Groenkloof, South Africa Clinical Trials

A listing of Groenkloof, South Africa clinical trials actively recruiting patients volunteers.

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Found 79 clinical trials
Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

RA is a chronic, systemic inflammatory autoimmune disease which requires treatment for a long time period, hence it is important to study the long-term safety and efficacy of the continuous treatment with GSK3196165 over several years. This is a Phase 3, multicenter, parallel group treatment and long-term extension study primarily …

rheumatic diseases
autoimmune disease
methotrexate
folate
folic acid
GSK Investigational Site
 (6.0 away) Contact site
  • 10 views
  • 27 Apr, 2021
  • +117 other locations
Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease

OSCAR (Otilimab in Severe COVID-19 Related Disease) is a multi-center, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of otilimab for the treatment of severe pulmonary COVID-19 related disease. The study is being conducted in 2 parts (Part 1 and Part 2). Otilimab is a human monoclonal anti-granulocyte …

coronavirus infection
mechanical ventilation
hypoxia
covid-19
x-rays
GSK Investigational Site
 (1.2 away) Contact site
  • 99 views
  • 01 May, 2021
  • +111 other locations
ACTIV-2: A Study for Outpatients With COVID-19

Drug studies often look at the effect one or two drugs have on a medical condition, and involve one company. There is currently an urgent need for one study to efficiently test multiple drugs from more than one company, in people who have tested positive for COVID-19 but who do …

SARS
nausea
covid-19
myalgia
dyspnea
Global Clinical Trials Sunnyside (Site 9216), 175 Steve Biko Street
 (1.9 away) Contact site
  • 104 views
  • 10 Jun, 2021
  • +210 other locations
A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults

This is a study to evaluate the effectiveness and safety of a coronavirus disease 2019 (COVID-19) vaccine called SARS-CoV-2 rS with Matrix-M1 adjuvant in a minimum of approximately 2,960 to a maximum of approximately 4,164 healthy HIV-negative (HIV-) adult participants and in approximately 240 medically stable HIV-positive (HIV+) adult participants …

Site ZA015
 (1.9 away) Contact site
  • 563 views
  • 26 Jan, 2021
  • +13 other locations
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

This study will assess the efficacy and safety of capivasertib plus abiraterone (+prednisone/prednisolone) plus androgen deprivation therapy (ADT) versus placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC whose tumours are characterised by PTEN deficiency. The intention of the study is to demonstrate that in participants with mHSPC, the …

Research Site
 (2.2 away) Contact site
  • 109 views
  • 13 Jun, 2021
  • +263 other locations
Study to Describe the Safety Tolerability Immunogenicity and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals

This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. The study will evaluate the safety, tolerability, and immunogenicity …

SARS
covid-19
Jongaie Research
 (5.8 away) Contact site
  • 24080 views
  • 07 Jun, 2021
  • +196 other locations
Pivotal Study to Assess the Efficacy Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by Annualized rate of acute moderate or severe COPD exacerbation (AECOPD) Secondary Objectives: To evaluate the effect of dupilumab administered every 2 weeks on Pre-bronchodilator …

forced expiratory volume
bronchitis
corticosteroids
severe chronic obstructive pulmonary disease
dyspnea
Investigational Site Number 7100005
 (5.7 away) Contact site
  • 156 views
  • 13 Jun, 2021
  • +202 other locations
Darolutamide in Addition to ADT Versus ADT in Metastatic Hormone-sensitive Prostate Cancer

The purpose of the study is to assess the efficacy and safety of darolutamide in combination with standard androgen deprivation therapy (ADT) in patients with metastatic hormone sensitive prostate cancer.

University of Pretoria, Clinical Research Unit
 (2.5 away) Contact site
  • 0 views
  • 08 Jun, 2021
  • +143 other locations
Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants

The trial is designed as a phase III, double-blind, multicenter, randomized, single administration, active-controlled, parallel-group design with two groups of newborn infants receiving either VPM1002 or BCG SII (1:1 allocation) to assess the efficacy, safety and immunogenicity of VPM1002 against Mtb infection.

MeCRU clinical research Unit
 (7.2 away) Contact site
  • 0 views
  • 16 Feb, 2021
  • +9 other locations
CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients

This is a phase 3, randomized, placebo controlled, double-blind, multicenter, stratified study of CPI-006 plus standard of care (SOC) versus placebo plus SOC in mild to moderately symptomatic hospitalized Covid-19 patients with the primary objective to compare the proportion of participants alive and respiratory failure free between CPI-006 plus SOC …

Global Clinical Trials Sunnyside
 (1.9 away) Contact site
  • 0 views
  • 15 Jun, 2021
  • +115 other locations