Drachten, Netherlands Clinical Trials

A listing of Drachten, Netherlands clinical trials actively recruiting patients volunteers.

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Found 10 clinical trials
Endocrine Therapy Plus CDK4/6 in First or Second Line for Hormone (SONIA) Receptor Positive Advanced Breast Cancer

Given the uncertain benefit in efficacy of adding CDK 4/6 to first rather than second line endocrine treatment, the aim of this project is to evaluate whether the sequence of an aromatase inhibitor plus CDK 4/6 in first line followed by fulvestrant in second line is superior to the sequence …

aromatase inhibitor
fulvestrant
adenocarcinoma
progesterone
breast cancer
Tjongerschans
 (10.7 away) Contact site
  • 71 views
  • 23 Jan, 2021
  • +71 other locations
A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients

The purpose of this study is to determine whether acetylsalicylic acidis effective on the recurrence and survival of colon cancer patients.

Antonius Ziekenhuis
 (17.1 away) Contact site
  • 33 views
  • 23 Jan, 2021
  • +33 other locations
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases

Colorectal cancer patients with initially unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy. However, the optimal neoadjuvant induction regimen has not been defined, and no consensus exist on criteria for resectability. In this study colorectal cancer patients with initially unresectable liver-only metastases, as prospectively …

folfox regimen
BRAF
folfiri regimen
cancer
liver surgery
Medisch Centrum Leeuwarden, loc. Zuid
 (13.0 away) Contact site
  • 177 views
  • 23 Jan, 2021
  • +63 other locations
The Drug Rediscovery Protocol (DRUP Trial)

This is a prospective, non-randomized clinical trial that aims to describe the efficacy and toxicity of commercially available, targeted anticancer drugs* prescribed for treatment of patients with advanced cancer with a potentially actionable variant as revealed by a genomic or protein expression test. The study also aims to simplify patient …

sunitinib
advanced cancer
solid neoplasm
advanced malignant solid tumor
pembrolizumab
Ziekehuis Nij Smellinghe
 (2.0 away) Contact site
  • 260 views
  • 18 Mar, 2021
  • +34 other locations
Pharmacogenetics Use For Further Treatment Improvement in childreN

There is large heterogeneity in treatment response to asthma medication and a one-size fits all approach based on current guidelines might not fit all children with asthma. It is expected that children with one or more variant alleles (Arg16Arg and Arg16Gly) within the beta2 adrenergic receptor (ADRB2) gene coding for …

Medisch Centrum Leeuwarden
 (12.4 away) Contact site
  • 6 views
  • 01 May, 2021
  • +22 other locations
Image-guided De-escalation of Neo-adjuvant Chemotherapy in HER2-positive Breast Cancer: the TRAIN-3 Study

This is a multicenter, single arm, phase II study evaluating the efficacy of image-guided de-escalating neoadjuvant treatment with paclitaxel, Herceptin (trastuzumab), carboplatin, and pertuzumab (PTC-Ptz) in stage II-Ill HER2-positive breast cancer.

adjuvant chemotherapy
core needle biopsy
paclitaxel
herceptin
erbb2
Tjongerschans
 (10.7 away) Contact site
  • 19 views
  • 24 Jan, 2021
  • +51 other locations
Triple-B Study;Carboplatin-cyclophosphamide Versus Paclitaxel With or Without Atezolizumab as First-line Treatment in Advanced Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is a difficult to treat molecular subtype with a poor survival. TNBC can be divided into at least two molecular entities; BRCA-like and non-BRCA-like. In this trial we would like to investigate whether a molecular subgroup exists within TNBCs that derives a benefit from atezolizumab …

paclitaxel
immunostimulant
tumor cells
carboplatin
cish
Nijsmellinghe
 (2.2 away) Contact site
  • 36 views
  • 02 Feb, 2021
  • +48 other locations
A Safety Study of Lenalidomide in Previously Untreated Adult Multiple Myeloma Patients Who Are Not Eligible for Transplant

This post authorization safety study is designed as prospective non interventional study for patients with newly diagnosed multiple myeloma who are not eligible for transplant. The objective is to compare the incidence of cardiovascular events between patients treated with a first-line lenalidomide containing regimen and those treated with a first-line …

cancer
lenalidomide
revlimid
Nij Smellinghe
 (2.2 away) Contact site
  • 170 views
  • 26 Mar, 2021
  • +161 other locations
Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal Cancer

In this study the characteristics and alterations of the gut microbiome during chemotherapy for metastasized or irresectable CRC are studied, as well as the relation between the gut microbiome and the effects of chemotherapy.

vegf
bevacizumab
metastasis
measurable disease
vascular endothelial growth factor
Ziekenhuis Nij Smellinghe
 (2.0 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +10 other locations
A National Study for Blood Based Response Monitoring of B-cell Lymphoma Patients

Observational prospective study. Patients with DLBCL and HGBCL will be enrolled in the study to collect samples for developing a blood based assay allowing biomarker driven treatment in the future.

b-cell lymphoma
diffuse large b-cell lymphoma
chop regimen
r-chop
r-chop regimen
Nij Smellinghe
 (2.0 away) Contact site
  • 2 views
  • 26 Jan, 2021
  • +57 other locations