Heeze, Netherlands Clinical Trials

A listing of Heeze, Netherlands clinical trials actively recruiting patients volunteers.

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Found 121 clinical trials
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate AS as compared with OHFT.

transcatheter aortic valve implantation
stenosis
aortic valve replacement
dobutamine
stress echocardiography
Catharina Ziekenhuis
 (6.2 away) Contact site
  • 0 views
  • 24 Jan, 2021
  • +47 other locations
Triple-B Study;Carboplatin-cyclophosphamide Versus Paclitaxel With or Without Atezolizumab as First-line Treatment in Advanced Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is a difficult to treat molecular subtype with a poor survival. TNBC can be divided into at least two molecular entities; BRCA-like and non-BRCA-like. In this trial we would like to investigate whether a molecular subgroup exists within TNBCs that derives a benefit from atezolizumab …

measurable disease
chromogenic in situ hybridization
tumor cells
paclitaxel
cyclophosphamide
Catharina ziekenhuis
 (6.2 away) Contact site
  • 36 views
  • 24 Jun, 2021
  • +49 other locations
Multicentric Randomised Trial for Resectable Gastric Cancer

The CRITICS-II trial aims to identify the optimal preoperative regimen in resectable gastric cancer by comparing three investigational treatment arms: chemotherapy vs. chemotherapy and subsequent chemoradiotherapy vs. chemoradiotherapy. The rationale behind this trial design is based on the following concepts: Preoperative treatment is associated with better patient compliance than postoperative …

oxaliplatin
adenocarcinoma
cancer chemotherapy
gastrectomy
carboplatin
St. Anna Zorggroep
 (2.7 away) Contact site
  • 6 views
  • 30 Jan, 2021
  • +28 other locations
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in …

adenocarcinoma
dysplasia
body mass index (bmi)
reflux
proton pump inhibitors
Lucid Investigative Site
 (7.3 away) Contact site
  • 256 views
  • 28 Jul, 2021
  • +36 other locations
Nivolumab Ipilimumab and COX2-inhibition in Early Stage Colon Cancer: an Unbiased Approach for Signals of Sensitivity

In this exploratory study, patients with stage 1-3 adenocarcinoma of the colon with no signs of distant metastases will be treated with short-term immunotherapy + COX2-inhibitors. This treatment will be given during the window period until surgical resection of the tumor. The duration of treatment will be approximately 6 weeks.

Catharina Ziekenhuis
 (7.3 away) Contact site
  • 28 views
  • 28 Apr, 2021
  • +7 other locations
ENdometrial Cancer SURvivors' Follow-up carE (ENSURE): Less is More?

Background: It has often been hypothesized that the frequency of follow-up for patients with early-stage endometrial cancer could be decreased. However, studies evaluating effects of a reduced follow-up schedule among this patient group are lacking. Objective: Assess patient satisfaction and cost-effectiveness of a less frequent follow-up schedule compared to the …

cancer
carcinoma
endometrial carcinoma
Catharina Hospital
 (6.2 away) Contact site
  • 69 views
  • 23 Jan, 2021
  • +46 other locations
Elderly With Locally Advanced Lung Cancer: Deciding Through Geriatric Assessment on the Optimal Treatment Strategy

There is no detailed information available on benefits and harms of intensified treatment with concurrent RCHT among a subpopulation of elderly patients. Reliable tools are needed to distinguish the subgroup of fit patients from frail patients.

advanced lung cancer
lung carcinoma
Catharina Hospital Eindhoven
 (7.3 away) Contact site
  • 10 views
  • 23 Jan, 2021
  • +17 other locations
Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children

OBJECTIVE The aim of this study is to compare the effectiveness of initial non-operative treatment strategy (reserving appendectomy for those not responding or with recurrent disease) with immediate appendectomy in children from 7 to 17 years old, inclusive, with acute simple appendicitis in terms of complications, health-related QOL and costs. …

appendectomy
abscess
antibiotics
phlegmon
amoxicillin
Maxima medical center
 (6.2 away) Contact site
  • 90 views
  • 25 Jan, 2021
  • +13 other locations
Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases

This is a multicentre, open-label, parallel-group, phase II-III, superiority study that randomises patients with isolated resectable colorectal peritoneal metastases in a 1:1 ratio to receive either perioperative systemic therapy and cytoreductive surgery with HIPEC (experimental arm) or upfront cytoreductive surgery with HIPEC alone (control arm).

hyperthermic intraperitoneal chemotherapy
measurable disease
laparoscopy
folfiri regimen
peritoneal metastases
Catharina Hospital
 (6.2 away) Contact site
  • 76 views
  • 22 Jan, 2021
  • +9 other locations
Chemotherapy and Maximal Tumor Debulking of Multi-organ Colorectal Cancer Metastases

The purpose of this study is to compare overall survival rates of colorectal cancer patients with multi-organ metastases with an indication for first line systemic treatment randomized for treatment with combination chemotherapy or treatment with combination chemotherapy and additional maximal tumor debulking including surgical tumor resection, RFA, (DEBIRI-)TACE and SBRT, …

Maxima Medisch Centrum
 (6.2 away) Contact site
  • 22 views
  • 03 Jul, 2021
  • +29 other locations