Heeze, Netherlands Clinical Trials

A listing of Heeze, Netherlands clinical trials actively recruiting patients volunteers.

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Found 8 clinical trials
Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)

The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and enzalutamide in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC, are abiraterone-nave, or are intolerant to or progressed on abiraterone acetate. There …

tumor progression
diphosphonates
bisphosphonate
testosterone
ct scan
Catharina Ziekenhuis ( Site 0472)
 (7.3 away) Contact site
  • 487 views
  • 20 Jun, 2021
  • +241 other locations
A Study of Apalutamide in Participants With High-Risk Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy (RP) with pelvic lymph node dissection (pLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and …

metastasis
apalutamide
androgen suppression
prostatectomy
adenocarcinoma of prostate
Catharinaziekenhuis
 (7.3 away) Contact site
  • 291 views
  • 02 Jun, 2021
  • +352 other locations
The Impact of a Nutritional Supplement (Impryl ) on Male Fertility

Infertility is a worldwide problem and about 10%-15% of all couples will be affected by the inability to have children. In approximately 50% of infertile couples a male factor is involved. Male infertility is of multifactorial origin. In the past decade, the role of oxidative stress on sperm has been …

M xima Medisch Centrum
 (6.9 away) Contact site
  • 418 views
  • 24 Jan, 2021
  • +17 other locations
PSMA-PET Guided Hypofractionated Salvage Prostate Bed Radiotherapy

After radical prostatectomy approximately 15-40% of men develop a biochemical recurrence (BR) within 5 years. The standard treatment of post-prostatectomy BR is salvage external beam radiation therapy (sEBRT). sEBRT can provide long-term disease control; with 5 year biochemical progression-free survival (bPFS) up to 60% and with most treatment failures in …

Catharina-Hospital
 (6.2 away) Contact site
  • 0 views
  • 12 Jun, 2021
  • +11 other locations
Self-testing for HCV Re-infection in MSM

HIV+MSM (men who have sex with men) that have been cured of a hepatitis C viral infection (HCV) are at risk for HCV re-infection (5-10% per year). One intervention to reduce HCV incidence in this population may be to decrease the time to diagnosis of HCV re-infections in order to …

Catharina Ziekenhuis Eindhoven
 (6.2 away) Contact site
  • 17 views
  • 23 Jan, 2021
  • +6 other locations
Androgen Deprivation Therapy for Oligo-recurrent Prostate Cancer in Addition to radioTherapy

The overall aim of this project is to test the hypothesis that the addition of ADT to metastasis-directed radiotherapy (MDRT) in well-selected PCa patients with oligo-metastatic disease prolongs the metastases progression-free survival (MPFS) compared to MDRT alone.

recurrent prostate cancer
prostate specific antigen
metastasis
ct scan
androgen suppression
Catharina Hospital
 (6.2 away) Contact site
  • 0 views
  • 15 Jun, 2021
  • +12 other locations
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in …

reflux
esophageal adenocarcinoma
gastroesophageal reflux
esophagogastroduodenoscopy
intramucosal adenocarcinoma
Lucid Investigative Site
 (7.3 away) Contact site
  • 256 views
  • 16 Apr, 2021
  • +34 other locations
The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A and B

There are large inter-individual differences in the bleeding pattern of patients with moderate or mild hemophilia. The major determinant of bleeding phenotype is the level of coagulant factor VIII or IX. In hemophilia A, studies addressing the association between factor VIII level and the clinical bleeding pattern yield conflicting results. …

coagulant
christmas disease
antihemophilic factor
factor ix
plasma factor viii level
M xima Medical Center
 (7.7 away) Contact site
  • 67 views
  • 22 Jan, 2021
  • +11 other locations