Enschede, Netherlands Clinical Trials

A listing of Enschede, Netherlands clinical trials actively recruiting patients volunteers.

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Found 62 clinical trials
Impact of Nationwide Enhanced Implementation of Best Practices in Pancreatic Cancer Care (PACAP-1)

PACAP-1 will evaluate to what extent an enhanced implementation of best practices in pancreatic cancer care leads to a prolonged survival and improvement of quality of life as compared to current practice.

Isala Klinieken
 (39.7 away) Contact site
  • 23 Jan, 2021
  • +15 other locations
Efficacy Safety and Tolerability Study of Apremilast to Treat Early Oligoarticular Psoriatic Arthritis.

This clinical study will test the effects of a drug called apremilast in oligoarticular psoriatic arthritis with less than 5 years of disease duration. In previous studies, apremilast has been shown to be safe and efficacious in reducing signs and symptoms of psoriatic arthritis, as well as improving physical function. …

Medisch Spectrum Twente
 (0.3 away) Contact site
  • 14 Jun, 2021
  • +267 other locations
Therapeutic Instillation of Mistletoe

The aim of this phase III study is to assess the efficacy of abnobaVISCUM 900 compared with Mitomycin C (MMC) monotherapy in patients with superficial bladder carcinoma by evaluation of the time to tumor recurrence. Secondary objective is to evaluate the safety of abnobaVISCUM 900, in particular, to compare the …

Klinik f r Urologie, Kinderurologie und Urologische Onkologie - St. Antonius Hospital Gronau
 (6.3 away) Contact site
  • 13 Feb, 2021
  • +39 other locations
Endocrine Therapy Plus CDK4/6 in First or Second Line for Hormone (SONIA) Receptor Positive Advanced Breast Cancer

Given the uncertain benefit in efficacy of adding CDK 4/6 to first rather than second line endocrine treatment, the aim of this project is to evaluate whether the sequence of an aromatase inhibitor plus CDK 4/6 in first line followed by fulvestrant in second line is superior to the sequence …

gilbert's syndrome
aromatase inhibitor
breast cancer
 (13.5 away) Contact site
  • 23 Jan, 2021
  • +71 other locations
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low Hormone Receptor Positive Metastatic Breast Cancer

This study will evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy in human epidermal growth factor receptor (HER)2-low, hormone receptor (HR) positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting.

Research site
 (4.9 away) Contact site
  • 24 May, 2021
  • +245 other locations
Very Early PET-response Adapted Targeted Therapy for Advanced Hodgkin Lymphoma: a Single -Arm Phase II Study

The main objective of this trial is to assess whether treatment adaptation based on a very early FDG-PET/CT results in improved efficacy while minimizing treatment toxicity in advanced stage Hodgkin Lymphoma (HL) patients treated with brentuximab vedotin (BV)-containing regimens.

Deventer Ziekenhuis
 (31.3 away) Contact site
  • 24 Jan, 2021
  • +20 other locations
Nortriptyline for the Treatment of Functional Dyspepsia

Functional dyspepsia (FD) is a common functional gastrointestinal disorder characterized by upper abdominal discomfort/pain and/or symptoms of meal-related fullness/satiety. There is currently no definitive therapy that is beneficial for all FD patients. Accumulating evidence suggests efficacy of tricyclic antidepressants (TCAs) in FD. However, no firm conclusion can be drawn currently …

functional gastrointestinal disorder
organic disease
proton pump inhibitors
 (45.1 away) Contact site
  • 22 Jan, 2021
  • +11 other locations
Induction Therapy With Vemurafenib and Cobimetinib to Optimize Nivolumab and Ipilimumab Therapy

Rationale The combination of ipilimumab and nivolumab induces relatively high response rates and promising response depth in late stage melanoma. Nevertheless, it takes time till responses occur and still a significant number of patients do not benefit from treatment, due to rapid progressive disease or resistance to therapy. In contrast …

 (38.1 away) Contact site
  • 24 Jan, 2021
  • +12 other locations
COVID-19 Resuscitation Plans and Decisions on Escalation and Limitation of Treatment

During the Corona Virus Pandemic health care resources have become scare, and the pandemic has brought forth the need for risk stratification of patients suffering from COVID19 in order to allocate resources appropriately. One of scarcest resources is Intensive Care treatment, mostly related to the need for invasive ventilation or …

 (45.1 away) Contact site
  • 17 Feb, 2021
  • +6 other locations
PRotEin Provision in Critical IllneSs

Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission. Increased dietary protein delivery might attenuate skeletal muscle wasting and its subsequent effects on post-ICU function. The investigators will conduct a 824 patient, randomised controlled, quadruple blinded parallel group …

Gelderse Vallei Ede
 (53.4 away) Contact site
  • 02 Apr, 2021
  • +8 other locations