Search Medical Condition
Please enter condition
Please choose location from dropdown

Observatory, South Africa Clinical Trials

A listing of Observatory, South Africa clinical trials actively recruiting patients volunteers.

RESULTS

Found (154) clinical trials

Secukinumab Safety and Efficacy in JPsA and ERA

This is a double-blind, placebo-controlled, event-driven randomized withdrawal study to investigate the efficacy and safety of secukinumab treatment in the Juvenile Idiopathic Arthritis (JIA) categories of Juvenile Psoriatic Arthritis (JPsA) and Enthesitis-related Arthritis (ERA). The study is divided into 3 parts (plus a post-treatment follow-up period) consisting of open-label, single-arm ...

Phase

0.23 miles

Learn More »

VATS ( Video-Assisted Thoracoscopy) Compared to Reinsertion of a Thoracostomy Tube for Persistent Haemothorax

This is a prospective, randomized study comparing VATS( Video-Assisted Thoracoscopy ) to reinsertion of a Thoracostomy Tube in patients with retained haemothorax. The hypothesis is that early VATS as opposed to reinsertion of a thoracostomy tube , will lead to less complications and shorter hospital stay.

Phase N/A

0.23 miles

Learn More »

Combating Craving With Contingency Management: Neuroplasticity and Methamphetamine Abuse in South Africa

Methamphetamine addiction (MA) is a global health problem with high prevalence and great social and health costs in the United States and in the Republic of South Africa, and there is a strong need for development and implementation of effective MA treatment approaches. This study will correlate MA-abstinence outcomes from ...

Phase N/A

0.23 miles

Learn More »

Cardiac REperfusion With Intralipid at Reperfusion

A single center randomised control study on cardiac protection with INTRALIPD in patients undergoing coronary artery bypass grafting on cardiopulmonary bypass. Purpose and objectives: Reperfusion after coronary artery bypass grafting is associated with a modifiable leak in cardiac Troponin I (cTnI) secondary to ischemia reperfusion injury. The purpose of the ...

Phase

0.23 miles

Learn More »

Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren

The investigators will conduct a n=5,400 Phase 3, double-blind, individually randomised placebo-controlled clinical trial of 5 years' duration in primary schools in City of Cape Town Metropolitan Municipality, Western Cape Province, Republic of South Africa. The primary objective of the trial is to determine whether a weekly oral dose of ...

Phase

0.23 miles

Learn More »

IMPI 2 - A Trial of Intrapericardial Alteplase in Large Pericardial Effusion

Intrapericardial fibrinolytic agents are used in the drainage of tuberculous, purulent, neoplastic and other inflammatory pericardial effusions to prevent recurrent effusions and constrictive pericarditis. This use is based on evidence from case reports and a small trial that did not have the statistical power to reliably evaluate the effect of ...

Phase

0.23 miles

Learn More »

Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers

The aim of the present study is to investigate changes in neural activity (BOLD signal), as measured using fMRI, in brain areas associated with emotional and working memory during task performance after single-dose administration of a novel selective alpha2c adrenoceptor antagonist (ORM-12741) in healthy volunteers. Further, it will be explored ...

Phase

0.23 miles

Learn More »

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent Adult and Elderly Hospitalized Participants With Influenza A Infection

This double-blind (neither researchers nor participants know what treatment participant is receiving) study will evaluate efficacy/safety of pimodivir in combination with SOC treatment versus placebo in combination with SOC treatment in adolescent, adult, and elderly hospitalized participants with influenza A infection. The study will be conducted in 3 phases: screening ...

Phase

0.23 miles

Learn More »

TMC125-TiDP35-C239 - Continued Access to Etravirine (ETR) in Treatment Experienced HIV-1 Infected Children and Adolescents

This is an open label continued access trial for HIV-1 infected children or adolescents who have completed treatment in a pediatric clinical trial with etravirine sponsored by or in collaboration with Janssen Research & Development and who continue to benefit from the use of etravirine. At the baseline visit, inclusion/exclusion ...

Phase

0.23 miles

Learn More »

Assessment of Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids

The primary objective of this study is to show superiority of vilaprisan in the treatment of heavy menstrual bleeding (HMB) in subjects with uterine fibroids compared to placebo.The secondary objectives of this study are to additionally evaluate the efficacy and safety of vilaprisan in subjects with uterine fibroids.

Phase

0.23 miles

Learn More »