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Loshkar-ola, Russian Federation

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  • Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia

    This study will utilize a randomized, double-blind, placebo-controlled experimental approach to determine the effects of 8-wk treatment with Suvorexant (Belsomra®) on sympathetic nerve activity and baroreflex function in male and female subjects with chronic insomnia. The study will utilize established techniques for assessing sleep (polysomnography), blood pressure (sphygmomanometer and beat-to-beat finger plethysmography), and peripheral sympathetic nerve activity (microneurography). The study will stratify enrollment based upon both age and sex (i.e., male vs. female) because these two covariates are known to influence sympathetic nerve activity and baroreflex function.

    Phase

    4

    Span

    211 weeks

    Sponsor

    Montana State University

    Houghton, Michigan

    Recruiting

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