Utsunomiya, Japan Clinical Trials

A listing of Utsunomiya, Japan clinical trials actively recruiting patients volunteers.

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Found 24 clinical trials
Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)

The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trastuzumab in combination with SOC chemotherapy in participants with HER2-positive gastric cancer. The primary hypotheses of the study are that pembrolizumab plus trastuzumab in combination with chemotherapy is superior …

HER2
metastasis
gimeracil
cancer
oxaliplatin
Tochigi Cancer Center ( Site 2627)
 (1.3 away) Contact site
  • 303 views
  • 25 Nov, 2020
  • +196 other locations
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive HER2-Negative Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

The purpose of this study is to evaluate the efficacy of zolbetuximab plus capecitabine and oxaliplatin (CAPOX) compared with placebo plus CAPOX (as first-line treatment) as measured by Progression Free Survival (PFS). This study will also evaluate efficacy, safety and tolerability of zolbetuximab, as well as its effects on quality …

Site JP81005
 (0.0 away) Contact site
  • 224 views
  • 07 Oct, 2020
  • +180 other locations
A Study of Baricitinib (LY3009104) in Children and Adolescents With Atopic Dermatitis

The reason for this study is to see if the study drug called baricitinib works and is safe in children and teenage participants with atopic dermatitis.

topical agents
corticosteroids
ly3009104
eczema
baricitinib
Dokkyo Medical University Hospital
 (6.5 away) Contact site
  • 102 views
  • 25 Nov, 2020
  • +180 other locations
This is a Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS).

The purpose of this study is to demonstrate superiority of secukinumab at Week 16, based on Hidradenitis Suppurativa Clinical Response (HiSCR) rates versus placebo, along with the maintenance of efficacy of secukinumab at Week 52 in subjects with moderate to severe HS. Moreover, this study will also assess the safety …

antiseptics
secukinumab
hidradenitis
abscess
Novartis Investigative Site
 (6.5 away) Contact site
  • 1025 views
  • 08 Oct, 2020
  • +121 other locations
Study of Subcutaneous Risankizumab Injection to Assess Change in Palmoplantar Pustulosis Area and Severity Index [PPPASI] in Adult Japanese Participants With Palmoplantar Pustulosis

Palmoplantar pustulosis is a chronic inflammatory skin disease that causes repeated on and off symptoms like erythema (reddening, irritation), vesicle (swelling, cyst), pustules, scale, and crusts in palms and soles. This study evaluates how well risankizumab works compared to placebo (no medicine) to treat palmoplantar pustulosis. Study will assess change …

risankizumab
phototherapy
corticosteroids
erythema
Dokkyo Medical University Hospital /ID# 221210
 (6.5 away) Contact site
  • 7 views
  • 25 Oct, 2020
  • +45 other locations
A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis

The study will investigate the efficacy and safety of an oral dose of AJM300 960 milligram (mg)/dose administered three times daily for 8 weeks in participants with active ulcerative colitis.

hematochezia
mesalamine
AJM300/CT3 trial site 29
 (9.0 away) Contact site
  • 34 views
  • 20 May, 2020
  • +81 other locations
A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG)

The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of eculizumab in the treatment of pediatric refractory gMG based on change from Baseline in the Quantitative Myasthenia Gravis (QMG) score for disease severity.

acetylcholine
generalized myasthenia gravis
immunosuppressive agents
acetylcholinesterase inhibitors
immune globulin
Dokkyo Medical University Hospital
 (6.5 away) Contact site
  • 18 views
  • 27 Aug, 2020
  • +13 other locations
A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments

The purpose of this study is to evaluate the efficacy of ustekinumab in participants with active polymyositis (PM)/dermatomyositis (DM) despite receiving 1 or more standard-of-care treatments (for example, glucocorticoids and/or immunomodulators).

polymyositis
glucocorticoids
dermatomyositis
azathioprine
methotrexate
Dokkyo Medical University Hospital
 (6.5 away) Contact site
  • 8 views
  • 28 Oct, 2020
  • +37 other locations
KW-3357 Study in Patients With Early Onset Severe Preeclampsia

The purpose of this study is to evaluate the efficacy of intravenous KW-3357 in patients with early-onset severe preeclampsia by comparing the prolongation days of pregnancy with that of placebo.

severe pre-eclampsia
Dokkyo Medical University Hospital
 (9.8 away) Contact site
  • 2 views
  • 22 Oct, 2020
  • +60 other locations
To Evaluate Efficacy and Long-term Safety of Ozanimod in Japanese Subjects With Moderately to Severely Active Ulcerative Colitis

Japanese patients with moderate or severe active ulcerative colitis as a subject when ozanimod 0.46 mg or 0.92 mg is orally administered is evaluated about dose response, efficacy and safety with placebo as a control.

sigmoidoscopy or colonoscopy
hematochezia
flexible sigmoidoscopy
endoscopy
Kanke Gastrointestinal Clinic
 (3.4 away) Contact site
  • 26 views
  • 08 Oct, 2020
  • +54 other locations