Groenkloof, South Africa Clinical Trials

A listing of Groenkloof, South Africa clinical trials actively recruiting patients volunteers.

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Found 81 clinical trials
Efficacy Safety and Tolerability of V937 Administered Intravenously or Intratumorally With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone in Participants With Advanced/Metastatic Melanoma (V937-011)

This is a Phase 2 study to assess the efficacy, safety, and tolerability of V937 administered both intratumorally (ITu) and intravenously (IV) as combination therapy with pembrolizumab (MK-3475) versus pembrolizumab alone in anti-programmed cell death ligand 1 (anti-PD-L1)-treatment-naive participants with advanced/metastatic melanoma. The primary hypothesis of the study is that …

Clinical Research Unit - University of Pretoria ( Site 0102)
 (2.5 away) Contact site
  • 3 views
  • 17 Jun, 2021
  • +26 other locations
Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-angle Glaucoma or Ocular Hypertension

This study evaluates the duration of intraocular pressure (IOP)-lowering effect and safety of as needed administrations of Bimatoprost sustained release (SR) in participants with open-angle glaucoma (OAG) or ocular hypertension (OHT) who are not adequately managed with topical IOP-lowering medication for reasons other than medication efficacy.

brimonidine tartrate ophthalmic solution
glaucoma
hypertension
bimatoprost
intraocular pressure
Pretoria Eye Institute
 (1.9 away) Contact site
  • 202 views
  • 14 May, 2021
  • +109 other locations
A Comparative Study Between PF-06410293 and Humira in Combination With Methotrexate in Participants With Active Rheumatoid Arthritis

The study will assess the impact of pharmacokinetics (PK), safety and immunogenicity after switches between PF-06410293 and adalimumab and with continuous dosing with adalimumab in combination with methotrexate in subjects with moderately to severely active rheumatoid arthritis.

humira
methotrexate
adalimumab
Emmed Research
 (2.5 away) Contact site
  • 124 views
  • 17 Jun, 2021
  • +77 other locations
A Study to Assess EDP-938 for the Treatment of Acute Upper Respiratory Tract Infection With Respiratory Syncytial Virus in Adult Subjects

This is a randomized, double-blind, placebo-controlled, multicentre, phase 2 study to evaluate the efficacy, safety and tolerability of orally administered EDP-938 in adults with RSV infection.

nasal congestion
earache
malaise
wheezing
dyspnea
Setshaba Research Centre
 (7.8 away) Contact site
  • 99 views
  • 19 Jun, 2021
  • +109 other locations
Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine in Healthy Adults Adolescents and Children in India and Healthy Adolescents and Children in the Republic of South Africa

The primary objective of this study is to demonstrate the non-inferiority of immunogenicity of a single dose of MenACYW conjugate vaccine compared to Menactra in adolescents and children aged 2 to 17 years in terms of serum bactericidal assay using human complement (hSBA) titers. The secondary objectives of the study …

Investigational Site Number 7100006
 (2.5 away) Contact site
  • 86 views
  • 16 Jun, 2021
  • +10 other locations
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC

Phase III Study of Capivasertib + Paclitaxel versus Placebo + Paclitaxel as First line Treatment for Patients with Locally Advanced or Metastatic Triple-negative Breast Cancer (TNBC)

mammogram
paclitaxel
formalin-fixed paraffin-embedded
breast cancer
triple-negative breast cancer
Research Site
 (3.5 away) Contact site
  • 1387 views
  • 21 Apr, 2021
  • +307 other locations
Etrasimod Versus Placebo as Induction Therapy in Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to assess the efficacy of etrasimod on clinical remission in participants with moderately to severely active ulcerative colitis (UC).

endoscopy
remission
Johese Clinical Research: Unitas
 (3.1 away) Contact site
  • 12 views
  • 06 Jun, 2021
  • +414 other locations
Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation

Interventional, randomized, double-blind, placebo-controlled study encompassing 2 development phases (Phase 2 and Phase 3).

mechanical ventilation
pneumonia
fever
chest x-ray
SARS
Into Research - Little Company of Mary Medical Center
 (4.0 away) Contact site
  • 122 views
  • 17 Mar, 2021
  • +32 other locations
A Study to Assess the Efficacy and Safety of Budesonide/Albuterol Metered-dose Inhaler (BDA MDI/PT027) in Adults and Children 4 Years of Age or Older With Asthma

This is a randomized, double-blind, multicenter, parallel-group, variable-length study to compare 2 doses of BDA MDI (PT027) with AS MDI (PT007) on the time to first severe asthma exacerbation in adult, adolescent, and pediatric subjects with moderate to severe asthma.

theophylline
budesonide
albuterol
muscarinic antagonists
spirometry
Research Site
 (1.9 away) Contact site
  • 2319 views
  • 12 Mar, 2021
  • +280 other locations
Study to Describe the Safety Tolerability Immunogenicity and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals

This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. The study will evaluate the safety, tolerability, and immunogenicity …

SARS
covid-19
Jongaie Research
 (5.8 away) Contact site
  • 24080 views
  • 07 Jun, 2021
  • +196 other locations