Dublin 4, Ireland Clinical Trials

A listing of Dublin 4, Ireland clinical trials actively recruiting patients volunteers.

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Found 185 clinical trials
An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease

This is a Phase 3, open-label, multicenter extension study to evaluate safety and efficacy of ozanimod in subjects with moderately to severely active Crohn's Disease.

crohn's disease
remission
Beaumont Hospital
 (4.1 away) Contact site
  • 1032 views
  • 22 Feb, 2021
  • +807 other locations
A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease

This is a Phase 3, randomized, double-blind, placebo-controlled study to demonstrate the effect of oral ozanimod as maintenance therapy in subjects with moderately to severely active Crohn's Disease.

crohn's disease
remission
abdominal pain
Beaumont Hospital
 (4.1 away) Contact site
  • 858 views
  • 23 Feb, 2021
  • +780 other locations
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II IIIA and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

This trial will evaluate the safety and efficacy of pembrolizumab (MK-3475) in combination with platinum doublet neoadjuvant chemotherapy (NAC) before surgery [neoadjuvant phase], followed by pembrolizumab alone after surgery [adjuvant phase] in participants with resectable stage II, IIIA, and resectable IIIB (T3-4N2) non-small cell lung cancer (NSCLC). The primary hypotheses …

solid tumour
gemcitabine
pemetrexed
mk-3475
platinum doublet
St James Hospital ( Site 0451)
 (1.9 away) Contact site
  • 551 views
  • 09 Jun, 2021
  • +237 other locations
PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer

This is prospective, multicenter, randomised phase III trial among women with endometrial cancer with high-intermediate risk features to investigate the role of an integrated clinicopathological and molecular risk profile to determine if participants should receive no adjuvant therapy, vaginal brachytherapy or external beam radiotherapy based on a favourable, intermediate or …

CancerTrials Ireland - St James Hospital (SLRON SJH)
 (1.9 away) Contact site
  • 72 views
  • 23 Jan, 2021
  • +25 other locations
A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)

The purpose of this study is to evaluate the safety and tolerability of long-term treatment with ontamalimab in participants with moderate to severe Ulcerative Colitis (UC) or Crohn's disease (CD).

endoscopy
ulcerative colitis
hematochezia
sigmoidoscopy or colonoscopy
crohn's disease
Royal Shrewsbury Hospital
 (148.4 away) Contact site
  • 1349 views
  • 09 Jun, 2021
  • +818 other locations
Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease

The modified-Exclusive Enteral Nutrition (mEEN) is an open label randomized controlled trial in mild to severe Crohn's Disease patients. The purpose of this study is to determine whether induction of remission and maintenance of remission can be achieved with a new dietary strategy that involves only 2 weeks of Exclusive …

enteral nutrition
crohn's disease
induction of remission
remission
Dr. S amus Hussey
 (1.9 away) Contact site
  • 496 views
  • 26 Jan, 2021
  • +9 other locations
A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours. Anyone diagnosed with a minor stroke faces the possibility of long-term disability and even death, regardless of treatment. Stroke symptoms such as weakness, difficulty …

transient ischemic attack
ischemia
angiography
deficit
weakness
Beaumont Hospital
 (1.9 away) Contact site
  • 96 views
  • 26 Jan, 2021
  • +58 other locations
Randomized Embedded Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of …

Beaumont Hospital
 (1.9 away) Contact site
  • 2104 views
  • 26 Jan, 2021
  • +107 other locations
Induction Study #1 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease

This is a Phase 3, randomized, double-blind, placebo-controlled study to explore the effect of oral ozanimod as an induction treatment for subjects with moderately to severely active Crohn's Disease.

endoscopy
ileal disease
corticosteroids
immunomodulators
crohn's disease
Beaumont Hospital
 (4.0 away) Contact site
  • 865 views
  • 09 Mar, 2021
  • +420 other locations
Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)

The study will compare the efficacy and safety of pembrolizumab plus trastuzumab in combination with standard of care (SOC) chemotherapy versus trastuzumab in combination with SOC chemotherapy in participants with HER2-positive gastric cancer. The primary hypotheses of the study are that pembrolizumab plus trastuzumab in combination with chemotherapy is superior …

tegafur
solid tumour
gastric cancer
human epidermal growth factor
mk-3475
Saint James's Hospital ( Site 1505)
 (2.8 away) Contact site
  • 303 views
  • 12 Jun, 2021
  • +206 other locations