Dublin 24, Ireland Clinical Trials

A listing of Dublin 24, Ireland clinical trials actively recruiting patients volunteers.

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Found 17 clinical trials
The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

The Safety and Efficacy of Psilocybin in Participants with Treatment Resistant Depression

Tallaght University Hospital
 (6.4 away) Contact site
  • 04 Apr, 2021
  • +23 other locations
Surgery in Treating Patients With Neuroblastoma

RATIONALE: Surgery may be an effective treatment for neuroblastoma. PURPOSE: This phase II trial is studying how well surgery works in treating patients with neuroblastoma.

Our Lady's Hospital for Sick Children Crumlin
 (4.6 away) Contact site
  • 07 Nov, 2020
  • +18 other locations
A Study of Biomarker-Directed Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)

This study will investigate the utility of biomarker-based triage for study participants with advanced non-small cell lung cancer (NSCLC) without prior systemic therapy. Study participants within groups defined by a biomarker-based classifier (gene expression profile [GEP] and tumor mutational burden [TMB]) will be randomized to receive pembrolizumab in combination with …

St James Hospital ( Site 2200)
 (4.8 away) Contact site
  • 16 Jun, 2021
  • +92 other locations
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

This study will evaluate the efficacy and safety of olaparib (MK-7339) monotherapy in participants with multiple types of advanced cancer (unresectable and/or metastatic) that: 1) have progressed or been intolerant to standard of care therapy; and 2) are positive for homologous recombination repair mutation (HRRm) or homologous recombination deficiency (HRD).

Tallaght Hospital ( Site 1652)
 (6.4 away) Contact site
  • 20 Jun, 2021
  • +146 other locations
ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation

The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). …

natriuretic peptide
heart failure
The STOP-HF Service, St Michael's Hosptial
 (9.8 away) Contact site
  • 08 Nov, 2020
  • 1 location
Paricalcitol Trial

The trial is designed to establish whether adding a vitamin D analogue, Paricalcitol, to standard chemotherapy treatment, Gemcitabine and Nab-paclitaxel, can improve the outcomes for patients with advanced pancreatic cancer.

Tallaght University Hospital
 (4.7 away) Contact site
  • 26 Jan, 2021
  • +5 other locations
Safety Tolerability and Pharmacodynamic Effect of ARO-AAT

The purpose of AROAAT2001 (SEQUOIA) is to evaluate the safety, efficacy and tolerability of multiple doses of the investigational product, ARO-AAT, administered subcutaneously to participants with alpha-1 antitrypsin deficiency (AATD).

alpha1-proteinase inhibitor (human)
RCSI Education & Research Centre, Beaumont Hospital
 (8.4 away) Contact site
  • 15 May, 2021
  • +25 other locations
A Study to Assess the Antitumor Activity and Safety of IMAB362 in Combination With Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects With Claudin 18.2 (CLDN18.2) Positive Metastatic Pancreatic Adenocarcinoma

The purpose of this study is to confirm the recommended phase 2 dose (RP2D) of zolbetuximab in combination with Nab-P + GEM, determine overall survival and assess the safety and tolerability of the combination treatment. This study will also evaluate other anti-tumor effects, tumor markers and pharmacokinetics (PK) of zolbetuximab, …

metastatic pancreatic adenocarcinoma
liver metastasis
adjuvant therapy
pancreatic adenocarcinoma
Site IR35301
 (6.6 away) Contact site
  • 13 May, 2021
  • +111 other locations
Efficacy and Safety of T-817MA in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD

Primary objective is to evaluate the neuroprotective effect of T-817MA on Tau protein phosphorylated at threonine 181 (p-tau 181) in cerebrospinal fluid (CSF) compared with placebo in patients with a diagnosis of MCI due to AD or mild AD. Secondary objectives are: To evaluate in patients on T-817MA and placebo: …

alzheimer's disease
tau protein
Tallaght University Hospital.
 (6.4 away) Contact site
  • 27 Jan, 2021
  • +61 other locations
Derazantinib in Subjects With FGFR2 Gene Fusion- Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma

This pivotal, open-label, single-arm study will evaluate the anti-cancer activity of derazantinib by Objective Response Rate (ORR) by central radiology review as per RECIST v1.1 in subjects with inoperable or advanced intrahepatic cholangiocarcinoma (iCCA) whose tumors harbor FGFR2 gene fusions (by FISH performed by the central laboratory) or FGFR2 gene …

liver metastases
tubal ligation
measurable disease
St. James's Hospital
 (4.8 away) Contact site
  • 04 Feb, 2021
  • +50 other locations