Ota, Japan Clinical Trials

A listing of Ota, Japan clinical trials actively recruiting patients volunteers.

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Found 577 clinical trials
Study of Capmatinib and Spartalizumab/Placebo in Advanced NSCLC Patients With MET Exon 14 Skipping Mutations

A double-blind, placebo controlled, randomized, phase II study evaluating the efficacy and safety of capmatinib (INC280) and spartalizumab (PDR001) combination therapy versus capmatinib and placebo as first line treatment for locally advanced or metastatic non-small cell lung cancer (NSCLC) patients with MET exon 14 skipping (METex14) mutations

lung carcinoma
measurable disease
EGFR
metastasis
systemic therapy
Novartis Investigative Site
 (6.7 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +20 other locations
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.

This is a randomized, double blind, active-controlled, parallel group, multicenter 52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus mepolizumab 300 mg administered by subcutaneous (SC) injection in patients with relapsing or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive therapy. All …

asthma
vasculitis
granulomatosis
purpura
immunosuppressive agents
Research Site
 (9.4 away) Contact site
  • 20 views
  • 01 Aug, 2021
  • +79 other locations
Efficacy and Safety of Olaparib Olaparib + Bevacizumab Compared to Bevacizumab + 5-Fluorouracil (FU)

This is an efficacy and safety study of olaparib alone or in combination with bevacizumab being compared to bevacizumab with Fluorouracil (5-FU) in participants with unresectable or metastatic colorectal cancer (CRC) who have not progressed following first-line induction of FOLFOX with bevacizumab. Hypothesis 1 - Olaparib + Bevacizumab is superior …

folfox regimen
fluorouracil
adenocarcinoma
colorectal adenocarcinoma
solid tumour
The Cancer Institute Hospital of JFCR ( Site 0659)
 (6.7 away) Contact site
  • 10 views
  • 01 Aug, 2021
  • +122 other locations
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical events committee (CEC)-adjudicated morbidity or mortality (M/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.

heart disease
septal defect
ventricular septal defect
macitentan 10 mg
connective tissue disease
Toho University Medical Center Omori Hospital
 (0.7 away) Contact site
  • 56 views
  • 16 Jul, 2021
  • +265 other locations
Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance

This is a Phase 3 open-label, multicenter, randomized, active-controlled study designed to compare the efficacy and safety and tolerability of P1101 compared with ANA after 12 months of treatment as second-line therapy for subjects with ET who have had a suboptimal or failed response to HU.

ropeginterferon alfa-2b
hydroxyurea
interferon
neutrophil count
thrombosis
NTT Medical Center Tokyo
 (4.6 away) Contact site
  • 0 views
  • 20 Mar, 2021
  • +50 other locations
Study of AMG 910 in Subjects With CLDN18.2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma

To evaluate the safety and tolerability of AMG 910 in adult subjects, and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D)

Research Site
 (7.7 away) Contact site
  • 0 views
  • 25 Jun, 2021
  • +38 other locations
A Study to Evaluate U3-1402 in Subjects With Advanced or Metastatic Colorectal Cancer

This study is designed to primarily evaluate the safety and efficacy of U3-1402 in participants with advanced or metastatic colorectal cancer (CRC) who have received at least 2 prior lines of therapy and will explore clinical benefit according to human epidermal growth factor receptor 3 (HER3) tumor expression level in …

vegf
thromboplastin
anticoagulants
irinotecan
aptt
The Cancer Institute Hospital of JFCR
 (6.7 away) Contact site
  • 0 views
  • 13 Feb, 2021
  • +42 other locations
Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)

This study will assess safety and treatment activity of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab with or without platinum chemotherapy in participants with advanced or metastatic non-small cell lung cancer.

Showa Univeristy Hospital
 (3.4 away) Contact site
  • 12 views
  • 21 Jul, 2021
  • +22 other locations
A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine

The main purpose of this study is to evaluate the efficacy and safety of galcanezumab for the preventive treatment of chronic migraine in participants 12 to 17 years of age. The primary objective is to demonstrate the superiority of galcanezumab versus placebo in the reduction of monthly migraine headache days …

Tokyo Headache Clinic
 (8.1 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • +78 other locations
A Study of TAK-994 in Adults With Narcolepsy

Adults with narcolepsy who have completed the TAK-994-1501 study will be able to take part in this study. The main aim of this study is to check if participants have side effects from TAK-994. Participants will take one of 3 different TAK-994 dose for 8 weeks. Then, half the participants …

Sleep Support Clinic,Dept of Psychosomatic Medicine/Psychiatry
 (3.2 away) Contact site
  • 8 views
  • 07 Jul, 2021
  • +151 other locations