Groenkloof, South Africa Clinical Trials

A listing of Groenkloof, South Africa clinical trials actively recruiting patients volunteers.

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Found 78 clinical trials
Pivotal Study to Assess the Efficacy Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by Annualized rate of acute moderate or severe COPD exacerbation (AECOPD) Secondary Objectives: To evaluate the effect of dupilumab administered every 2 weeks on Pre-bronchodilator …

pulmonary function test
copd exacerbation
bronchodilator
cough
dyspnea
Investigational Site Number 7100005
 (5.7 away) Contact site
  • 156 views
  • 13 Jun, 2021
  • +202 other locations
A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will …

Novo Nordisk Investigational Site
 (5.4 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +71 other locations
Sisonke (Together): OPEN LABEL TRIAL COVID-19

To monitor the effectiveness of the single-dose Ad26.COV2.S COVID-19 vaccine among health care workers (HCW) in South Africa

Ndlovu Research Centre
 (1.9 away) Contact site
  • 0 views
  • 29 Apr, 2021
  • +30 other locations
A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults

This is a study to evaluate the effectiveness and safety of a coronavirus disease 2019 (COVID-19) vaccine called SARS-CoV-2 rS with Matrix-M1 adjuvant in a minimum of approximately 2,960 to a maximum of approximately 4,164 healthy HIV-negative (HIV-) adult participants and in approximately 240 medically stable HIV-positive (HIV+) adult participants …

Site ZA015
 (1.9 away) Contact site
  • 563 views
  • 26 Jan, 2021
  • +13 other locations
ACTIV-2: A Study for Outpatients With COVID-19

Drug studies often look at the effect one or two drugs have on a medical condition, and involve one company. There is currently an urgent need for one study to efficiently test multiple drugs from more than one company, in people who have tested positive for COVID-19 but who do …

rhinorrhea
pharyngitis
SARS
fever
cough
Global Clinical Trials Sunnyside (Site 9216), 175 Steve Biko Street
 (1.9 away) Contact site
  • 104 views
  • 10 Jun, 2021
  • +210 other locations
Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma

Study D9181C00001 is a Phase II, randomised, double-blind, placebo-controlled, parallel group, proof of concept study to evaluate the efficacy, safety, pharmacokinetics (PK) and immunogenicity of MEDI3506 in adult participants with uncontrolled moderate to severe asthma on standard of care (SOC). Up to approximately 80 sites globally will participate in this …

Research Site
 (2.5 away) Contact site
  • 218 views
  • 04 Jun, 2021
  • +71 other locations
CROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION

The objective of CROWN CORONATION is the prevention of symptomatic COVID-19 by using combinations of approved and safe repurposed interventions, with complementary mechanisms of action.

coronavirus infection
Steve Biko Academic Hospital
 (2.8 away) Contact site
  • 332 views
  • 20 May, 2021
  • +26 other locations
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

This study will assess the efficacy and safety of capivasertib plus abiraterone (+prednisone/prednisolone) plus androgen deprivation therapy (ADT) versus placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC whose tumours are characterised by PTEN deficiency. The intention of the study is to demonstrate that in participants with mHSPC, the …

Research Site
 (2.2 away) Contact site
  • 109 views
  • 13 Jun, 2021
  • +263 other locations
Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)

The purpose of this study is to assess the efficacy and safety of treatment with olaparib (MK-7339) in combination with pembrolizumab (MK-3475) in adults with previously treated, advanced (metastatic and/or unresectable) Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-positive solid tumors.

cancer of the ovary
cancer
mk-3475
solid tumor
measurable disease
Mary Potter Oncology Centre, Little Company of Mary Hospital ( Site 1900)
 (4.0 away) Contact site
  • 16 views
  • 13 Jun, 2021
  • +144 other locations
Efficacy and Safety of MK-1654 in Infants (MK-1654-004)

The primary objectives of this phase 2b/3 double-blind, randomized, placebo-controlled study are to evaluate the efficacy and safety of MK-1654 in healthy pre-term and full-term infants. It is hypothesized that MK-1654 will reduce the incidence of respiratory syncytial virus (RSV)-associated medically attended lower respiratory infection (MALRI) from Days 1 through …

Steve Biko Academic Hospital ( Site 2505)
 (2.5 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +18 other locations