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  • A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis

    Phase

    3

    Span

    201 weeks

    Sponsor

    Janssen Research & Development, LLC

    Buenos Aires

    Recruiting

  • A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

    This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety and efficacy of tezepelumab in adults with moderate to very severe chronic obstructive pulmonary disease (COPD) receiving inhaled maintenance therapy and having had at least 2 moderate, or 1 severe, COPD exacerbations in the 12 months prior to Visit 1. Subjects will receive monthly subcutaneous injection of one of two different doses of tezepelumab, or placebo, with a maximum treatment duration of 76 weeks and a minimum of 52 weeks. The study also includes a off-treatment safety follow-up period of 12 weeks.

    Phase

    3

    Span

    219 weeks

    Sponsor

    AstraZeneca

    Buenos Aires

    Recruiting

  • A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

    Phase

    3

    Span

    148 weeks

    Sponsor

    Sanofi

    Buenos Aires

    Recruiting

  • Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

    Phase

    3

    Span

    157 weeks

    Sponsor

    Incyte Corporation

    Buenos Aires

    Recruiting

  • Treatment of Type 1 Diabetes With Anti-OX40L Bispecific With Anti-TNF Activity In a Single Nanobody® Molecule

    The total study duration will be up to 83 weeks including Screening and Safety follow-up period.

    Phase

    2

    Span

    185 weeks

    Sponsor

    Sanofi

    Buenos Aires

    Recruiting

  • A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

    The primary objective of this clinical trial is to assess the radiographic progression free survival (rPFS) of BMS-986365 versus investigator's choice comprising Docetaxel + Prednisone/Prednisolone or Abiraterone + Prednisone/Prednisolone or Enzalutamide. In Part 1, participants will be randomized 1:1:1 to one of the two BMS-986365 dose levels, or to the active comparator arm (investigator's choice). In Part 2 of the study, participants will be randomized 1:1 between BMS-986365 selected dose, or to the active comparator arm (investigator's choice).

    Phase

    3

    Span

    202 weeks

    Sponsor

    Celgene

    Buenos Aires

    Recruiting

  • An Ophthalmic Safety Study in Patients With Breast Cancer

    This is a multicentre study assessing the ophthalmic safety in patients who are participating in a qualifying study. The study will include two cohorts of at least 60 individuals each. To be able to account for events associated with aging, worsening of pre-existing conditions, etc., ophthalmic study assessments will be performed in parallel in two cohorts at the same timepoints. The duration of the study assessment period will be approximately 12 months. Longer duration of the study would result in additional patient burden.

    Phase

    N/A

    Span

    122 weeks

    Sponsor

    AstraZeneca

    Buenos Aires

    Recruiting

  • A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

    The purpose of this study is to assess the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS ≥ 1. Rilvegostomig in combination with trastuzumab and chemotherapy will be evaluated in a separate arm (Arm C) to assess the contribution of each component in the experimental arm. This study will be conducted at up to 200-250 sites globally in approximately 25 countries.

    Phase

    3

    Span

    298 weeks

    Sponsor

    AstraZeneca

    Buenos Aires

    Recruiting

  • Nipocalimab in Moderate to Severe Sjogren's Disease

    This clinical development program for nipocalimab in SjD includes 2 identical double blind, placebo-controlled studies to evaluate the efficacy, safety, and tolerability of nipocalimab in participants greater than or equal to (>=) 18 years of age with moderate to severe SjD.

    Phase

    3

    Span

    286 weeks

    Sponsor

    Janssen Research & Development, LLC

    Buenos Aires

    Recruiting

  • A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma

    Phase

    3

    Span

    401 weeks

    Sponsor

    BeiGene

    Buenos Aires

    Recruiting

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