Groenkloof, South Africa Clinical Trials

A listing of Groenkloof, South Africa clinical trials actively recruiting patients volunteers.

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Found 78 clinical trials
Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

RA is a chronic, systemic inflammatory autoimmune disease which requires treatment for a long time period, hence it is important to study the long-term safety and efficacy of the continuous treatment with GSK3196165 over several years. This is a Phase 3, multicenter, parallel group treatment and long-term extension study primarily …

folic acid
rheumatic diseases
autoimmune disease
GSK Investigational Site
 (6.0 away) Contact site
  • 27 Apr, 2021
  • +117 other locations
Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease

OSCAR (Otilimab in Severe COVID-19 Related Disease) is a multi-center, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of otilimab for the treatment of severe pulmonary COVID-19 related disease. The study is being conducted in 2 parts (Part 1 and Part 2). Otilimab is a human monoclonal anti-granulocyte …

mechanical ventilation
coronavirus infection
GSK Investigational Site
 (1.2 away) Contact site
  • 01 May, 2021
  • +111 other locations
Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

The purpose of this study is to assess the efficacy and safety of treatment with carboplatin/paclitaxel* PLUS pembrolizumab (MK-3475) and maintenance olaparib (MK-7339) in women with epithelial ovarian cancer (EOC), fallopian tube cancer, or primary peritoneal cancer. The primary study hypotheses are that the combination of pembrolizumab plus carboplatin/paclitaxel* followed …

debulking surgery
solid tumour
primary debulking surgery
tumor debulking
Department of Medical Oncology ( Site 1703)
 (2.5 away) Contact site
  • 14 Jun, 2021
  • +258 other locations
Pivotal Study to Assess the Efficacy Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by Annualized rate of acute moderate or severe COPD exacerbation (AECOPD) Secondary Objectives: To evaluate the effect of dupilumab administered every 2 weeks on Pre-bronchodilator …

severe chronic obstructive pulmonary disease
forced expiratory volume
muscarinic antagonists
Investigational Site Number 7100005
 (5.7 away) Contact site
  • 13 Jun, 2021
  • +202 other locations
A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will …

Novo Nordisk Investigational Site
 (5.4 away) Contact site
  • 13 Jun, 2021
  • +71 other locations
Sisonke (Together): OPEN LABEL TRIAL COVID-19

To monitor the effectiveness of the single-dose Ad26.COV2.S COVID-19 vaccine among health care workers (HCW) in South Africa

Ndlovu Research Centre
 (1.9 away) Contact site
  • 29 Apr, 2021
  • +30 other locations
A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults

This is a study to evaluate the effectiveness and safety of a coronavirus disease 2019 (COVID-19) vaccine called SARS-CoV-2 rS with Matrix-M1 adjuvant in a minimum of approximately 2,960 to a maximum of approximately 4,164 healthy HIV-negative (HIV-) adult participants and in approximately 240 medically stable HIV-positive (HIV+) adult participants …

Site ZA015
 (1.9 away) Contact site
  • 26 Jan, 2021
  • +13 other locations
ACTIV-2: A Study for Outpatients With COVID-19

Drug studies often look at the effect one or two drugs have on a medical condition, and involve one company. There is currently an urgent need for one study to efficiently test multiple drugs from more than one company, in people who have tested positive for COVID-19 but who do …

Global Clinical Trials Sunnyside (Site 9216), 175 Steve Biko Street
 (1.9 away) Contact site
  • 10 Jun, 2021
  • +210 other locations
Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma

Study D9181C00001 is a Phase II, randomised, double-blind, placebo-controlled, parallel group, proof of concept study to evaluate the efficacy, safety, pharmacokinetics (PK) and immunogenicity of MEDI3506 in adult participants with uncontrolled moderate to severe asthma on standard of care (SOC). Up to approximately 80 sites globally will participate in this …

Research Site
 (2.5 away) Contact site
  • 04 Jun, 2021
  • +71 other locations
CROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION

The objective of CROWN CORONATION is the prevention of symptomatic COVID-19 by using combinations of approved and safe repurposed interventions, with complementary mechanisms of action.

coronavirus infection
Steve Biko Academic Hospital
 (2.8 away) Contact site
  • 20 May, 2021
  • +26 other locations