Heeze, Netherlands Clinical Trials

A listing of Heeze, Netherlands clinical trials actively recruiting patients volunteers.

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Found 13 clinical trials
Endocrine Therapy Plus CDK4/6 in First or Second Line for Hormone (SONIA) Receptor Positive Advanced Breast Cancer

Given the uncertain benefit in efficacy of adding CDK 4/6 to first rather than second line endocrine treatment, the aim of this project is to evaluate whether the sequence of an aromatase inhibitor plus CDK 4/6 in first line followed by fulvestrant in second line is superior to the sequence …

adenocarcinoma
metastasis
liver metastases
aromatase inhibitor
gilbert's syndrome
St. Anna Ziekenhuis
 (3.0 away) Contact site
  • 71 views
  • 19 Jan, 2020
  • +71 other locations
Tailoring NEOadjuvant Therapy in Hormone Receptor Positive HER2 Negative Luminal Breast Cancer.

The aim of this prospective, randomized, multicenter, open-label, phase II study is to test if chemotherapy can be replaced by the combination of ribociclib plus letrozole as a neo-adjuvant therapy for patients with non-metastatic primary luminal breast cancer.

letrozole
core needle biopsy
breast cancer
ki-67
cancer
Catharina Ziekenhuis
 (6.2 away) Contact site
  • 97 views
  • 19 Jan, 2020
  • +29 other locations
ENdometrial Cancer SURvivors' Follow-up carE (ENSURE): Less is More?

Background: It has often been hypothesized that the frequency of follow-up for patients with early-stage endometrial cancer could be decreased. However, studies evaluating effects of a reduced follow-up schedule among this patient group are lacking. Objective: Assess patient satisfaction and cost-effectiveness of a less frequent follow-up schedule compared to the …

cancer
carcinoma
endometrial carcinoma
Catharina Hospital
 (6.2 away) Contact site
  • 69 views
  • 12 Aug, 2019
  • +45 other locations
PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer

This is prospective, multicenter, randomised phase III trial among women with endometrial cancer with high-intermediate risk features to investigate the role of an integrated clinicopathological and molecular risk profile to determine if participants should receive no adjuvant therapy, vaginal brachytherapy or external beam radiotherapy based on a favourable, intermediate or …

Catharina Hospital
 (6.2 away) Contact site
  • 72 views
  • 17 Feb, 2020
  • +24 other locations
RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)

Purpose of this prospective, randomized, controlled, multi-center study is to evaluate the safety and efficacy of Transcatheter Aortic Valve Implantation (TAVI) as compared to surgical aortic valve replacement (SAVR) in female patients with severe symptomatic aortic stenosis. Patients will be randomized 1:1 to receive either TAVI or SAVR aortic valve …

calcium
stenosis
transcatheter aortic valve implantation
tavi
dobutamine
Catharina Ziekenhuis Eindhoven
 (7.3 away) Contact site
  • 94 views
  • 18 Nov, 2020
  • +35 other locations
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.

fallopian tube
cancer
ovarian cancer
rad51c
oophorectomy
Catharina Ziekenhuis
 (7.3 away) Contact site
  • 0 views
  • 11 Jun, 2020
  • +1 other locations
A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer

Endometrial cancer accounts for greater than 90 percent (%) of all uterine cancer. The majority of participants with endometrial cancer are diagnosed in early stages (Stage I or II) and receive surgery with curative intent; however, approximately 20% are diagnosed with advanced or metastatic disease (Stage III or IV) for …

direct bilirubin
carcinosarcoma
anticoagulants
recurrent disease
carboplatin/paclitaxel
GSK Investigational Site
 (7.3 away) Contact site
  • 78 views
  • 19 Nov, 2020
  • +138 other locations
Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy

This is a randomized-controlled open-label trial comparing two different doses of low-molecular-weight heparin (LMWH) in pregnant patients with a history of previous venous thromboembolism (VTE). Both doses are recommended doses in the 2012 guidelines of the American College of Chest Physicians (ACCP), but it is not known which dose is …

tinzaparin
nadroparin
enoxaparin
venous thromboembolism
dalteparin
M xima MC
 (7.7 away) Contact site
  • 263 views
  • 08 Jul, 2019
  • +73 other locations
Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers

The purpose of this study is to determine whether an innovative preventive strategy, consisting of early salpingectomy upon completion of childbearing with delayed oophorectomy beyond current guideline age, improves menopause-related quality of life without significantly increasing ovarian cancer incidence in comparison to current standard salpingo-oophorectomy in female BRCA1/2 mutation carriers.

BRCA1/2
BRCA1
cancer of the ovary
ovarian cancer
oophorectomy
Catharina Hospital
 (7.3 away) Contact site
  • 56 views
  • 08 Nov, 2020
  • +12 other locations
Sexual Rehabilitation Programme After Radiotherapy for Gynaecological Cancer

The aim of this randomized controlled trial is to demonstrate that a nurse-led sexual rehabilitation intervention significantly improves sexual recovery and functioning among gynaecological cancer (GC) patients treated with radiotherapy (RT), compared with usual care (i.e., oral information by a nurse or doctor and written information). Women with GC (n=220) …

cancer
Catharina Hospital
 (6.2 away) Contact site
  • 12 views
  • 02 Mar, 2020
  • +7 other locations