Dublin 4, Ireland Clinical Trials

A listing of Dublin 4, Ireland clinical trials actively recruiting patients volunteers.

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Found 187 clinical trials
Abatacept for the Treatment of Relapsing Non-Severe Granulomatosis With Polyangiitis (Wegener's)

Multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of abatacept to achieve sustained glucocorticoid-free remission in patients with relapsing non-severe granulomatosis with polyangiitis (Wegener's) (GPA) . Participants will be randomized 1:1 to receive either abatacept 125 mg or placebo administered by subcutaneous injection once a week. Participants will continue …

churg-strauss syndrome
urinary sediment
nasal discharge
eosinophilic granulomatosis
norplant
St. Vincent's University Hospital
 (1.9 away) Contact site
  • 197 views
  • 28 Apr, 2021
  • +25 other locations
Study of the Efficacy and Safety of Immune Globulin Intravenous (Human) Flebogamma 5% DIF in Patients With Post-polio Syndrome

This is a multicenter, prospective, randomized, placebo-controlled, double-blind, parallel group clinical trial with adaptive dose selection in subjects with post polio syndrome (PPS). The main purpose of this study is to select a dose of Flebogamma 5% DIF and confirm the efficacy of the selected Flebogamma 5% DIF dose by …

Beaumont Hospital
 (3.5 away) Contact site
  • 167 views
  • 29 Jan, 2021
  • +55 other locations
Phase III Radium 223 mCRPC-PEACE III

The objective of this randomized phase III open label trial is to assess if upfront combination of enzalutamide and Ra223 improves radiological progression-free survival compared to enzalutamide single agent in asymptomatic or mildly symptomatic castration resistant prostate cancer patients metastatic to bone.

adenocarcinoma of prostate
prednisone
neutrophil count
bilateral orchidectomy
docetaxel
St. Vincent's University Hospital
 (1.9 away) Contact site
  • 503 views
  • 25 Jan, 2021
  • +57 other locations
Study of Efficacy of CDZ173 in Patients With APDS/PASLI

This study is designed to explore CDZ173, a selective PI3K inhibitor, in patients with genetically activated PI3K, i.e., patients with APDS/PASLI. The study consists of two parts. Part I is the open label part designed to establish the safety and pharmacokinetics of CDZ173 in the target population, as well as …

Novartis Investigative Site
 (1.9 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +11 other locations
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU001

The purpose of this study is to assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive impairment and improves disease-related biomarkers.

mild cognitive impairment
positron emission tomography
alzheimer's disease
cognitive impairment
dementia
The National Hospital for Neurology and Neurosurgery
 (284.7 away) Contact site
  • 980 views
  • 25 Jan, 2021
  • +56 other locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

cancer
lung cancer
NTRK
breast cancer
measurable disease
St. Vincent's University Hospital
 (1.9 away) Contact site
  • 0 views
  • 03 Jun, 2021
  • +194 other locations
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children

The study is being done to test the safety of a cancer drug called larotrectinib in children. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib blocks the actions of these NTRK genes in cancer cells and can therefore be used to treat cancer. …

primary cancer
breast cancer
metastatic solid tumor
metastasis
solid tumor
Our Lady's Hospital For Sick Children
 (3.7 away) Contact site
  • 0 views
  • 20 Jun, 2021
  • +71 other locations
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

The main purpose of this study is : To establish which number of doses of gemtuzumab ozogamicin (up to a maximum of 3 doses) is tolerated and can be safety delivered in combination with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal …

induction chemotherapy
busulfan
cytarabine
gilbert's syndrome
neoadjuvant therapy
Our Lady's Hospital for Sick Children
 (1.9 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +58 other locations
A Study to Evaluate the Safety Pharmacokinetics and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation

The purpose of this study is to evaluate the safety of ivacaftor treatment, and PK of ivacaftor and metabolites in subjects with cystic fibrosis (CF) who are <24 months of age at treatment initiation and have an ivacaftor-responsive CF transmembrane conductance regulator (CFTR) gene mutation.

fibrosis
ivacaftor
sweat test
 (1.9 away) Contact site
  • 0 views
  • 28 Jan, 2021
  • +22 other locations
A Study to Test the Safety of the Investigational Drug Selitrectinib in Children and Adults That May Treat Cancer

This research study is done to test the safety of the new drug selitrectinib in children and adults with cancer having a change in a particular gene (NTRK1, NTRK2 or NTRK3). The drug may treat cancer by interfering with the effect of the NTRK genes on cancer growth. The study …

fibrosarcoma
kidney function test
solid tumor
kidney function tests
cancer
Tallaght Hospital
 (5.5 away) Contact site
  • 1310 views
  • 20 Jun, 2021
  • +78 other locations