Dublin 4, Ireland Clinical Trials

A listing of Dublin 4, Ireland clinical trials actively recruiting patients volunteers.

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Found 139 clinical trials
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine …

Saint Vincents University Hospital
 (1.9 away) Contact site
  • 17 Jul, 2021
  • +425 other locations
Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

The primary objectives of this study are to evaluate the safety and efficacy of filgotinib during induction and maintenance treatment of moderately to severely active Crohn's disease (CD) in participants who are biologic-naive and biologic-experienced. Participants who complete the study, or do not meet protocol response or remission criteria at …

tumor necrosis factor alpha
crohn's disease
Beaumont Hospital
 (1.9 away) Contact site
  • 04 Jul, 2021
  • +551 other locations
Statins for Venous Event Reduction in Patients With Venous Thromboembolism

The standard or usual treatment for patients diagnosed with deep vein thrombosis or pulmonary embolism is treatment with blood thinners (called anticoagulants). While treatment of blood clots with blood thinners is effective, some research has shown that adding a statin (medication used to lower cholesterol) may give extra protection. It …

Mater Misericordiae University Hospital
 (2.8 away) Contact site
  • 05 Mar, 2021
  • +11 other locations
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

The trial is open to all patients with a diagnosis of acute promyelocytic leukemia (APL) who are PCR-positive for the PML-RAR transcript and less than 18 years of age.

Our Lady's Children's Hospital Crumlin
 (1.9 away) Contact site
  • 21 Mar, 2021
  • +28 other locations
Early Detection of High Grade Ovarian Cancer Using Uterine Lavage EHUD Study and Duplex Sequencing

In Phase I the sponsor will systematically test conditions for lavage filtration that increase tumor cell fraction without reducing tumor mutation yield. The Sponsor will also transition all lavages to luteal phase timing, when endometrial shedding is least. In Phase II the Sponsor will examine our data in context of …

St. James Hospital
 (2.8 away) Contact site
  • 07 Apr, 2021
  • +8 other locations
International Study to Evaluate Two Programs of Support for Patients With Advanced Cancer and Their Families

The overall aim of this project is to evaluate the effectiveness, cost-effectiveness and mechanisms of action of two psychoeducational interventions (a face-to-face nurse-led intervention called FOCUS+ and an eHealth intervention called iFOCUS) aimed at improving the emotional function and self-efficacy of patients with advanced cancer and their family caregiver. Both …

St. Vincent's University Hospital
 (2.2 away) Contact site
  • 10 Jul, 2021
  • +11 other locations
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients

This is a phase 3, multicenter, randomized, double-blind, placebo-controlled trial designed to compare the efficacy and safety of the humanized monoclonal anti CD19 antibody tafasitamab plus lenalidomide in addition to R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) versus R-CHOP in previously untreated, high-intermediate and high-risk patients with newly-diagnosed DLBCL

MorphoSys Research Site
 (1.9 away) Contact site
  • 03 Jun, 2021
  • +267 other locations
Confirm Safety and Performance of Avance Solo and Avance Solo Adapt NPWT Systems

The primary objective of this post market clinical follow-up (PMCF) investigation is to confirm the safety and performance of AvanceSolo and AvanceSolo Adapt NPWT Systems in low to moderate exuding chronic wounds when used in accordance with the Instructions for Use, for up to 28 days.

diabetic foot
St James's Hospital
 (1.9 away) Contact site
  • 20 Jul, 2021
  • +11 other locations
Safety Efficacy and PK of BIVV001 in Pediatric Patients With Hemophilia A

Primary Objective: To evaluate the safety of BIVV001 in previously treated pediatric subjects with hemophilia A Secondary Objectives: To evaluate the efficacy of BIVV001 as a prophylaxis treatment To evaluate the efficacy of BIVV001 in the treatment of bleeding episodes To evaluate BIVV001 consumption for prevention and treatment of bleeding …

Investigational Site Number 3720001
 (3.8 away) Contact site
  • 24 Jul, 2021
  • +30 other locations
Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction With First-Line Chemotherapy Plus Pembrolizumab in Triple Negative Breast Cancer (TNBC) (MK-7339-009/KEYLYNK-009)

The purpose of this study is to compare the efficacy of olaparib (MK-7339) plus pembrolizumab (MK-3475) with chemotherapy plus pembrolizumab after induction with first-line chemotherapy plus pembrolizumab in triple negative breast cancer (TNBC). The primary hypotheses are: Olaparib plus pembrolizumab prolongs progression-free survival (PFS) compared with chemotherapy plus pembrolizumab. Olaparib …

measurable disease
St Vincents University Hospital ( Site 0900)
 (1.9 away) Contact site
  • 04 Aug, 2021
  • +133 other locations