Dublin 4, Ireland Clinical Trials

A listing of Dublin 4, Ireland clinical trials actively recruiting patients volunteers.

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Found 17 clinical trials
Surgery in Treating Patients With Neuroblastoma

RATIONALE: Surgery may be an effective treatment for neuroblastoma. PURPOSE: This phase II trial is studying how well surgery works in treating patients with neuroblastoma.

Our Lady's Hospital for Sick Children Crumlin
 (3.1 away) Contact site
  • 73 views
  • 07 Nov, 2020
  • +18 other locations
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

This study will evaluate the efficacy and safety of olaparib (MK-7339) monotherapy in participants with multiple types of advanced cancer (unresectable and/or metastatic) that: 1) have progressed or been intolerant to standard of care therapy; and 2) are positive for homologous recombination repair mutation (HRRm) or homologous recombination deficiency (HRD).

St. Vincent's University Hospital ( Site 1653)
 (1.1 away) Contact site
  • 135 views
  • 20 Jun, 2021
  • +146 other locations
A Study of Biomarker-Directed Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)

This study will investigate the utility of biomarker-based triage for study participants with advanced non-small cell lung cancer (NSCLC) without prior systemic therapy. Study participants within groups defined by a biomarker-based classifier (gene expression profile [GEP] and tumor mutational burden [TMB]) will be randomized to receive pembrolizumab in combination with …

St James Hospital ( Site 2200)
 (3.9 away) Contact site
  • 352 views
  • 21 Jun, 2021
  • +92 other locations
The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

The Safety and Efficacy of Psilocybin in Participants with Treatment Resistant Depression

psilocybin
Tallaght University Hospital
 (1.9 away) Contact site
  • 3258 views
  • 04 Apr, 2021
  • +23 other locations
Paricalcitol Trial

The trial is designed to establish whether adding a vitamin D analogue, Paricalcitol, to standard chemotherapy treatment, Gemcitabine and Nab-paclitaxel, can improve the outcomes for patients with advanced pancreatic cancer.

Beaumont Hospital
 (1.9 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +5 other locations
ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation

The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). …

sacubitril
valsartan
hypertension
diabetes
heart failure
The STOP-HF Service, St Michael's Hosptial
 (4.5 away) Contact site
  • 0 views
  • 08 Nov, 2020
  • 1 location
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

The trial is open to all patients with a diagnosis of acute promyelocytic leukemia (APL) who are PCR-positive for the PML-RAR transcript and less than 18 years of age.

Our Lady's Children's Hospital Crumlin
 (1.9 away) Contact site
  • 0 views
  • 21 Mar, 2021
  • +28 other locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

tyrosine
lung carcinoma
lung cancer
cancer
measurable disease
St. Vincent's University Hospital
 (1.9 away) Contact site
  • 0 views
  • 03 Jun, 2021
  • +194 other locations
Derazantinib in Subjects With FGFR2 Gene Fusion- Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma

This pivotal, open-label, single-arm study will evaluate the anti-cancer activity of derazantinib by Objective Response Rate (ORR) by central radiology review as per RECIST v1.1 in subjects with inoperable or advanced intrahepatic cholangiocarcinoma (iCCA) whose tumors harbor FGFR2 gene fusions (by FISH performed by the central laboratory) or FGFR2 gene …

anticoagulants
progestin
icca
platelet count
neutrophil count
St. James's Hospital
 (2.9 away) Contact site
  • 190 views
  • 20 Jun, 2021
  • +50 other locations
Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations

This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors.

St. Vincent's University Hospital
 (1.1 away) Contact site
  • 83 views
  • 27 May, 2021
  • +71 other locations