Dublin 4, Ireland Clinical Trials

A listing of Dublin 4, Ireland clinical trials actively recruiting patients volunteers.

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Found 134 clinical trials
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

cancer
tyrosine
lung carcinoma
breast cancer
measurable disease
St. Vincent's University Hospital
 (1.9 away) Contact site
  • 0 views
  • 15 Sep, 2021
  • +204 other locations
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children

The study is being done to test the safety of a cancer drug called larotrectinib in children. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib blocks the actions of these NTRK genes in cancer cells and can therefore be used to treat cancer. …

primary cancer
metastasis
breast cancer
solid tumor
metastatic solid tumor
Our Lady's Hospital For Sick Children
 (3.7 away) Contact site
  • 0 views
  • 17 Sep, 2021
  • +71 other locations
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

The main purpose of this study is : To establish which number of doses of gemtuzumab ozogamicin (up to a maximum of 3 doses) is tolerated and can be safety delivered in combination with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal …

remission
minimal residual disease
cyclophosphamide
blast cells
residual tumor
Our Lady's Hospital for Sick Children
 (1.9 away) Contact site
  • 0 views
  • 05 Sep, 2021
  • +60 other locations
A Study to Evaluate the Safety Pharmacokinetics and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation

The purpose of this study is to evaluate the safety of ivacaftor treatment, and PK of ivacaftor and metabolites in subjects with cystic fibrosis (CF) who are <24 months of age at treatment initiation and have an ivacaftor-responsive CF transmembrane conductance regulator (CFTR) gene mutation.

sweat test
ivacaftor
fibrosis
 (1.9 away) Contact site
  • 0 views
  • 28 Jan, 2021
  • +22 other locations
Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI

This study is designed to provide long-term CDZ173 treatment, a selective PI3K inhibitor, to the patients with genetically activated PI3K, i.e., patients with APDS/PASLI who participated in the CCDZ173X2201 study or who were treated previously with PI3K inhibitors other than CDZ173. The study is open-label designed to establish the long-term …

Novartis Investigative Site
 (1.9 away) Contact site
  • 0 views
  • 04 Sep, 2021
  • +8 other locations
Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers

The primary objectives in the dose escalation phase are to evaluate safety and pharmacokinetics (PK) in order to determine the selected dose level(s) for expansion of REGN3767 as monotherapy and in combination with cemiplimab in patients with advanced malignancies, including lymphoma. The primary objectives in the dose expansion phase are …

primary cancer
bone marrow procedure
lymphoma
measurable disease
pd-l1
St. Vincents University Hospital
 (1.1 away) Contact site
  • 392 views
  • 05 Aug, 2021
  • +43 other locations
A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma

The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement.

St Vincent's University Hospital
 (1.0 away) Contact site
  • 51 views
  • 26 Sep, 2021
  • +341 other locations
Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS

This is a Phase III, multi-centre, randomized, double-blind, placebo-controlled, parallel-group study to evaluate Safety and Efficacy of Tauroursodeoxycholic (TUDCA) as add-on Treatment in Patients Affected by Amyotrophic Lateral Sclerosis (ALS).

pulmonary function test
primary lateral sclerosis
riluzole
dysphagia
Trinity College Dublin
 (1.9 away) Contact site
  • 139 views
  • 28 Mar, 2021
  • +32 other locations
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in the treatment of adults who have high-risk early-stage estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer. The primary …

cyclophosphamide
estrogen
progesterone
EGFR
epidermal growth factor receptor
St. James s Hospital ( Site 1553)
 (2.0 away) Contact site
  • 188 views
  • 26 Sep, 2021
  • +287 other locations
Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)

This study will evaluate the safety and efficacy of pembrolizumab (MK-3475) versus placebo as adjuvant therapy in participants with hepatocellular carcinoma (HCC) and complete radiological response after surgical resection or local ablation. The primary hypotheses of this study are that adjuvant pembrolizumab is superior to placebo with respect to: 1) …

alpha fetoprotein
pembrolizumab
ct scan
hepatitis
St Vincent's University Hospital ( Site 0498)
 (1.1 away) Contact site
  • 137 views
  • 27 Sep, 2021
  • +257 other locations