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Medicine & Geriatrics, Hong Kong Clinical Trials

A listing of Medicine & Geriatrics, Hong Kong clinical trials actively recruiting patients volunteers.

RESULTS

Found (2419) clinical trials

An Efficacy Study Comparing Ponatinib Versus Imatinib Administered in Combination With Reduced-Intensity Chemotherapy in Participants With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

The drug being tested in this study is called ponatinib. Ponatinib is being tested to treat people who have newly diagnosed Ph+ ALL. This study will look at the efficacy of ponatinib in participants in addition to standard care. The study will enroll approximately 230-320 patients. Patients will be randomized ...

Phase

0.25 miles

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Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

Pregnant women experience unique physiological changes that may result in clinically significant alterations in drug PKs. Unfortunately, there have been few clinical trials to study the PKs of ARV, TB, and hormonal contraceptive drugs in pregnant women. The development of appropriate dosing regimens for the HIV-infected pregnant woman is critical ...

Phase

0.5 miles

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A Phase II Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma

Adult patients with histologically or cytologically confirmed advanced or metastatic cholangiocarcinoma with FGFR genetic alterations who have evidence of radiologic progression following a cisplatin-and gemcitabine-containing regimen for advanced disease or a gemcitabine-containing regimen for those who are considered intolerant to cisplatin will be enrolled. Approximately 55 adult patients over age ...

Phase

0.5 miles

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Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors

OBJECTIVES: - Compare progression-free survival rates of patients with poor prognosis stage II or III non-seminomatous germ cell tumors with an unfavorable decrease of tumor markers after treatment with 1 course of bleomycin, etoposide, and cisplatin followed by subsequent treatment with 3 additional courses of bleomycin, etoposide, and cisplatin OR ...

Phase

0.5 miles

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A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Primary Objectives: To estimate the progression free survival distribution of WNT-medulloblastoma patients treated on Stratum W1 with reduced-dose craniospinal irradiation and reduced-dose cyclophosphamide. To estimate progression-free survival distribution of Non-WNT Non-SHH medulloblastoma patients treated on Stratum N1 with reduced dose cyclophosphamide. To evaluate the effect of an aerobic training intervention, ...

Phase

0.5 miles

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Cyclophosphamide Alemtuzumab Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Severe Aplastic Anemia

OBJECTIVES: - To assess the safety of the conditioning regimen using cyclophosphamide, total-body irradiation, and alemtuzumab in patients with severe aplastic anemia. - To assess engraftment and the risk of graft failure in this patient population. - To assess the risk of acute and chronic graft-vs-host disease. - To estimate ...

Phase

0.5 miles

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Etoposide and Cisplatin in Treating Young Patients With Previously Untreated High-Risk Neuroblastoma Undergoing High-Dose Chemotherapy Stem Cell Transplant and Isotretinoin

OBJECTIVES: Primary - Estimate the response rate associated with two courses of cisplatin and protracted oral etoposide when administered as up-front window therapy to pediatric patients with previously untreated high-risk neuroblastoma undergoing high-dose chemotherapy and stem cell rescue followed by maintenance therapy comprising isotretinoin. - Describe the toxicities associated with ...

Phase

0.5 miles

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Anti-CD45 Monoclonal Antibody Cytarabine Cyclophosphamide and Total-Body Irradiation With or Without Alemtuzumab in Treating Patients Undergoing a Donor Stem Cell Transplant For Advanced Leukemia or Other Hematologic Cancer

OBJECTIVES: Primary - To evaluate the toxicity and the anti-tumor activity of anti-CD45 monoclonal antibody in patients with relapsed or resistant leukemia or other hematologic malignancy undergoing allogeneic stem cell transplantation. Secondary - To describe the effects of anti-CD45 on normal hematopoiesis and on complement levels. - To describe the ...

Phase

0.5 miles

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T-Lymphocytes in Treating Patients With Relapsed or Refractory Low-Grade B-Cell Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia

OBJECTIVES: Primary - To evaluate the safety of autologous T-lymphocytes genetically modified to express artificial T-cell receptors (CAR) targeting the CD19 molecule (CD19CAR) in patients with refractory or relapsed low-grade B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia. Secondary - To measure the survival and function of CD19CAR T-cells in vivo. ...

Phase

0.5 miles

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T Lymphocytes in Treating Patients Undergoing a Donor Bone Marrow Transplant

OBJECTIVES: - To generate Epstein-Barr virus (EBV)-specific cytotoxic T-cell lines from bone marrow transplantation (BMT) donors. - To determine the safety of one intravenous injection of BMT donor-derived EBV-specific cytotoxic T lymphocytes (CTLs) in BMT recipients at high risk. - To compare the antiviral and immunological efficacy of a single ...

Phase

0.5 miles

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