Enschede, Netherlands Clinical Trials

A listing of Enschede, Netherlands clinical trials actively recruiting patients volunteers.

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Found 62 clinical trials
Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease

OSCAR (Otilimab in Severe COVID-19 Related Disease) is a multi-center, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of otilimab for the treatment of severe pulmonary COVID-19 related disease. The study is being conducted in 2 parts (Part 1 and Part 2). Otilimab is a human monoclonal anti-granulocyte …

pneumonia
hypoxia
coronavirus infection
x-rays
glucose
GSK Investigational Site
 (0.3 away) Contact site
  • 99 views
  • 01 May, 2021
  • +111 other locations
ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.

Aim of the ACTION-1 study is to determine whether ACT guided heparinization decreases thrombo-embolic complications (TEC) and mortality after elective open AAA surgery, without causing more bleeding complications.

heparin
open repair
aortic aneurysm
aneurysm repair
aaa surgery
Medisch Spectrum Twente
 (0.3 away) Contact site
  • 10 views
  • 13 May, 2021
  • +19 other locations
Randomized Controlled Study of IFX-1 in Patients With Severe COVID-19 Pneumonia

Phase II & Phase III: This is a pragmatic, adaptive, randomized, multicenter phase II/III study evaluating IFX-1 for the treatment of COVID-19 related severe pneumonia. The study consists of two parts: Phase II, an open-label, randomized, 2-arm phase evaluating best supportive care (BSC) + IFX-1 (Arm A) and BSC alone …

pneumonia
SARS
Inflarx Site
 (81.7 away) Contact site
  • 55 views
  • 16 Jun, 2021
  • +26 other locations
A Study of the Efficacy and Safety of Upadacitnib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and severely active Crohn's disease (CD).

corticosteroids
mucosal inflammation
endoscopy
conventional treatment
immunosuppressive agents
Medisch Spectrum Twente /ID# 170298
 (0.3 away) Contact site
  • 824 views
  • 02 Jun, 2021
  • +730 other locations
A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients

The purpose of this study is to determine whether acetylsalicylic acidis effective on the recurrence and survival of colon cancer patients.

Ziekenhuisgroep Twente
 (13.8 away) Contact site
  • 33 views
  • 23 Jan, 2021
  • +33 other locations
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases

Colorectal cancer patients with initially unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy. However, the optimal neoadjuvant induction regimen has not been defined, and no consensus exist on criteria for resectability. In this study colorectal cancer patients with initially unresectable liver-only metastases, as prospectively …

ct scan
primary tumor
bevacizumab
systemic therapy
folfiri regimen
Ziekenhuisgroep Twente
 (4.9 away) Contact site
  • 177 views
  • 23 Jan, 2021
  • +63 other locations
Management of Low-risk (Grade I and II) DCIS

A substantial number of DCIS lesions will never form a health hazard, particularly if it concerns slow-growing low-risk DCIS (grade I and II). This implies that many women might be unnecessarily going through intensive treatment resulting in a decrease in quality of life and an increase in health care costs, …

hormone therapy
invasive breast cancer
mammogram
digital mammography
cancer
Gelre ziekenhuizen
 (29.9 away) Contact site
  • 410 views
  • 17 Feb, 2021
  • +44 other locations
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation …

infarct
myocardial infarction
arterial disease
diabetes
percutaneous coronary intervention
5280049 - Medisch Spectrum Twente
 (0.5 away) Contact site
  • 1118 views
  • 18 Jun, 2021
  • +3422 other locations
Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Japan Study

Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is estimated based on two angiographic projections. Studies have shown a good correlation with the present wire-based standard approach Fractional Flow Reserve (FFR) for assessment of intermediate coronary stenosis. The purpose of the …

stable angina
chest pain
coronary artery stenosis
angiography
adenosine
Medisch Spectrum Twente
 (0.3 away) Contact site
  • 21 views
  • 07 May, 2021
  • +58 other locations
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome

Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells. Some people with MDS have a risk of the disease progressing to acute myeloid leukemia (AML), and a risk …

anemia
azacitidine
leukemia
remission
myeloid leukemia
Medisch Spectrum Twente /ID# 223012
 (0.3 away) Contact site
  • 27 views
  • 13 Jun, 2021
  • +266 other locations