San Giovanni Rotondo (FG), Italy Clinical Trials

A listing of San Giovanni Rotondo (FG), Italy clinical trials actively recruiting patients volunteers.

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Found 63 clinical trials
Study of the Efficacy and Safety of Lonafarnib / Ritonavir With and Without Pegylated Interferon -Alfa-2a

Two LNF-containing regimens will be evaluated in the D-LIVR Phase 3 study: (1) LNF/RTV/PEG IFN-alfa-2a and (2) LNF/RTV. Each of these arms will have efficacy endpoints that measure clinical benefit with regard to viral suppression and alanine aminotransferase (ALT) normalization. For each LNF-containing regimen, a composite endpoint of EOT (48 …

Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
 (20.2 away) Contact site
  • 24 Mar, 2021
  • +177 other locations
Safety Tolerability and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis

The primary objective of this study is to evaluate whether cilofexor reduces the risk of fibrosis progression among non-cirrhotic adults with primary sclerosing cholangitis (PSC).

platelet count
Fondazione Policlinico Universitario Agostino Gemelli
 (170.9 away) Contact site
  • 25 Jul, 2021
  • +231 other locations
PAXG Out in the Country

The objective of this study is to assess the reproducibility of PAXG regimen as first-line/primary chemotherapy in daily clinical practice in Pancreatic Ductal Adenocarcinoma (PDAC) borderline resectable, locally advanced or metastatic patients out of a large volume center.

pancreatic adenocarcinoma
resectable pancreatic ductal adenocarcinoma
Azienda Ospedaliera Universitaria Ospedali Riuniti di Foggia
 (19.3 away) Contact site
  • 19 Feb, 2021
  • +29 other locations
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System

Primary central nervous system lymphomas are rare aggressive malignancies, usually treated in two steps: an induction phase (where a combination of chemotherapy is given) followed by a consolidation phase (where patients usually receive one of the following: whole-brain irradiation, chemotherapy supported by autologous stem-cell transplantation, other type of chemotherapy, or …

maintenance treatment
whole-brain radiotherapy
Bari IRCCS Istituto Tumori
 (71.6 away) Contact site
  • 19 Jun, 2021
  • +41 other locations
PN-943 in Adults With Moderate to Severe Active Ulcerative Colitis (UC)

The purpose of the study is to evaluate the safety, tolerability, and clinical efficacy of PN-943 450 mg twice daily [BID] and PN-943 150 mg BID, compared with placebo BID, in subjects with moderate to severe active Ulcerative Colitis (UC).

Protagonist Investigational Site
 (93.5 away) Contact site
  • 20 Jul, 2021
  • +81 other locations
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma

This study will evaluate the efficacy and safety of belantamab mafodotin in combination with pomalidomide and dexamethasone (Arm A) compared with that of combination of pomalidomide, bortezomib and dexamethasone (Arm B) in participants with relapsed/refractory multiple myeloma (RRMM).

measurable disease
GSK Investigational Site
 (171.9 away) Contact site
  • 26 Jul, 2021
  • +73 other locations
Study of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)

The purpose of this study is to assess the preliminary antitumor activity, safety and tolerability of tepotinib in combination with cetuximab in participants with RAS/BRAF wild-type left-sided Metastatic Colorectal Cancer (mCRC) having acquired resistance to anti-epidermal growth factor receptor (EGFR) antibody targeted therapy due to mesenchymal epithelial transition (MET) amplification.

Istituto Nazionale Tumori, Fondazione G. Pascale Napoli
 (95.8 away) Contact site
  • 01 Aug, 2021
  • +52 other locations
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

The trial is open to all patients with a diagnosis of acute promyelocytic leukemia (APL) who are PCR-positive for the PML-RAR transcript and less than 18 years of age.

AOU Policlinico Dipartimento di Pediatria
 (71.6 away) Contact site
  • 21 Mar, 2021
  • +28 other locations
Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)

The purpose of the study is to assess efficacy, safety and tolerability of treatment with zibotentan and dapagliflozin in combination and alone, compared with placebo in participants with chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) between 20 and 60 mL/min/1.73^2.

Research site
 (71.6 away) Contact site
  • 13 Jul, 2021
  • +149 other locations
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

This open-label, randomized study for evaluating the efficacy and safety of single agent belantamab mafodotin when compared to pom/dex in participants with RRMM. Participants will be randomized in a 2:1 ratio to receive either single agent belantamab mafodotin or pom/dex. Belantamab mafodotin will be administered intravenously at 2.5 milligram (mg)/kilogram …

measurable disease
refractory multiple myeloma
GSK Investigational Site
 (168.2 away) Contact site
  • 29 Apr, 2021
  • +103 other locations