients who participated in a previous study with darolutamide supported by Bayer and the treating doctor considers that the continuation of the treatment with darolutamide to be beneficial. Patients will be carried over from the previous studies and continue …

Cancercare Rondebosch Oncology
 (2.0 away) Contact site
  • 0 views
  • 02 Jun, 2021
  • +251 other locations
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine …

Groote Schuur Hospital
 (0.2 away) Contact site
  • 0 views
  • 27 Jan, 2021
  • 1 location
A Trial to Evaluate the Efficacy and Safety of RSVpreF in Infants Born to Women Vaccinated During Pregnancy.

This randomized, double-blinded, placebo-controlled Phase 3 study is designed to evaluate the efficacy and safety of maternal immunization with RSVpreF against medically attended lower respiratory tract illness (MA-LRTI) in infants.

lower respiratory tract infection
vaccination
prenatal
FAMCRU, University of Stellenbosch, Paediatric
 (8.1 away) Contact site
  • 114 views
  • 03 Jun, 2021
  • +431 other locations
Etrasimod Versus Placebo as Induction Therapy in Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to assess the efficacy of etrasimod on clinical remission in participants with moderately to severely active ulcerative colitis (UC).

endoscopy
remission
Dr JP Wright Practice
 (3.6 away) Contact site
  • 12 views
  • 06 Jun, 2021
  • +414 other locations
Study of Safety Efficacy and Tolerability of Secukinumab Versus Placebo in Combination With SoC Therapy in Patients With Active Lupus Nephritis

The purpose of this trial is to evaluate the efficacy and safety of subcutaneous secukinumab 300 mg compared to placebo, in combination with standard of care therapy (SoC), in subjects with active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

urinary sediment
glomerular filtration rate
nephritis
mammogram
Novartis Investigative Site
 (7.2 away) Contact site
  • 37 views
  • 14 Jun, 2021
  • +107 other locations
A Phase II Randomized Double-blind Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis

This is a research study to determine the efficacy and safety of investigational drug MEDI3506 for the treatment of adult subjects with Chronic Obstructive Pulmonary Disease and Chronic Bonchitis.

Research Site
 (0.2 away) Contact site
  • 0 views
  • 12 May, 2021
  • +92 other locations
Study Evaluating Pharmacokinetics (PK) Safety and Efficacy of Cobicistat-boosted Atazanavir (ATV/co) or Cobicistat-boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in HIV-1 Infected Virologically Suppressed Pediatric Participants

Cohort 1: The primary objectives are: To evaluate the steady-state pharmacokinetics (PK) of Atazanavir (ATV) and Darunavir (DRV) and confirm the dose of Cobicistat-boosted Atazanavir (ATV/co) or Cobicistat-boosted Darunavir (DRV/co) in HIV-1 infected, virologically suppressed adolescent participants weighing 25 kg (12 to < 18 years of age) To evaluate the …

HIV Vaccine
atazanavir
antiretroviral
ritonavir
tenofovir
KIDCRU
 (2.9 away) Contact site
  • 236 views
  • 13 Jun, 2021
  • +40 other locations
Dolutegravir Study in HIV-1 Participants Completing IMPAACT Studies P1093 and P2019

Dolutegravir is a potent integrase strand transfer inhibitor. Abacavir/dolutegravir/lamivudine (ABC/DTG/3TC) is a fixed dose combination regimen containing two nucleoside reverse transcriptase inhibitors and dolutegravir. This is a phase 3b, non-randomized, open-label, multi-center, two treatment rollover study. The primary objective of this pediatric interventional study is to provide continued access to …

immunodeficiency
integrase inhibitors
reverse transcriptase inhibitor
dolutegravir
HIV Vaccine
GSK Investigational Site
 (9.0 away) Contact site
  • 188 views
  • 27 Jan, 2021
  • +14 other locations
Dolutegravir and Darunavir Evaluation in Adults Failing Therapy

DEFT is a randomised, open-label study in HIV-1 infected patients failing first-line antiretroviral therapy (ART). The study compares 2 regimens of second-line ART (dolutegravir and darunavir pharmaco-enhanced with ritonavir and dolutegravir and 2 prespecified NRTIs) with the WHO recommended regimen of 2NRTIs plus a ritonavir-boosted PI (Standard of Care (SOC)). …

reverse transcriptase inhibitor
dolutegravir
HIV Vaccine
antiretroviral
ritonavir
Desmond Tutu HIV Foundation
 (0.2 away) Contact site
  • 1172 views
  • 25 Mar, 2021
  • +31 other locations