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  • Research of the Consequences on the Digestive Tract Following the Proposed Treatments for a Urinary Infection in Children

    Phase

    N/A

    Span

    315 weeks

    Sponsor

    Centre Hospitalier Intercommunal Creteil

    Charenton-le-Pont

    Recruiting

  • A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

    Phase

    3

    Span

    255 weeks

    Sponsor

    Dizal Pharmaceuticals

    Saint-Mande

    Recruiting

  • Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus

    The RODEO 1 study is designed to determine the safety and efficacy of partial oral treatment of IE compared with traditional full-length parenteral treatment. Our primary objective is to demonstrate that in patients with left-sided multi-susceptible Staphylococcus who have received at least 10 days of IV antibiotic treatment with or without valvular surgery, a switch to an oral combination of rifampicin and fluoroquinolones between Day 10 and Day 28 after initiation of the IV antibiotic treatment, is not inferior to the continuation of the conventional IV antibiotic treatment regarding to treatment failure within 3 months after the end of antibiotic treatment. Nationwide, noninferiority, multicenter, randomized, controlled, open-label trials. Randomisation will only be offered to patients who have received at least 10 days of IV conventional antibiotic treatment of IE, and fulfil the inclusion criteria. Randomisation will take place between Day 10 and Day 28 after initiation of parenteral antibiotic therapy or valvular surgery, thus ensuring to have at least 14 days of oral therapy in the experimental group. Patients will be eligible whether they have undergone valvular surgery or not. This will imply that surgery procedure prior to randomisation will be heterogeneous, but randomisation will be stratified on the requirement of valvular surgery as part of the treatment of the current episode of IE or not.

    Phase

    3

    Span

    448 weeks

    Sponsor

    University Hospital, Tours

    Saint-Mande

    Recruiting

  • Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus

    The RODEO 2 study is designed to determine the safety and efficacy of partial oral treatment of IE compared with traditional full-length parenteral treatment. Our primary objective is to demonstrate that in patients with left-sided multi-susceptible Streptococcus-Enterococcus IE who have received at least 10 days of IV antibiotic treatment with or without valvular surgery, a switch to an oral combination of amoxicillin between Day 10 and Day 28 after initiation of the IV antibiotic treatment, is not inferior to the continuation of the conventional IV antibiotic treatment regarding to treatment failure within 3 months after the end of antibiotic treatment. Nationwide, noninferiority, multicenter, randomized, controlled, open-label trials. Randomisation will only be offered to patients who have received at least 10 days of IV conventional antibiotic treatment of IE, and fulfil the inclusion criteria. Randomisation will take place between Day 10 and Day 28 after initiation of parenteral antibiotic therapy or valvular surgery, thus ensuring to have at least 14 days of oral therapy in the experimental group. Patients will be eligible whether they have undergone valvular surgery or not. This will imply that surgery procedure prior to randomisation will be heterogeneous, but randomisation will be stratified on the requirement of valvular surgery as part of the treatment of the current episode of IE or not.

    Phase

    3

    Span

    448 weeks

    Sponsor

    University Hospital, Tours

    Saint-Mande

    Recruiting

  • A Study to Learn About Abrocitinib in Adult Patients With Moderate to Severe Atopic Dermatitis.

    Phase

    N/A

    Span

    221 weeks

    Sponsor

    Pfizer

    Saint-Mande

    Recruiting

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